Analysis of Sprint Ski Mountaineering Performance.

Ski mountaineering sprint competitions are short individual races involving 3 uphill sections (U), 3 transitions (T), and a final descent. To date, relatively little is known about this novel Olympic discipline, and here we examined (1) the contribution of the time spent on U, T, and final descent to overall finishing time and (2) the potential relationships with final ranking. During the different rounds of 2 International Ski Mountaineering Federation World Cup sprint competitions, male and female ski mountaineers were video recorded. Correlation and multiple linear regression analyses were used to investigate the impact of U, T, and final descent on the best overall finishing time. Linear-mixed model analysis was applied to explore potential interactions between section times, rounds, and final ranking. Overall, U (r = .90-.97) and T (r = .57-.89) were closely correlated with the best overall finishing time (all P < .05). U explained approximately 80% to 90% of the variation in the best finishing time for both sexes, with U + T explaining approximately 95% to 98% of this variation. In each successive round, the ski mountaineers eliminated were all slower on U than the Top 3 (all P < .05). The fastest skiers increased their performance on U in the later rounds of the competitions, while those eliminated showed a tendency toward a decrease. Our findings reveal that world-class sprint ski mountaineers conduct transitions optimally and perform effectively uphill. Training for such competitions should aim to improve short supramaximal uphill performance (∼1.5-2.5 min), ensuring that this does not decline with multiple efforts. These insights into ski mountaineering sprint performance are of considerable value in connection with training for the 2026 Winter Olympics.

The effects of a 6-hour ultra-endurance run on postexercise parasympathetic reactivation responses.

BACKGROUND: Alterations in cardiac autonomic control reflecting depressed parasympathetic activity have been previously reported after ultra-endurance events at rest and during dynamic tasks assessing cardiac autonomic responsiveness. This study investigated the impact of a 6-hour ultra-endurance run on parasympathetic reactivation indices, using an exercise-recovery transition approach. METHODS: Nine trained runners (VO2max 67±12 mL/kg/min) completed a 6-hour run (EXP) whilst other six runners (VO2max 66±10 mL/kg/min) served as a control (CON). Before (PRE) and after the run/control period (POST) participants completed standard cardiac autonomic activity assessments. Postexercise parasympathetic reactivation was assessed by means of heart rate recovery (HRR) and vagal-related time-domain HRV indices. RESULTS: HR was increased at rest (P<0.001, ES=3.53), during exercise (P<0.05, ES=0.38) and recovery (all P<0.001, ES from 0.91 to 1.46) at POST in EXP and not in CON (all P>0.05). At POST vagal-related HRV indices were significantly decreased at rest (P<0.001, ES from -2.38 to -3.54) and during postexercise recovery (all P<0.001, ES from -0.97 to -1.58) only in EXP. HRR at 30 and 60 s were markedly reduced at POST in EXP both when expressed in bpm and normalized for the exercising HR (all P<0.001, ES from -1.21 to -1.74). CONCLUSIONS: A 6-hour run markedly impacted upon postexercise parasympathetic reactivation responses causing a decrease in HRR and HRV recovery indices. For the first time, this study attested blunted postexercise parasympathetic reactivation responses following an acute bout of ultra-endurance exercise.

Participation and performance by women and men in ski-mountaineering sprint races during the past decade.

BACKGROUND: The sprint is one of the two ski-mountaineering disciplines that will be held at the coming Milano Cortina 2026 Winter Olympics (Italy). To date little information exists on this novel Olympic discipline. METHODS: We characterized retrospectively the participation and performance in international male and female ski mountaineering sprint races from November 2012 to April 2022. Potential associations between sex and season with participation, as well as between sex, period, round and final ranking with parameters of performance were examined with linear-mixed models. RESULTS: The minimal performance time required for success (i.e., being eligible for the next round/winning a medal) decreased progressively from the qualifications (Qs) to the final (F). Finalists adopted a conservative strategy in the Qs, improving their performance in the quarter-finals (QFs) and semifinals (SFs). The best and second-best male skier and the best female skier improved their performances even further in the F, which appears to be a key feature for success. For women, the number of participants and level of competition increased over the decade, whereas male participation did not. During the last two seasons, male sprint winners performed relatively more slowly in the preliminary rounds leaving more room for improvement in the F, which could reflect increased specialization in this discipline. CONCLUSIONS: Our findings provide novel insights into ski-mountaineering sprint races that can guide competition strategies and could be of considerable importance in connection with the Milano Cortina 2026 Winter Olympics (Italy).

