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Bioorg Med Chem Lett ; 16(21): 5493-7, 2006 Nov 01.
Article in English | MEDLINE | ID: mdl-16934977

ABSTRACT

Binding affinities for a range of epibatidine isomers and analogues at the alpha4beta2 and alpha3beta4 nAChR subtypes are reported; compounds having similar N-N distances to epibatidine show similar, high potencies.


Subject(s)
Bridged Bicyclo Compounds, Heterocyclic/chemistry , Bridged Bicyclo Compounds, Heterocyclic/pharmacology , Nicotinic Agonists/chemistry , Nicotinic Agonists/pharmacology , Pyridines/chemistry , Pyridines/pharmacology , Cell Line , Humans , Isomerism , Structure-Activity Relationship
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