Subject(s)
Antibodies, Antineutrophil Cytoplasmic/blood , Microscopic Polyangiitis/complications , Pericardial Effusion/etiology , Adrenal Cortex Hormones/therapeutic use , Cardiomegaly/complications , Creatinine/therapeutic use , Cyclophosphamide/therapeutic use , Diabetes Complications/blood , Diabetic Nephropathies/etiology , Female , Glomerulonephritis, Membranoproliferative/drug therapy , Glomerulonephritis, Membranoproliferative/etiology , Humans , Hypertension/complications , Immunosuppressive Agents/therapeutic use , Microscopic Polyangiitis/blood , Microscopic Polyangiitis/drug therapy , Microscopic Polyangiitis/immunology , Middle Aged , Nephritis, Interstitial/drug therapy , Nephritis, Interstitial/etiologyABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications , Pericardial Effusion/complications , Microscopic Polyangiitis/physiopathology , Renal Insufficiency/etiologyABSTRACT
No disponible
Subject(s)
Humans , Female , Aged, 80 and over , Digoxin/toxicity , Renal Insufficiency, Chronic/complications , Risk Factors , Hyperkalemia/complications , Hypercalcemia/complicationsSubject(s)
Anti-Arrhythmia Agents/adverse effects , Digoxin/adverse effects , Aged, 80 and over , Female , HumansABSTRACT
No disponible
No disponible
Subject(s)
Humans , Male , Middle Aged , Renal Dialysis , Renal Insufficiency, Chronic/therapy , Behcet Syndrome/complications , Hepatitis C, Chronic/complicationsABSTRACT
No disponible
No disponible
Subject(s)
Female , Aged , Humans , Catheterization/adverse effects , Renal Dialysis/adverse effects , Foreign-Body Migration/complications , Catheters, Indwelling/adverse effects , Foreign BodiesABSTRACT
Bone mass (BMD) may be evaluated by digital X-ray radiogrammetry (DXR) which it is estimated from multiple cortical measures carried out on five regions of interest over a simple hand-forearm X-ray film. We included 168 HD patients (108 men and 60 women; 63 +/- 14 and 66 +/- 12 years old respectively--p < 0.05-) coming from seven HD units in Asturias. We performed a hand-forearm X-ray, an epidemiologic questionnaire and we revised their medical and analytical records. As the normative data we used the measurements of a random sample of 247 subjects from our own population. The prevalence of osteoporosis was 7% and 40% in men and women respectively. BMD was correlated with weight (r = 0.346), time on HD (r = -0.188), time on treatment (r = -0.235). The porosity was correlated with PTH levels.
Subject(s)
Absorptiometry, Photon , Bone Density , Chronic Kidney Disease-Mineral and Bone Disorder/diagnostic imaging , Osteoporosis/diagnostic imaging , Renal Dialysis , Adult , Aged , Biomarkers , Body Weight , Bone and Bones/chemistry , Bone and Bones/diagnostic imaging , Bone and Bones/pathology , Chronic Kidney Disease-Mineral and Bone Disorder/epidemiology , Chronic Kidney Disease-Mineral and Bone Disorder/etiology , Chronic Kidney Disease-Mineral and Bone Disorder/pathology , Female , Hemodialysis Units, Hospital/statistics & numerical data , Humans , Hyperparathyroidism, Secondary/epidemiology , Hyperparathyroidism, Secondary/etiology , Hyperparathyroidism, Secondary/metabolism , Kidney Failure, Chronic/complications , Kidney Failure, Chronic/therapy , Male , Middle Aged , Osteoporosis/blood , Osteoporosis/epidemiology , Osteoporosis/etiology , Osteoporosis/pathology , Parathyroid Hormone/blood , Prevalence , Reference Values , Renal Dialysis/adverse effects , Sampling Studies , Spain/epidemiology , Surveys and Questionnaires , Time FactorsABSTRACT