Effects of low vs. moderate dose of recreational football on cardiovascular risk factors.

This study aimed to compare the effectiveness of recreational football performed once (LOW) vs. twice (MOD) a week on cardiovascular risk factors in healthy, sedentary men. Body composition, resting blood pressure, blood lipid profile and maximal oxygen consumption (VO2max) were measured at baseline, after a 12-week control and training period, using an interrupted time-series study (study 1, n = 18: n = 8, LOW and n = 10, MOD) nested in a randomized parallel trial (study 2, n = 34: n = 18 LOW and n = 16 MOD). After the intervention in study 1, LDL-cholesterol (-12.3 mg·dL-1 [-22.7 to -2.0]) and VO2max (4.5 ml·kg-1·min-1 [1.2-7.8 ]) changed in LOW whereas differences were found in weight (-2.1 kg [-3.7 to -0.4]), BMI (-0.7 kg·m-2 [-1.2 to -0.1]), total cholesterol (-22.2 mg·dL-1 [-36.0 to -8.4]), no-HDL-cholesterol (-17.5 mg·dL-1 [-30.5 to -4.5]), LDL-cholesterol (-14.9 mg·dL-1 [-23.6 to -6.2]) and VO2max (5.7 ml·kg-1·min-1 [2.8-8.6]) in MOD. Study 2 showed no evidence of differences between groups. Our results therefore suggest positive health effects of recreational football even when performed at low frequency as it can happen in real context.Highlights Moderate and high amount of recreational football practice (i.e. 2 or 3 h a week) have been shown to be effective to improve health-related factors in both healthy and unhealthy people.Scarce data are present regarding the effect of a low frequency of recreational football practice (i.e. 1 h a week) that is often usual in a real context.Our results showed the practice of recreational football, once a week, is effective for improving some cardiovascular risk factors (maximal oxygen consumption and LDL-cholesterol) in sedentary, healthy middle-aged men.Moreover, practising recreational football once or twice a week seems to lead to similar positive health adaptations.

Assessment of bike handling during cycling individual time trials with a novel analytical technique adapted from motorcycle racing.

A methodology to study bike handling of cyclists during individual time trials (ITT) is presented. Lateral and longitudinal accelerations were estimated from GPS data of professional cyclists (n = 53) racing in two ITT of different length and technical content. Acceleration points were plotted on a plot (g-g diagram) and they were enclosed in an ellipse. A correlation analysis was conducted between the area of the ellipse and the final ITT ranking. It was hypothesised that a larger area was associated with a better performance. An analytical model for the bike-cyclist system dynamics was used to conduct a parametric analysis on the influence of riding position on the shape of the g-g diagram. A moderate (n = 27, r = -0.40, p = 0.038) and a very large (n = 26, r = -0.83, p < 0.0001) association were found between the area of the enclosing ellipse and the final ranking in the two ITT. Interestingly, this association was larger in the shorter race with higher technical content. The analytical model suggested that maximal decelerations are highly influenced by the cycling position, road slope and speed. This investigation, for the first time, explores a novel methodology that can provide insights into bike handling, a large unexplored area of cycling performance.

Exercising at the time of the COVID-19 pandemic: acute physiological, perceptual and performance responses of wearing face masks during sports activity.

