Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Cancer Res ; 61(11): 4315-9, 2001 Jun 01.
Article in English | MEDLINE | ID: mdl-11389051

ABSTRACT

The development and growth of prostate cancer depends on the androgen receptor and its high-affinity binding of dihydrotestosterone, which derives from testosterone. Most prostate tumors regress after therapy to prevent testosterone production by the testes, but the tumors eventually recur and cause death. A critical question is whether the androgen receptor mediates recurrent tumor growth after androgen deprivation therapy. Here we report that a majority of recurrent prostate cancers express high levels of the androgen receptor and two nuclear receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. Overexpression of these coactivators increases androgen receptor transactivation at physiological concentrations of adrenal androgen. Furthermore, we provide a molecular basis for this activation and suggest a general mechanism for recurrent prostate cancer growth.


Subject(s)
Neoplasm Recurrence, Local/metabolism , Neoplasms, Hormone-Dependent/metabolism , Prostatic Neoplasms/metabolism , Receptors, Androgen/physiology , Aged , Androgen Antagonists/therapeutic use , Animals , Dihydrotestosterone/pharmacology , Histone Acetyltransferases , Humans , Male , Mice , Mice, Nude , Middle Aged , Neoplasm Recurrence, Local/pathology , Neoplasms, Hormone-Dependent/pathology , Neoplasms, Hormone-Dependent/therapy , Nuclear Receptor Coactivator 1 , Nuclear Receptor Coactivator 2 , Orchiectomy , Prostatic Hyperplasia/metabolism , Prostatic Hyperplasia/pathology , Prostatic Neoplasms/pathology , Prostatic Neoplasms/therapy , Receptors, Androgen/biosynthesis , Testosterone/pharmacology , Transcription Factors/biosynthesis , Transcription Factors/genetics , Transcriptional Activation , Transplantation, Heterologous
SELECTION OF CITATIONS
SEARCH DETAIL
...