Thiol-reactive (co)polymer scaffolds comprising organic arsenical acrylamides.

Novel, well-defined organic arsenical homopolymers (D = 1.10-1.40) have been synthesised via RAFT polymerisation. Copolymerisation of the As-functional monomer with dimethylacrylamide yielded non-toxic polymer scaffolds (D ≈ 1.10) that could be manipulated in response to pH and undergo sequential reduction and substitution in the presence of thiols including cysteine and glutathione.