BACKGROUND: The COVID-19 pandemic requires the adoption of strict preventive measures, such as wearing a protective face mask, but few studies investigated its impact during exercise. We investigated the effects of wearing a protective face mask while exercising at different intensities and verified whether differences between two types of protective face masks exist. METHODS: Twenty subjects performed 4-min running at 8 km•h-1 and at 10 km•h-1, 8 x 90-m Intermittent running bouts and the Yo-Yo Intermittent Recovery Test Level-1, while wearing either a surgical mask, a sports-reusable mask or no mask. Physiological responses (HR, [La], SpO2), overall and breathlessness perceived exertion and YYIRT1-distance were assessed. RESULTS: Breathlessness RPE was greater with surgical than without mask at the end of the run at 8 km•h-1 (+7.18 [3.21, 11.50]) and with both surgical and sports-reusable mask than without mask at the end of the run at 10 km•h-1 (+8.09 [4.09, 12.60] and +8.21 [4.53, 12.70]) and intermittent exercise (+11.10 [6.41, 16.10] and +10.50 [6.18, 15.30]). Overall RPE was greater with surgical than without mask at the end of the run at 8 (+3.71 [1.15, 6.91]) and 10 km•h-1 (+5.29 [2.26, 8.85]). Furthermore, YYIRT1 performance was lower with surgical (-150 m [44, 240]) and sports-reusable mask (-201 m [108, 286]) than without mask. CONCLUSIONS: Regardless of exercise intensity and mask type, wearing a protective face mask mostly affects perceptual responses, also causing a performance reduction during maximal exercise. These findings must be considered when prescribing/practicing exercise while wearing a protective face mask.

Eager to set a record in a vertical race? Test your VO2max first!

We investigated the relationship between maximal oxygen consumption (VO2max) and performance in vertical races (VRs). In total, 270 performances, from 26 VRs, and cardiopulmonary data of 64 highly-trained mountain runners (53 M, V O2max: 75.7±5.8 mL/min/kg; 11 F: 65.7±3.4 mL/min/kg), collected over a 11-year period (2012-2022), were analysed. The relationship between performance and VO2max was modelled separately for national (NVRs), international (IVRs), and VRs of current pole-unassisted and pole-assisted vertical kilometre (VK) records (RVRs). Three different (p<0.001) exponential models described the relationship between performance and VO2max in IVRs (R2=0.96, p<0.001), NRs (R2=0.91, p<0.001) and RVRs (R2=0.97, p<0.001). Estimated VO2max requirements (with 95% CI) to win/set a record time in IVRs were 86.2(85.3-87.1)/89.4(88.2-90.5) and 74.0(73.6-74.4)/76.8(76.4-77.3) mL/min/kg, for males and females, respectively, 86.1(85.0-87.1)/90.4(89.0-91.8) and 74.8(74.2-75.3)/77.1(77.6-77.7) mL/min/kg in RVRs, decreasing to 83.7(82.5-84.9)/87.6(86.0-89.2) and 66.8(65.9-67.7)/70.7(70.1-71.4) mL/min/kg in NVRs. Our study also suggested a tendency towards a non-uniform variation in the metabolic demand of off-road running, likely attributable to the different features of the VRs (e.g., terrain, technical level, use of poles). These data provide mean VO2max requirements for mountain runners to win and establish new records in VRs and stimulate new research on the energy cost of off-road running.

Effects of Breaking up Deskwork with Physical Activity Combined with Tea Consumption on Cerebrovascular Function, Mood, and Affect

Abstract Background: Prolonged sitting, typical of desk work, decreases cerebral blood flow (CBF), mood and affect. Conversely, short physical activity breaks from sitting may prevent these detrimental effects and provide cardiometabolic benefits. Objective: We evaluated the effect of interrupting prolonged sitting with short breaks of light physical activity combined with tea consumption on CBF, cerebral autoregulation (CA), mood, and affect in desk workers. Methods: Nineteen healthy desk workers (ten male, 27±10 years) performed desk work in a laboratory for six hours on two separate intervention days: tea breaks (TEA-BREAK: short walk combined with ingestion of one cup of tea every hour) and sedentary (SED: ingestion of one cup of water every hour, while seated). Before and after desk work, we assessed mean arterial pressure (MAP), middle cerebral artery blood velocity (MCAv) and CA. Questionnaires were used to assess mood (Bond & Lader, PANAS) and affect (Affect grid) before and after the intervention. Data are expressed as mean ± standard deviation. Two-way ANOVA with repeated measurements followed by Sidak post hoc test was used for data analysis. Paired Student's t-test was also used to compare changes (Δ) between trials. Statistical significance was at p<0.05. Results: Desk work increased MAP (4.6±4.6 Δ mmHg; P<0.05), and decreased MCAv (-5.2±7.0 Δ cm/s; P<0.05), with no difference between interventions in these parameters. TEA-BREAKS, but not SED, decreased gain (-0.08±0.12 Δ cm.s−1.mmHg.−1) and increased phase (5.26±8.84 Δ radians) at very low frequency (P<0.05), but not at low frequency. Small changes in positive affect were found after the six hours of desk work (-5.5±7.3 Δ scale; P<0.05), with no differences between interventions. Conclusion: Changes in MCAv and positive affect induced by prolonged desk work could not be prevented by TEA-BREAKS. However, TEA-BREAKS improved CA, suggesting a higher efficiency in maintaining MCAv in response to blood pressure fluctuations.

