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Trends Parasitol ; 39(8): 622-625, 2023 08.
Article in English | MEDLINE | ID: mdl-37302957

ABSTRACT

Protein disulfide isomerases (PDIs) ensure that specific substrate proteins are correctly folded. PDI activity plays an essential role in malaria transmission. Here we provide an overview of the role of PDIs in malaria-causing Plasmodium parasites and outline why PDI inhibition could be a novel way to treat malaria and prevent transmission.


Subject(s)
Malaria , Plasmodium , Humans , Protein Disulfide-Isomerases/metabolism , Malaria/drug therapy , Malaria/prevention & control , Plasmodium/metabolism
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