Characterization of radon levels in soil and groundwater in the North Maladeta Fault area (Central Pyrenees) and their effects on indoor radon concentration in a thermal spa.

Radon levels in the soil and groundwater in the North Maladeta Fault area (located in the Aran Valley sector, Central Pyrenees) are analysed from both geological and radiation protection perspectives. This area is characterized by the presence of two important normal faults: the North Maladeta fault (NMF) and the Tredós Fault (TF). Two primary aspects make this study interesting: (i) the NMF shows geomorphic evidence of neotectonic activity and (ii) the presence of a thermal spa, Banhs de Tredós, which exploits one of the several natural springs of the area and needs to be evaluated for radiation dosing from radon according to the European regulation on basic safety standards for protection against ionizing radiation. The average soil radon and thoron concentrations along a profile perpendicular to the two normal faults - 22 ±â€¯3 kBq·m-3 and 34 ±â€¯3 kBq·m-3, respectively - are not high and can be compared to the radionuclide content of the granitic rocks of the area, 25 ±â€¯4 Bq·kg-1 for 226Ra and 38 ±â€¯2 Bq·kg-1 for 224Ra. However, the hypothesis that the normal faults are still active is supported by the presence of anomalies in both the soil radon and thoron levels that are unlikely to be of local origin together with the presence of similar anomalies in CO2 fluxes and the fact that the highest groundwater radon values are located close to the normal faults. Additionally, groundwater 222Rn data have complemented the hydrochemistry data, enabling researchers to better distinguish between water pathways in the granitic and non-granitic aquifers. Indoor radon levels in the spa vary within a wide range, [7-1664] Bq·m-3 because the groundwater used in the treatment rooms is the primary source of radon in the air. Tap water radon levels inside the spa present an average value of 50 ±â€¯8 kBq·m-3, which does not exceed the level stipulated by the Spanish Nuclear Safety Council (CSN) of 100 kBq·m-3 for water used for human consumption. This finding implies that even relatively low radon concentration values in water can constitute a relevant indoor radon source when the transfer from water to indoor air is efficient. The estimated effective dose range of values for a spa worker due to radon inhalation is [1-9] mSv·y-1. The use of annual averaged radon concentration values may significantly underestimate the dose in these situations; therefore, a detailed dynamic study must be performed by considering the time that the workers spend in the spa.

Soil radon dynamics in the Amer fault zone: An example of very high seasonal variations.

Soil radon levels of the Amer fault zone have been measured for a 4 year-period with the aim of checking seasonal fluctuations obtained in previous studies and to understand radon origin and dynamics. In this manuscript additional results are presented: updated continuous and integrated soil radon measurements, radionuclide content of soil materials and a detailed analysis of an urban profile by means of the electrical resistivity imaging technique and punctual soil radon, thoron and CO2 measurements. Integrated and continuous measurements present a wide range of values, [0.2-151.6] kBq m(-3) for radon, [4.5-39.6] kBq m(-3) for thoron and [4.0-71.2] g m(-2) day(-1) for CO2. The highest soil radon levels in the vicinity of the Amer fault (>40 kBq m(-3)) are found close to the fractured areas and present very important fluctuations repeated every year, with values in summer much higher than in winter, confirming previous studies. The highest radon values, up to 150 kBq m(-3), do not have a local origin because the mean value of radium concentration in this soil (19 ± 5 Bq kg(-1)) could not explain these values. Then soil radon migration through the fractures, influenced by atmospheric parameters, is assumed to account for such a high seasonal fluctuation. As main conclusion, in fractured areas, seasonal variations of soil radon concentration can be very important even in places where average soil radon concentration and radium content are not especially high. In these cases the migration capability of the soil is given not by intrinsic permeability but by the fracture structure. Potential risk estimation based on soil radon concentration and intrinsic permeability must be complemented with geological information in fractured systems.

Radon levels in groundwaters and natural radioactivity in soils of the volcanic region of La Garrotxa, Spain.