Acute exercise-induced changes in cardiac function relates to right ventricular remodeling following 12-wk hypoxic exercise training.

Repeated ventricular exposure to alterations in workload may relate to subsequent cardiac remodeling. We examined whether baseline acute changes in right (RV) and left ventricular (LV) function relate to chronic cardiac adaptation to 12-wk exercise training. Twenty-one healthy individuals performed 12-wk high-intensity endurance running training under hypoxia (fraction of inspired oxygen: 14.5%). Resting transthoracic echocardiography was performed before and after the training program to assess ventricular structure, function, and mechanics (including strain-area/volume loops). In addition, we examined systolic cardiac function during recumbent exercise under hypoxia at baseline (heart rate of 110-120 beats/min, "stress echocardiography"). Fifteen individuals completed training (22.0 ± 2.4 yr, 10 males). Hypoxic exercise training increased RV size, including diameter and area (all P < 0.05). With exception of an increase in RV fractional area change (P = 0.03), RV function did not change post-training (all P > 0.05). Regarding the RV strain-area loop, lower systolic and diastolic slopes were found post-training (P < 0.05). No adaptation in LV structure, function, or mechanics was observed (all P > 0.05). To answer our primary aim, we found that a greater increase in RV fractional area change during baseline stress echocardiography (r = -0.67, P = 0.01) inversely correlated with adaptation in RV basal diameter following 12-wk training. In conclusion, 12-wk high-intensity running hypoxic exercise training induced right-sided structural remodeling, which was, in part, related to baseline increase in RV fractional area change to acute exercise. These data suggest that acute cardiac responses to exercise may relate to subsequent RV remodeling after exercise training in healthy individuals.NEW & NOTEWORTHY During exercise, the right ventricle is exposed to a disproportionally higher wall stress than the left ventricle, which is further exaggerated under hypoxia. In this study, we showed that 12-wk high-intensity running hypoxic exercise training induced right-sided structural remodeling, which was, in part, related to baseline cardiac increase in RV fractional area change to acute exercise. These data suggest that acute RV responses to exercise are related to subsequent right ventricular remodeling in healthy individuals upon hypoxic training.

Effects of three-exercise sessions in the heat on endurance cycling performance.

PURPOSE: To investigate the effects of a very short-term acclimation protocol (VSTAP) on performance, physiological and perceptual responses to exercise in the heat. METHODS: 12 trained male cyclists (age 31.2 ± 7; weight 71.3 ± 7 kg, VO2max: 58.4 ± 3.7 mL/kg/min) randomly performed two Time to Exhaustion Tests (TTE) at 75% of normothermic peak power output (PPO), one in normothermia (N,18°C-50% RH) and one in the heat (H,35°C-50% RH), before and after a VSTAP intervention, consisting of 3 days-90 min exercise (10min at 30% of PPO+80 min at 50% of PPO) in H (≈4.5h of heat exposure). Performance time of TTEs and physiological and perceptual variables of both TTEs and training sessions (T1, T2 and T3) were evaluated. RESULTS: Magnitude Based Inferences (MBI) revealed 92/6/1% and 62/27/11% chances of positive/trivial/negative effects of VSTAP of improving performance in H (+17%) and in N (+9%), respectively. Heart Rate (HR) decreased from T1 to T3 (p < 0.001) and T2 to T3 (p < 0.001), whereas Tympanic Temperature (TyT) decreased from T1 to T2 (p = 0.047) and from T1 to T3 (p = 0.007). Furthermore, despite the increased tolerance to target Power Output (PO) throughout training sessions, RPE decreased from T1 to T3 (p = 0.032). CONCLUSIONS: The VSTAP determined meaningful physiological (i.e. decreased HR and TyT) and perceptual (i.e. decreased RPE) adaptations to submaximal exercise. Furthermore, showing good chances to improve performance in the heat, it represents a valid acclimation strategy to be implemented when no longer acclimation period is possible. Finally, no cross-over effect of the VSTAP on performance in temperate conditions was detected.

