A retrospective analysis of malaria deaths in the pre- and intra- COVID 19 pandemic era, Ghana, 2016-2021.

BACKGROUND: Global efforts over the years have resulted in a 27% reduction in malaria incidence and an estimated 51% reduction in malaria mortality since 2000. Meanwhile, COVID-19 pandemic disrupted provision and utilization of malaria services, leading to a surge in malaria incidence and mortality. Globally, 627000 malaria deaths were recorded in 2020, representing about 69000 more deaths compared to 2019. Also, 14 million more cases of malaria were recorded in 2020 compared to 2019. This study sought to determine whether excess malaria deaths were recorded in Ghana during the COVID-19 pandemic era. METHODS: This was a descriptive study on routine malaria mortality data in Ghana for the period 2016 to 2021. Data was retrieved from the District Health Information Management System using a data extraction guide. Excess mortality was defined as occurrence of malaria deaths more than expected value for the period 2020 and 2021. The expected number of mortalities for 2020 and 2021 were determined using 2016 to 2019 average. Excess mortality (P-score) was estimated using the formula: [(reported mortalities-expected mortalities)/expected mortalities X 100%]. Data were summarized and processed in Microsoft excel version 16.0. Malaria mortality in Ghana and its regions was described using tables and line graphs. RESULTS: An average of 535 malaria deaths per year were recorded nationwide from 2016 to 2020. About 50% (1603/3207) of deaths occurred in children aged less than five years. The p-scores for the country were -53% and -58% for 2020 and 2021 respectively. No region recorded excess all-age malaria mortality in 2020, rather significant reduction. Stratified by age, Greater Accra region reported 90% higher than expected deaths among persons aged five years and above in 2020 (p-score = 90%, 95% CI: 21-159). All regions reported reduction in under-five mortality in 2020. No significant excess malaria mortalities were reported among the regions in 2021. CONCLUSION: Although negative p-scores suggested a decline in malaria mortalities nationwide, some regions recorded excess deaths during the COVID-19 pandemic era. There is a need to integrate COVID-19 control activities with malaria control and prevention efforts to mitigate the impact of COVID-19 on malaria case management and mortality.

Implementation of the Affordable Medicines for Malaria Facility (AMFm) in Ghana: processes, challenges and achievements.

In 2004, Ghana adopted Artemisinin-based Combination Therapy (ACT) for the treatment of uncomplicated malaria. The use of ACTs had been low, especially in the private sector, because of higher prices of ACTs. The Affordable Medicine Facility for Malaria Initiative, in which international organizations subsidize ACTs to make them affordable locally, is being implemented in Ghana. We document the processes, challenges, and achievements of this initiative in Ghana based on a review of policies, guidelines, reports, meeting minutes, and an internet search. The review spanned activities from July 2009 to December 2011. Ghana was the first country to receive these subsidized ACTs (called 'co-paid'), and availability of ACTs increased from 31 per cent to 83 per cent nationwide. The price of ACTs dropped from about US$7 to $0.75 for adults and from $5 to $0.5 for children. Misuse of anti-malarials so that they fail to improve health and can spread resistance may occur if the initiative is not well managed. Collaboration with stakeholders, especially the private sector, and implementation of appropriate supportive activities is important with this initiative.