Groundwater radon level and soil radionuclide concentration have been measured in the volcanic region of La Garrotxa (Catalonia, Spain) to further research on the origin and dynamics of high radon levels over volcanic materials found in this region. Water samples from different aquifers have been collected from wells and springs and the water radon levels obtained have been lower than 30 Bq l(-1). Soil samples have been collected from different geological formations (volcanic and non-volcanic), being Quaternary sedimentary deposits those that have presented the highest mean values of (40)K, (226)Ra and (232)Th concentrations (448 ± 70 Bq kg(-1), 35 ± 5 Bq kg(-1) and 38 ± 5 Bq kg(-1), respectively). Additionally, indoor/outdoor terrestrial radiation absorbed dose rate in air have been measured to better characterize the region from the radiological point of view. Terrestrial radiation absorbed dose rates measurement points have been chosen on the basis of geological and demographical considerations and the results obtained, from 27 to 91 nGy h(-1), show a clear relation with geological formation materials. The highest terrestrial gamma absorbed dose rate is observed over Quaternary sedimentary deposits as well. All these results help to better understand previous surveys related with indoor and outdoor radon levels and to reinforce the hypotheses of a radon transport through the fissure network.

Adverse prognostic impact of CD36 and CD2 expression in adult de novo acute myeloid leukemia patients.

BACKGROUND AND OBJECTIVES: A consecutive series of acute myeloid leukemias (AML) patients was analyzed in conditions which reduce the inter-assay variations (the same flow cytometer, the same observers and the same panel of monoclonal antibodies) in order to investigate the prognostic information provided by flow cytometry. DESIGN AND METHODS: Two hundred and sixty-six bone marrow (BM) samples from 326 patients enrolled in the LMA-99 protocol from the CETLAM group were studied by multiparametric flow cytometry. Immunophenotyping studies were performed on erythrocyte-lysed BM samples. Antigen expression of leukemic cells was analyzed using triple stainings with fluorochrome-conjugated combinations of monoclonal antibodies. RESULTS: CD2 was positive in 21 cases (8%); an associated inv(16) was detected in eight CD2+ cases (38%). Two-year overall survival (OS) rate for CD2+/inv(16)+ patients was 75%, whereas it was 0% for CD2+/inv(16)- patients and 47% for CD2- patients (p=0.0001). CD36 was expressed in 37% of patients (n=98). Two-year leukemia-free survival (LFS) rate was 34% for CD36+ patients and 55% for CD36- patients (p=0.001). In the multivariate analysis, CD2+ (RR=8.4; p=0.0001) and adverse karyotype (RR=10.2; p=0.0001) were associated with a lower CR rate, CD36+ (RR=1.5; p=0.03), CD2+ (RR=2; p=0.04) and adverse karyotype (RR=4; p=0.0001) were associated with a lower OS and CD36+ (RR=2; p=0.002) and adverse karyotype (RR=3.5; p=0.005) predicted a lower LFS. CONCLUSIONS: CD2+ patients had a very poor OS when CD2/inv(16)+ cases were excluded. CD36 and CD2 expression at diagnosis can provide prognostically important information in adult de novo AML.

The RAGENA dynamic model of radon generation, entry and accumulation indoors.

The complexity generated by the existence of a great number of parameters and processes affecting the generation of radon in the source, its transport in the source medium, its entry into a dwelling and its accumulation in the different rooms of a dwelling has led to the development of partial models and experimental studies that are focused on a given aspect. However, in order to model radon levels and dynamics in real houses, it is necessary to take into account all the parameters and processes affecting radon levels. This is the objective of the dynamic RAGENA model of radon generation, entry and accumulation indoors. The model has been adapted to a Mediterranean climate house under dynamic conditions, and the indoor radon and soil radon dynamics have been compared to experimental results. It has been found (i) that the model gives a soil radon dynamics similar to that obtained experimentally, (ii) a remarkable model-experiment agreement indoors and (iii) that the indoor radon dynamics is given by a permanent radon entry from building materials and a dynamic removal through ventilation, which is driven by indoor-outdoor temperature differences and wind speed.

Effect of soil parameters on radon entry into a building by means of the transrad numerical model.

High indoor radon concentration means an increased risk of developing lung cancer. When high radon levels are present in a dwelling, the major source is normally the soil. Therefore, it is useful to know the radon concentration field in the soil underneath a building. A steady-state two-dimensional radon transport model has been used to calculate the effect of a reference building on the soil radon concentration, and the influence of soil parameters on radon entry through a single crack in the basement. Both advective and diffusive flows are considered. Away from the building, the well-known undisturbed soil radon concentration profile has been obtained, while under the house the radon level is increased. A variability analysis around the reference site has shown that the most relevant soil parameters on the radon flux at the top of the crack are, in this case, effective diffusion coefficient, soil gas-permeability and deep soil radon concentration.