Post-exercise cardiac autonomic and cardiovascular responses to heart rate-matched and work rate-matched hypoxic exercise.

PURPOSE: This study investigated the effect of performing hypoxic exercise at the same heart rate (HR) or work rate (WR) as normoxic exercise on post-exercise autonomic and cardiovascular responses. METHODS: Thirteen men performed three interval-type exercise sessions (5 × 5-min; 1-min recovery): normoxic exercise at 80% of the WR at the first ventilatory threshold (N), hypoxic exercise (FiO2 = 14.2%) at the same WR as N (H-WR) and hypoxic exercise at the same HR as N (H-HR). Autonomic and cardiovascular assessments were conducted before and after exercise, both at rest and during active squat-stand manoeuvres (SS). RESULTS: Compared to N, H-WR elicited a higher HR response (≈ 83% vs ≈ 75%HRmax, p < 0.001) and H-HR a reduced exercise WR (- 21.1 ± 9.3%, p < 0.001). Cardiac parasympathetic indices were reduced 15 min after exercise and recovered within 60 min in N and H-HR, but not after H-WR (p < 0.05). H-WR altered cardiac baroreflex sensitivity (cBRS) both at rest and during SS (specifically in the control of blood pressure fall during standing phases) in the first 60 min after the exercise bout (p < 0.05). Post-exercise hypotension (PEH) did not occur in H-HR (p > 0.05) but lasted longer in H-WR than in N (p < 0.05). CONCLUSIONS: Moderate HR-matched hypoxic exercise mimicked post-exercise autonomic responses of normoxic exercise without resulting in significant PEH. This may relate to the reduced WR and the limited associated mechanical/metabolic strain. Conversely, WR-matched hypoxic exercise impacted upon post-exercise autonomic and cardiovascular responses, delaying cardiac autonomic recovery, temporarily decreasing cBRS and evoking prolonged PEH.

Exercise-Induced Cardiac Fatigue after a 45-Minute Bout of High-Intensity Running Exercise Is Not Altered under Hypoxia.

BACKGROUND: Acute exercise promotes transient exercise-induced cardiac fatigue, which affects the right ventricle and to a lesser extent the left ventricle. Hypoxic exposure induces an additional increase in right ventricular (RV) afterload. Therefore, exercise in hypoxia may differently affect both ventricles. The aim of this study was to investigate the acute effects of a bout of high-intensity exercise under hypoxia versus normoxia in healthy individuals on right- and left-sided cardiac function and mechanics. METHODS: Twenty-one healthy individuals (mean age, 22.2 ± 0.6 years; 14 men) performed 45-min high-intensity running exercise under hypoxia (fraction of inspired oxygen 14.5%) and normoxia (fraction of inspired oxygen 20.9%) in a randomized order. Pre- and post-exercise echocardiography, at rest and during low-to-moderate intensity recumbent exercise ("stress"), was performed to assess RV and left ventricular (LV) cardiac function and mechanics. RV structure, function, and mechanics were assessed using conventional two-dimensional, Doppler, tissue Doppler, speckle-tracking echocardiographic, and novel strain-area loops. RESULTS: Indices of RV systolic function (RV fractional area change, Tricuspid annular plane systolic excursion, RV s', and RV free wall strain) and LV function (LV ejection fraction and LV global longitudinal strain) were significantly reduced after high-intensity running exercise (P < .01). These exercise-induced changes were more pronounced when echocardiography was examined during stress compared with baseline. These responses in RV and LV indices were not altered under hypoxia (P > .05). CONCLUSIONS: There was no impact of hypoxia on the magnitude of exercise-induced cardiac fatigue in the right and left ventricles after a 45-min bout of high-intensity exercise. This finding suggests that any potential increase in loading conditions does not automatically exacerbate exercise-induced cardiac fatigue in this setting.

