ABSTRACT
A baboon was exchange-transfused with sickle cell anemia patients' blood. The animal died suddenly, and postmortem examination showed widespread red cell sequestration, particularly in the spleen and liver. The clinical and pathological findings were similar to those in children with sickle cell anemia who die of acute splenic sequestration syndrome. A control animal, exchange-transfused with normal human blood, tolerated the procedure without difficulties for a period of 4 days, when a delayed transfusion reaction occurred. Thus the baboon can be used as a model for the abnormal circulatory behavior of sickle cells and for the sickle cell sequestration syndrome.
Subject(s)
Anemia, Sickle Cell/blood , Exchange Transfusion, Whole Blood , Papio/physiology , Sickle Cell Trait/blood , Animals , Erythrocytes/physiology , Humans , Sickle Cell Trait/pathologyABSTRACT
A two-day-old black male term infant developed meningitis due to Hemophilus para-influenzae, a rare cause of neonatal meningitis. The organism was sensitive to ampicillin and chloramphenicol. Of interest was that the mother had the same organism in her cervix. The need for prompt investigation and institution of appropriate antibiotic therapy is emphasized.
Subject(s)
Meningitis, Haemophilus/diagnosis , Adult , Bacteriological Techniques , Cervix Uteri/microbiology , Female , Humans , Infant, Newborn , Male , Meningitis, Haemophilus/transmission , PregnancyABSTRACT
The value of ultrasound examination in a case of neonatal hydrometrocolpos is presented. Ultrasound proved the pelvic origin and the cystic nature of the mass, determinations essential to a correct diagnosis.
Subject(s)
Genital Diseases, Female/congenital , Ultrasonography , Vagina/abnormalities , Cysts/diagnosis , Female , Humans , Infant, NewbornABSTRACT
Traumatic femoral epiphyseal periostitis is a rare complication of breech delivery by cesarean section. The clinical course and management of a case of distal femoral periostitis recently encountered by the authors is discussed.
Subject(s)
Birth Injuries/complications , Breech Presentation , Femur/injuries , Labor Presentation , Periostitis/etiology , Adolescent , Cesarean Section , Epiphyses/injuries , Female , Humans , Infant, Newborn , PregnancyABSTRACT
Fifty healthy newborn infants were studied in an attempt to test the accuracy of several recently reported shortened methods of gestational age determination. The Finnstrom method with seven external characteristics was more accurate than those that contained only five or less criteria. In the statistical analysis it also yielded results that were very similar to those obtained using the original Dubowitz technique which has 21 criteria.
Subject(s)
Gestational Age , Humans , Infant, Newborn , MethodsABSTRACT
This paper discusses the management of multisystemic sequelae of perinatal asphyxia. Appropriate intrapartum and subsequent adequate neonatal monitoring are an absolute necessity for the early detection of systemic dysfunctions. Prophylactic and therapeutic measures applicable to the various organ malfunctions are described.
Subject(s)
Asphyxia Neonatorum/complications , Asphyxia/complications , Fetal Diseases/complications , Asphyxia Neonatorum/therapy , Brain Diseases/etiology , Cardiovascular Diseases/etiology , Female , Humans , Infant, Newborn , Kidney Diseases/etiology , Lung Diseases/etiology , Metabolic Diseases/etiology , Monitoring, Physiologic , PregnancyABSTRACT
This paper describes the clinical and pathologic sequelae of perinatal asphyxia manifested by 17 neonates treated at Howard University Hospital over an 18-month period. Multiple systemic complications, occurring in 76.5 percent of the patients, were the rule rather than the exception. All vital organs were involved, singly or in combination. Understanding the pathogenesis and extent of these complications is of utmost importance not only to those rendering health care to acutely ill newborns, but also to those responsible for prenatal and maternal intrapartum care.
