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Antibiot Khimioter ; 35(8): 17-20, 1990 Aug.
Article in Russian | MEDLINE | ID: mdl-2264746

ABSTRACT

Dioxidine++-induced changes were shown to occur in the protein composition of the cells of Staphylococcus aureus. The most significant damages were observed in the composition of exoproteins. Dioxidine++ had a specific inhibitory effect on intracellular nuclease, which was accompanied by a decrease in virulence and disorders in the toxin formation.


Subject(s)
Anti-Bacterial Agents/pharmacology , Bacterial Proteins/metabolism , Deoxyribonucleases/metabolism , Membrane Proteins/metabolism , Peptide Hydrolases/metabolism , Quinoxalines/pharmacology , Staphylococcus aureus/drug effects , Cell Membrane/drug effects , Cell Membrane/metabolism , Deoxyribonucleases/antagonists & inhibitors , In Vitro Techniques , Staphylococcus aureus/metabolism , Staphylococcus aureus/ultrastructure
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