Talent Development in Young Cross-Country Skiers: Longitudinal Analysis of Anthropometric and Physiological Characteristics.

Introduction: Very little is known about talent development and selection processes in young cross-country skiers. Aim: (1) to analyze the effect of age on anthropometric and physiological parameters in medium-to-high level cross-country skiers during the late teenage period; (2) to describe parameters' trend in selected talents after the late teenage period; (3) to define which characteristics during the late teenage period could discriminate against further talent selection. Method: We found 14 male (M) and nine (F) athletes in our database, identified as talents by regional teams during the late teenage period, who performed the same diagonal-stride roller-skiing incremental test to exhaustion at 17 and 18 years old. Of these, four M and three F teenagers performed four further evaluations, and were selected by the national team. Age effect during the late teenage period was verified on anthropometric and physiological parameters measured at maximal intensity (MAX), first (VT1), and second (VT2) ventilatory thresholds, and 3° and 6° of treadmill incline. An observational analysis allowed to evaluate parameters' trend after the late teenage period in selected athletes, and to determine possible characteristics early discriminating further selection. Results: During the late teenage period, height, weight, and BMI was still raising in M as well as V'O2 at VT2 and 6° of treadmill incline (all P > 0.05). In F, mass-scaled V'O2 MAX increased while heart rate (HR) at MAX and VT2 decreased (all P > 0.05). Since the late teenage period, all selected males showed maximal ventilation volumes, absolute V'O2 at MAX, VT1, and VT2 that were within or above the 75th percentile of their group; the same was found in selected females for mass-scaled V'O2 MAX, VT1, and VT2 time. After the late teenage period, all selected athletes showed an increasing trend for VT2 time, while a decreasing trend for sub-maximal energetic cost, %V'O2 and HR. Discussion: During the late teenage period, males are still completing their maturation process. Since the late teenage period, some physiological parameters seem good indicators to early discriminate for further talents. A progressive increase in skiing efficiency was demonstrated in developing talents of both sexes after the late teenage period.

Post-Exercise Hypotension and Reduced Cardiac Baroreflex after Half-Marathon Run: In Men, but Not in Women.

We examined whether trained women exhibit similar cardiovascular and cardiac baroreflex alterations after a half-marathon compared to men. Thirteen women (39.1 ± 9.3 years; 165 ± 6 cm; 58.2 ± 7.5 kg; maximal aerobic speed (MAS): 13.7 ± 2.2 km·h-1) and 12 men (45.7 ± 10.5 years; 178 ± 7 cm; 75.0 ± 8.3 kg; MAS: 15.8 ± 2.2 km·h-1) ran an official half-marathon. Before and 60-min after, cardiovascular variables, parasympathetic (heart rate variability analysis) modulation and cardiac baroreflex function (transfer function and sequence analyses) were assessed during supine rest and a squat-stand test. Running performance was slower in women than in men (120 ± 19 vs. 104 ± 14 min for women and men, respectively). However, when expressed as a percentage of MAS, it was similar (78.1 ± 4.6% and 78.2 ± 5.4% of MAS for women and men, respectively). Before the run, women exhibited lower mean blood pressure (BP), cardiac output (CO) and stroke volume (SV) compared to men, together with higher parasympathetic indexes. After the race, parasympathetic indexes decreased in both sexes, but remained higher in women. Reduced SV, systolic BP and cardiac baroreflex were observed in men but not in women. Contrary to men, a competitive half-marathon did not trigger post-exercise hypotension and a reduced cardiac baroreflex in women.

The acute and chronic effects of high-intensity exercise in hypoxia on blood pressure and post-exercise hypotension: A randomized cross-over trial.

