ABSTRACT
Transverse myelitis can be a complication of SARS-CoV-2 infection. We report the case of a transverse myelitis related to SARS-CoV-2 infection. Beyond the disease itself, neurological involvement affects functionality. In this situation, physical and rehabilitation medicine plays a crucial role in managing patient rehabilitation.
ABSTRACT
Background: Osteochondroses are a set of conditions concerning the ossification of the developing bone. Higher intensity in sports activities can increase its occurrence in children. There is no consensus on its etiology, with multiple factors being involved. Van Neck-Odelberg disease is a rare osteochondrosis located in ischiopubic synchondrosis. Treatment is mainly conservative, with activity suspension. Addressing and correcting the predisposing factors is crucial to these injuries. Case report: We present a case of a 6-year-old futsal player who experienced mechanical inguinal moderate pain during sports practice. After performing physical examination, laboratory tests, and radiographic evaluation, the patient was diagnosed with Van Neck-Odelberg disease. Sports activities were suspended while a conservative treatment was performed, with subsequent follow-up over 3.5 years. No symptom recurrence was reported. Conclusion: Increased intensity of sports activities is associated with overuse injuries in children, especially before completing the ossification process. Preventive measures must remain the primary concern in children's sports practice.
ABSTRACT
The ability to rapidly assemble and prototype cellular circuits is vital for biological research and its applications in biotechnology and medicine. The Mammalian ToolKit (MTK) is a Golden Gate-based cloning toolkit for fast, reproducible and versatile assembly of large DNA vectors and their implementation in mammalian models. The MTK consists of a curated library of characterized, modular parts that can be assembled into transcriptional units and further weaved into complex circuits. These circuits are easily repurposed and introduced in mammalian cells by different methods.
ABSTRACT
How fast? How strong? How many? So what? Why do numbers matter in biology? Chromatin binding proteins are forever in motion, exchanging rapidly between bound and free pools. How do regulatory systems whose components are in constant flux ensure stability and flexibility? This review explores the application of quantitative and mathematical approaches to mechanisms of epigenetic regulation. We discuss methods for measuring kinetic parameters and protein quantities in living cells, and explore the insights that have been gained by quantifying and modelling dynamics of chromatin binding proteins.