Dialysis patients have bone metabolic disorders and a higher prevalence of fractures, principally peripheral fractures. However, there are few studies focusing on the prevalence of vertebral fractures. Moreover, aortic calcifications are very common and are an independent predictive factor of vascular morbidity and mortality. The objective of this study was to assess the prevalence of vertebral fractures and vascular calcifications in haemodialysis (HD) patients (n = 99), in comparison with a random sample of general population of similar age and from the same geographical area (n = 624) and study their relationship with clinical, biochemical and therapeutical data. The prevalence of vertebral fractures in HD patients and general population was 19.1% and 24.1% respectively (non-significant statistical differences). In both, sexes, the presence of vertebral fractures was positively associated with age, mean maximum Ca, mean maximum CaxP. In women, time in HD was positively associated as well. On the other hand, the prevalence of aortic calcifications was much higher in HD patients (77.9% vs 37.5%, p < 0.001). HD was a risk factor for aortic calcification in women [OR = 7.7 (IC 95% = 2.6-22.9)] as in men [OR = 5 (IC 95% = 1.9-12.9)]. Severe vascular calcifications were more frequent in HD patients, it reached 57.4% compared with 17% of general population (p < 0.001). Both, in women (64.5% vs 13.3% p < 0.001) and in men (51.4% vs 20.9%), respectively (p < 0.001). In conclusion, the prevalence of vertebral fractures was similar in HD patients and in general population. Nevertheless, frequency and severity of aortic calcifications was higher in HD patients.
Subject(s)
Aortic Diseases/epidemiology , Calcinosis/epidemiology , Fractures, Spontaneous/epidemiology , Renal Dialysis/adverse effects , Spinal Fractures/epidemiology , Aged , Aged, 80 and over , Aortic Diseases/etiology , Calcinosis/etiology , Calcium/blood , Comorbidity , Female , Fractures, Spontaneous/etiology , Humans , Hyperparathyroidism, Secondary/complications , Kidney Failure, Chronic/complications , Kidney Failure, Chronic/therapy , Lipids/blood , Male , Middle Aged , Odds Ratio , Phosphorus/blood , Prevalence , Random Allocation , Risk Factors , Sampling Studies , Spain/epidemiology , Spinal Fractures/etiologyABSTRACT
La radiogrametría radiológica digital (DXR) mide la masa ósea (DMO) a partir de múltiples mediciones del espesor de la cortical en cinco regiones de interés de una radiografía que incluya mano y antebrazo. Se incluyeron 168 pacientes en hemodiálisis (108 hombres y 60 mujeres; 63 ± 14 y 66 ± 12 años respectivamente p < 0,05) procedentes de 7 Unidades de Diálisis de Asturias. Se les realizó una radiografía de mano y antebrazo, un cuestionario epidemiológico y se revisó la historia clínica. Los valores de referencia se obtuvieron de una muestra aleatoria de nuestra población (n = 247). La prevalencia de osteoporosis fue del 7% y 40% en hombres y mujeres respectivamente. La DMO se correlacionó con el peso (r = 0,346), tiempo en diálisis (r = -0,188) y tiempo en tratamiento (r = -0,235). La porosidad fue dependiente del grado de hiperparatiroidismo (AU)
Bone mass (BMD) may be evaluated by digital X-ray radiogrammetry (DXR) which it is estimated from multiple cortical measures carried out on five regions of interest over a simple hand forearm X-ray film. We included 168 HD patients (108 men and 60 women; 63 ± 14 and 66 ± 12 years old respectively p <0.05) coming from seven HD units in Asturias. We performed a hand-forearm X-ray, an epidemiologic questionnaire and we revised their medical and analytical records. As the normative data we used the measurements of a random sample of 247 subjects from our own population. The prevalence of osteoporosis was 7% and 40% in men and women respectively. BMD was correlated with weight (r = 0.346), time on HD (r = -0.188), time on treatment (r = -0.235). The porosity was correlated with PTH levels (AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Bone Density , Osteoporosis , Chronic Kidney Disease-Mineral and Bone Disorder , Renal Dialysis/adverse effects , Parathyroid Hormone/blood , Hyperparathyroidism, Secondary/epidemiology , Hyperparathyroidism, Secondary/etiology , Hyperparathyroidism, Secondary/metabolism , /statistics & numerical data , Biomarkers , Body Weight , Bone and Bones/chemistry , Bone and Bones/pathology , Bone and Bones , Osteoporosis/blood , Osteoporosis/epidemiology , Osteoporosis/etiology , Osteoporosis/pathology , Chronic Kidney Disease-Mineral and Bone Disorder/epidemiology , Chronic Kidney Disease-Mineral and Bone Disorder/etiology , Chronic Kidney Disease-Mineral and Bone Disorder/pathology , Time Factors , Spain/epidemiology , Sampling Studies , Reference Values , Kidney Failure, Chronic/therapy , Kidney Failure, Chronic/complications , PrevalenceABSTRACT