BACKGROUND: Acute exercise leads to an immediate drop in blood pressure (BP), also called post-exercise hypotension (PEH). Exercise in hypoxia is related to additional vasodilation, potentially contributing to more profound PEH. Therefore, we investigated the impact of hypoxia versus normoxia on the magnitude of PEH. Second, we examined whether these changes in PEH relate to the BP-lowering effects of 12-week exercise training under hypoxia. METHODS: In this prospective study, 21 healthy individuals (age 22.2 ±â€Š3.0 years, 14 male) performed a 45-minute high-intensity running exercise on 2 different days in a random order, under hypoxia (fraction of inspired oxygen 14.5%) and normoxia (fraction of inspired oxygen 20.9%). BP was examined pre-exercise (t = 0) and at t = 15, t = 30, t = 45, and t = 60 minutes post-exercise. Afterward, subjects took part in a 12-week hypoxic running exercise training program. Resting BP was measured before and after the 12-week training program. RESULTS: Acute exercise induced a significant decrease in systolic BP (systolic blood pressure [SBP], P = .001), but not in diastolic BP (diastolic blood pressure [DBP], P = .113). No significant differences were observed in post-exercise BP between hypoxic and normoxic conditions (SBP, P = .324 and DBP, P = .204). Post-exercise changes in SBP, DBP, and mean arterial pressure significantly correlated to the 12-week exercise training-induced changes in SBP (r = 0.557, P = .001), DBP (r = 0.615, P < .001), and mean arterial pressure (r = 0.458, P = .011). CONCLUSION: Our findings show that hypoxia does not alter the magnitude of PEH in healthy individuals, whilst PEH relates to the BP-lowering effects of exercise. These data highlight the strong link between acute and chronic changes in BP.

Shortening Work-Rest Durations Reduces Physiological and Perceptual Load During Uphill Walking in Simulated Cold High-Altitude Conditions.

Fornasiero, Alessandro, Aldo Savoldelli, Federico Stella, Alexa Callovini, Lorenzo Bortolan, Andrea Zignoli, David A. Low, Laurent Mourot, Federico Schena, and Barbara Pellegrini. Shortening work-rest durations reduces physiological and perceptual load during uphill walking in simulated cold high-altitude conditions. High Alt Med Biol. 21:249-257, 2020. Background: We investigated the effects of two different work-rest durations on the physiological and perceptual responses to a simulated mountain hike in a cold hypoxic environment. Materials and Methods: Twelve healthy nonacclimatized active men (age 31.3 ± 5.3 years, body mass index 22.4 ± 1.5 kg/m2) completed a 80-minute work-matched intermittent exercise on a motorized treadmill (25% incline, fixed self-selected speed), in a simulated mountain environment (-25°C, FiO2 = 11%, ≈5000 m a.s.l.), wearing extreme cold weather gear, once with short (20 × 3 minutes walking with 1 minute rest; SHORT) and once with long (10 × 6 minutes walking with 2 minutes rest; LONG) work-rest durations. Heart rate (HR), pulse oxygen saturation (SpO2), rate of perceived exertion (RPE), and thermal sensation (TS) were assessed throughout the exercise protocols. Cardiac autonomic modulation was assessed before (PRE) and after exercise (POST) in supine position, as well as during standing resting periods by means of HR recovery (HRR) assessment. Results: SpO2 and TS were similar (p > 0.05) in SHORT and LONG protocols. HR and RPE were increased, and HRR reduced during LONG compared to SHORT (p < 0.05). Parasympathetic activity indices were reduced at POST after both protocols (p < 0.05), but to a lesser extent after SHORT (p < 0.05). Conclusions: Reduced work-rest durations are associated with improved perceptual responses and less perturbation of cardiac autonomic balance, compared to longer work-rest durations. Shorter exercise periods from more frequent breaks during hikes at high altitude may represent a valid strategy to limit the impact of exercise under extreme environmental conditions.

Estimating an individual's oxygen uptake during cycling exercise with a recurrent neural network trained from easy-to-obtain inputs: A pilot study.

