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1.
Osteoarthritis Cartilage ; 25(7): 1055-1061, 2017 07.
Article in English | MEDLINE | ID: mdl-28219714

ABSTRACT

OBJECTIVES: The purpose of the study was to determine if physical activity (PA) is a risk factor for persistent or recurrent hip pain in young and middle-aged persons with and without radiographic findings of cam or pincer morphology (CPM). METHODS: A population sample of persons aged 20-49 with (cases) and without (controls) hip pain in Metro Vancouver, Canada, was selected through random digit dialing (RDD). Self-reported PA was expressed as average energy expenditure (MET-hours) per year, over lifetime. CPM was defined as alpha angle >55°, lateral centre edge angle (LCE) >40°, or positive cross-over sign. RESULTS: Data were obtained for 500 subjects, 269 cases and 231 controls. Prevalence of radiographic CPM was 49% in the cases and 44% in the controls. In a logistic regression model adjusted for age, gender and CPM, total lifetime PA, including occupational, domestic and recreational activities, was significantly associated with hip pain (Odds ratio (OR) 1.30 per 1000 MET-hours, 95% CI 1.15-1.38). The effect of total PA was observed in those with CPM (1.44, 1.17-1.78) and without CPM (1.23, 1.04-1.45). For domestic activities, the association was seen only in those with CPM (significant interaction). When PA was categorized into quartiles, higher levels of PA were associated with a greater risk of pain. CONCLUSIONS: PA, as measured by average energy expenditure over lifetime is a risk factor for hip pain in young and middle-aged persons. For some activities, the risk is likely increased in persons with radiographic evidence of CPM.


Subject(s)
Exercise/physiology , Musculoskeletal Pain/etiology , Adult , Age Distribution , British Columbia/epidemiology , Case-Control Studies , Chronic Pain/epidemiology , Chronic Pain/etiology , Chronic Pain/pathology , Female , Femoracetabular Impingement/complications , Femoracetabular Impingement/epidemiology , Femoracetabular Impingement/pathology , Humans , Male , Middle Aged , Musculoskeletal Pain/epidemiology , Musculoskeletal Pain/pathology , Recurrence , Risk Factors , Sex Distribution , Young Adult
2.
Rheumatol Int ; 36(3): 371-6, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26433895

ABSTRACT

The purpose of this study was to evaluate the validity and reliability of a radiographic diagnosis of femoroacetabular impingement (FAI) by a non-radiologist. Symptomatic FAI is prevalent and thought to be a cause of hip osteoarthritis. However, the diagnosis is often delayed by 1-2 years, in large part because radiographic findings are often subtle and clinicians have been unaware of their significance. The purpose of this study was to evaluate the validity of a radiographic diagnosis of FAI by a non-radiologist. A population-based sample of 701 subjects was recruited in Vancouver, Canada. For the current study, 50 subjects were selected-40 randomly from the population sample and 10 from an orthopedic practice with confirmed FAI. An anterior-posterior pelvis and bilateral Dunn radiographs were acquired and read by a fellowship-trained musculoskeletal radiologist and a third-year medical student who received basic training in radiographic signs of FAI. Three radiographic signs were evaluated: the lateral center edge angle, alpha angle and crossover sign. Validity was assessed using sensitivity and specificity, Bland-Altman limits of agreement and kappa. The sample contained 65% women (n = 31), was 62% Caucasian and 38% Chinese and had a mean age of 38.3 years. For correctly diagnosing FAI, the non-radiologist reader had a sensitivity of 0.83 and specificity of 0.87. Intra-rater κ value was 0.72, and prevalence-adjusted bias-adjusted κ was 0.76. This study provides evidence that a non-radiologist can accurately and reliably identify FAI on plain films.


