1.
Clin Nephrol
; 62(6): 481-2, 2004 Dec.
Article
in English
| MEDLINE
| ID: mdl-15630912
2.
Clin Exp Pharmacol Physiol Suppl
; 5: 47-55, 1979.
Article
in English
| MEDLINE
| ID: mdl-400971
ABSTRACT
Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described. Severe methotrexate toxicity occurred in two of these patients. High dose methotrexate would appear contra-indicated in situations where massive tumour lysis is possible.
Subject(s)
Methotrexate/adverse effects , Adolescent , Adult , Calcium/metabolism , Humans , Leucovorin/therapeutic use , Lymphoma, Large B-Cell, Diffuse/drug therapy , Male , Methotrexate/administration & dosage , Middle Aged , Phosphates/metabolism , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
3.
Med J Aust
; 1(15): 548, 1976 Apr 10.
Article
in English
| MEDLINE
| ID: mdl-933949