Measurement of oxygen uptake during exercise ([Formula: see text]) is currently non-accessible to most individuals without expensive and invasive equipment. The goal of this pilot study was to estimate cycling [Formula: see text] from easy-to-obtain inputs, such as heart rate, mechanical power output, cadence and respiratory frequency. To this end, a recurrent neural network was trained from laboratory cycling data to predict [Formula: see text] values. Data were collected on 7 amateur cyclists during a graded exercise test, two arbitrary protocols (Prot-1 and -2) and an "all-out" Wingate test. In Trial-1, a neural network was trained with data from a graded exercise test, Prot-1 and Wingate, before being tested against Prot-2. In Trial-2, a neural network was trained using data from the graded exercise test, Prot-1 and 2, before being tested against the Wingate test. Two analytical models (Models 1 and 2) were used to compare the predictive performance of the neural network. Predictive performance of the neural network was high during both Trial-1 (MAE = 229(35) mlO2min-1, r = 0.94) and Trial-2 (MAE = 304(150) mlO2min-1, r = 0.89). As expected, the predictive ability of Models 1 and 2 deteriorated from Trial-1 to Trial-2. Results suggest that recurrent neural networks have the potential to predict the individual [Formula: see text] response from easy-to-obtain inputs across a wide range of cycling intensities.

Similar cardiovascular and autonomic responses in trained type 1 diabetes mellitus and healthy participants in response to half marathon.

AIMS: This field experiment examined whether trained people with type 1 diabetes mellitus (T1D) have similar cardiovascular and baroreflex alterations after a 21-km running race when compared to healthy people. METHODS: Nine T1D (39.0 ± 11.1 yr; 175.0 ± 10.2 cm; 70.8 ± 8.7 kg) were matched with 9 healthy participants (42.4 ± 5.8 yr; 175.7 ± 6.7 cm; 72.1 ± 8.5 kg) who ran an official half-marathon. Before and 1-hour after the race, cardiovascular variables, sympathetic activity (catecholamines), parasympathetic (heart rate variability analysis) modulation and cardiac baroreflex function (transfer function analysis) were assessed during supine rest and a squat stand test (forced blood pressure change). RESULTS: Performance time and weight loss [104.0 ± 13.2 and 111.0 ± 18.7 min; -2.57 ± 1.05 kg (-1.88 ± 0.88%) and -2.29 ± 1.15 kg (-1.59 ± 0.59%)] for healthy and T1D participants, respectively) were similar. Before running, no significant differences in any cardiovascular or autonomic variables were noted between the groups. After 1 h of recovery, both groups exhibited post-exercise hypotension, accompanied by increased sympathetic activity, decreased parasympathetic modulation, and reduced cardiac baroreflex sensitivity. CONCLUSIONS: Our results showed that the pattern of change in cardiovascular and autonomic nervous activity to strenuous exercise are well maintained in T1D participants with a training history of at least 5 years.

Cardiac Autonomic and Physiological Responses to Moderate- intensity Exercise in Hypoxia.

Exercise physiological responses can be markedly affected by acute hypoxia. We investigated cardiac autonomic and physiological responses to different hypoxic training protocols. Thirteen men performed three exercise sessions (5×5-min; 1-min passive recovery): normoxic exercise at 80% of the power output (PO) at the first ventilatory threshold (N), hypoxic exercise (FiO2=14.2%) with the same PO as N (HPO) and hypoxic exercise at the same heart rate (HR) as N (HHR). PO was lower in HHR (21.1±9.3%) compared to N and HPO. Mean HR was higher in HPO (154±11 bpm, p<0.01) than N and HHR (139±10 vs. 138±9 bpm; p=0.80). SpO2 was reduced (p<0.01) to a similar extent (p>0.05) in HPO and HHR compared to N. HR recovery (HRR) and HR variability indices were similar in N and HHR (p>0.05) but reduced in HPO (p<0.05), mirroring a delayed parasympathetic reactivation. Blood lactate and ventilation were similar in N and HHR (p>0.05) and increased in HPO (p<0.001). During recovery oxygen consumption and ventilation were similar in N and HHR (p>0.05) and increased in HPO (p<0.01). Moderate HR-matched hypoxic exercise triggers similar cardiac autonomic and physiological responses to normoxic exercise with a reduced mechanical load. On the contrary, the same absolute intensity exercise in hypoxia is associated with increased exercise-induced metabolic stress and delayed cardiac autonomic recovery.