Los pacientes en diálisis presentan alteraciones del metabolismo óseo y una mayor prevalencia de fracturas, fundamentalmente periféricas; sin embargo, hay pocos estudios realizados que cuantifiquen la prevalencia de fracturas vertebrales. Además, las calcificaciones aórticas son muy frecuentes y representan un factor predictivo independiente de morbilidad y mortalidad vascular. El objetivo del estudio fue conocer la prevalencia de fracturas vertebrales y calcificaciones vasculares en pacientes en hemodiálisis (HD) (n = 99), compararla con una muestra aleatoria de población general de edad similar y de la misma área geográfica (n = 624) y estudiar su relación con datos clínicos, bioquímicos y terapéuticos. La prevalencia de fracturas vertebrales en pacientes en HD y en la población general fue del 19,1% y 24,1% respectivamente (diferencias no significativas). En ambos sexos, las fracturas vertebrales se correlacionaron positivamente con la edad, Ca máximo medio, CaxP máximo medio. En mujeres, también se relacionaron con el tiempo en diálisis. Por el contrario, la prevalencia de calcificaciones aórticas fue muy superior en pacientes en HD (77,9% vs 37,5%, p < 0,001). La HD fue un factor de riesgo de calcificaciones aórticas tanto en mujeres [OR = 7,7 (IC 95% = 2,6-22,9)] como en hombres [OR = 5 (IC 95% = 1,9-12,9)]. Las calcificaciones vasculares severas fueron más frecuentes en pacientes en diálisis alcanzando un 57,4%, frente a un 17% de la población normal (p < 0,001), tanto en mujeres (64,5% vs 13,3% p < 0,001) como en hombres (51,4% vs 20,9%), respectivamente (p < 0,001). En conclusión, la prevalencia de fracturas vertebrales fue similar en pacientes en HD y en la población general, por el contrario la frecuencia y severidad de calcificaciones aórticas fue mayor en pacientes en HD (AU)
Dialysis patients have bone metabolic disorders and a higher prevalence of fractures, principally peripheral fractures. However, there are few studies focusing on the prevalence of vertebral fractures. Moreover, aortic calcifications are very common and are an independent predictive factor of vascular morbidity and mortality. The objective of this study was to assess the prevalence of vertebral fractures and vascular calcifications in haemodialysis (HD) patients (n = 99), in comparison with a random sample of general population of similar age and from the same geographical area (n = 624) and study their relationship with clinical, biochemical and therapeutical data. The prevalence of vertebral fractures in HD patients and general population was 19.1% and 24.1% respectively (non-significant statistical differences). In both, sexes, the presence of vertebral fractures was positively associated with age, mean maximum Ca, mean maximum CaxP. In women, time in HD was positively associated as well. On the other hand, the prevalence of aortic calcifications was much higher in HD patients (77.9% vs 37.5%, p < 0.001). HD was a risk factor for aortic calcification in women [OR = 7,7 (IC 95% = 2.6-22.9)] as in men [OR = 5 (IC 95% = 1.9-12.9)]. Severe vascular calcifications were more frequent in HD patients, it reached 57,4% compared with 17% of general population (p < 0.001). Both, in women (64,5% vs 13,3% p < 0,001) and in men (51,4% vs 20,9%), respectively (p < 0,001). In conclusion, the prevalence of vertebral fractures was similar in HD patients and in general population. Nevertheless, frequency and severity of aortic calcifications was higher in HD patients (AU)