ABSTRACT
Hygienic classifications of pesticides used in the Russian Federation are presented. The classifications cover both technical products and preparative forms of pesticides. Four classes of hazards are distinguished: extremely hazardous, hazardous, moderately hazardous, and slightly hazardous. These four classes are used for classifying general toxicity (peroral, skin, inhalation), cumulative, allergic, teratogenic, embryotoxic, reproductive, mutagenic, carcinogenic effects, and the stability in soil. The class of the hazard is determined on the basis of toxicohygienic evaluation of a pesticide, taking into account a limiting criterion of the hazard.
Subject(s)
Allergens/toxicity , Carcinogens/toxicity , Mutagens/toxicity , Pesticides/classification , Teratogens/toxicity , Pesticides/toxicity , RussiaABSTRACT
The toxic effect of deoxynivalenol was studied in experiments on 8 test and 3 control Macaca rhesus monkeys. It has been found that differences in the hemostasis parameters depend on the frequency of deoxynivalenol administration. Normalization of the blood coagulation process is recorded after 1.5-2 months. Early diagnosis of intoxication with mycotoxins, deoxynivalenol in particular, is of great prognostic significance and may help prevent the development of irreversible changes in the body.
Subject(s)
Hemostasis/drug effects , Trichothecenes/toxicity , Animals , Macaca mulattaSubject(s)
Air Pollutants, Occupational/toxicity , Chemical Industry/standards , Chromosome Aberrations/genetics , Lymphocytes/drug effects , Morpholines/toxicity , Mutagenesis/drug effects , Mutagens/toxicity , Occupational Medicine/standards , Dose-Response Relationship, Drug , Humans , Lymphocytes/ultrastructure , Maximum Allowable Concentration , Morpholines/administration & dosage , Morpholines/standards , Mutagenesis/genetics , Mutagens/administration & dosage , Mutagens/standards , RussiaABSTRACT
Mutagenic character of formaldehyde in vivo was estimated by determining the level of chromosomal aberrations, sister chromatid exchanges and unscheduled DNA synthesis in human lymphocytes. It was found that in case of occupational exposure to formaldehyde the unscheduled DNA synthesis after thiophosphamide treatment in vitro was inhibited and spontaneous level of chromosomal aberrations increased. A negative correlation observed between the unscheduled DNA synthesis and sister chromatid exchanges indirectly confirmed a connection of these exchanges with the DNA repair. The comparison of the results obtained from evaluation of chromosomal aberrations, sister chromatid exchanges and unscheduled DNA synthesis permits suggesting that these methods estimate different sides of the mutagen interaction with a cell and should be considered as mutually complementary methods but not as interchangeable ones.
Subject(s)
Air Pollutants, Occupational/adverse effects , Chromosome Aberrations/drug effects , DNA Repair/drug effects , Formaldehyde/adverse effects , Mutagens , Sister Chromatid Exchange/drug effects , Humans , Lymphocytes/ultrastructure , Mutagenicity TestsSubject(s)
Health Status , Health , Mutagens/adverse effects , Sulfuric Acid Esters/adverse effects , Sulfuric Acids/adverse effects , B-Lymphocytes/drug effects , B-Lymphocytes/immunology , Cells, Cultured , Chromosome Aberrations , Dose-Response Relationship, Drug , Environmental Exposure , Humans , Immunity, Cellular/drug effects , Liver Function Tests , T-Lymphocytes/drug effects , T-Lymphocytes/immunologySubject(s)
Hemorrhagic Disorders/etiology , Lymphoma/complications , Animals , Female , Male , PapioABSTRACT
1. The protein and glycoprotein composition of the blood platelets of six primate species have been compared by high resolution two-dimensional polyacrylamide gel electrophoresis. 2. Only minor differences have been observed in the protein patterns of all six species. 3. The glycopeptide patterns of the monkey platelets five species) were rather uniform, but clearly different from the human pattern.
