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Adv Mater ; 27(10): 1738-44, 2015 Mar 11.
Article in English | MEDLINE | ID: mdl-25601165

ABSTRACT

Structured hydrogels showing form stability and elastic properties individually tailorable on different length scales are accessible in a one-step process. They support cell adhesion and differentiation and display growing pore size during degradation. In vivo experiments demonstrate their efficacy in biomaterial-induced bone regeneration, not requiring addition of cells or growth factors.


Subject(s)
Absorbable Implants , Biocompatible Materials/chemical synthesis , Bone Regeneration , Hydrogels/chemical synthesis , Animals , Biocompatible Materials/chemistry , Biocompatible Materials/therapeutic use , Bone Regeneration/physiology , Bony Callus/physiopathology , Cell Adhesion/physiology , Cell Differentiation/physiology , Cell Line , Cell Survival , Cells, Cultured , Elasticity , Female , Femur/injuries , Fibroblasts/physiology , Gelatin/chemistry , Humans , Hydrogels/chemistry , Hydrogels/therapeutic use , Materials Testing , Mesenchymal Stem Cells/physiology , Physical Stimulation/instrumentation , Physical Stimulation/methods , Porosity , Rats, Sprague-Dawley
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