Subject(s)
Acetabulum/diagnostic imaging , Clinical Competence , Femoracetabular Impingement/diagnostic imaging , Femur/diagnostic imaging , Adult , Anatomic Landmarks , British Columbia , Female , Humans , Male , Observer Variation , Predictive Value of Tests , Reproducibility of Results
3.
Eur J Radiol ; 81(11): 3461-5, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22698712

ABSTRACT

PURPOSE: To describe the frequency of glenoid chondral abnormalities in relation to Hill Sachs (HS) lesions in MR arthrograms of patients with anterior shoulder instability versus controls. Such glenoid lesions can directly impact surgical decision-making and approach, and potentially negatively impact outcome if missed. MATERIALS AND METHODS: Retrospective analysis of direct MR shoulder arthrograms in 165 subjects, (101 with anterior instability/64 controls) was performed independently by 2 blinded musculoskeletal radiologists. Outcome measures were the presence of a HS, anterior labral pathology and glenoid chondral injury. Kappa statistic, Pearson Chi-square and Mann-Whitney analysis were employed for analysis. RESULTS: Inter-observer variability for the presence of HS, labral and chondral lesions was 0.964, 0.965 and 0.858 respectively, with intra-observer variability of 1.0, 0.985 and 0.861 for the principle reader. 58% of patients and 8% of controls had HS (p<0.001). 72% of patients and 25% of controls had anterior labral injury (p<0.001). 36% of instability patients and 10% controls had glenoid chondral lesions (p<0.001). 46% of anterior instability patients with HS defects had chondral injury as opposed to 21% of patients without HS defects (p=0.009). Depth of the HS lesion did not increase the likelihood of a glenoid chondral lesion (p=0.7335). CONCLUSION: In the clinical anterior instability cohort, we demonstrated a statistically significant higher number of HS and glenoid chondral lesions than in controls. In anterior instability patients, the presence of a HS lesion confers a statistically significant greater likelihood of having a glenoid chondral lesion when compared to patients with instability and no HS.


Subject(s)
Cartilage, Articular/pathology , Joint Instability/epidemiology , Joint Instability/pathology , Magnetic Resonance Imaging/statistics & numerical data , Shoulder Dislocation/epidemiology , Shoulder Dislocation/pathology , Adolescent , Adult , British Columbia/epidemiology , Comorbidity , Female , Humans , Incidence , Male , Reproducibility of Results , Risk Assessment , Sensitivity and Specificity , Young Adult
7.
Br J Sports Med ; 43(11): 856-62, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19864590

ABSTRACT

This article reviews the magnetic resonance imaging (MRI) findings of the native and reconstructed anterior cruciate ligament (ACL). MRI is the most accurate non-invasive modality to evaluate the ACL. Tears of the ACL manifest with direct and indirect signs. The reconstructed ACL has several complications including re-tear and anterior arthrofibrosis, which are also accurately assessed using MRI.


Subject(s)
Anterior Cruciate Ligament/anatomy & histology , Joint Diseases/pathology , Anterior Cruciate Ligament/surgery , Anterior Cruciate Ligament Injuries , Humans , Joint Diseases/surgery , Magnetic Resonance Imaging , Rupture/pathology , Rupture/surgery
11.
Osteoporos Int ; 20(3): 445-53, 2009 Mar.
Article in English | MEDLINE | ID: mdl-18661091

ABSTRACT

UNLABELLED: We examined the contributions of femoral neck cortical and trabecular bone to proximal femur failure load. We found that trabecular bone mineral density explained a significant proportion of variance in failure load after accounting for total bone size and cortical bone mineral content or cortical area. INTRODUCTION: The relative contribution of femoral neck trabecular and cortical bone to proximal femur failure load is unclear. OBJECTIVES: Our primary objective was to determine whether trabecular bone mineral density (TbBMD) contributes to proximal femur failure load after accounting for total bone size and cortical bone content. Our secondary objective was to describe regional differences in the relationship among cortical bone, trabecular bone, and failure load within a cross-section of the femoral neck. MATERIALS AND METHODS: We imaged 36 human cadaveric proximal femora using quantitative computed tomography (QCT). We report total bone area (ToA), cortical area (CoA), cortical bone mineral content (CoBMC), and TbBMD measured in the femoral neck cross-section and eight 45 degrees regions. The femora were loaded to failure. RESULTS AND OBSERVATIONS: Trabecular bone mineral density explained a significant proportion of variance in failure load after accounting for ToA and then either CoBMC or CoA respectively. CoBMC contributed significantly to failure load in all regions of the femoral neck except the posterior region. TbBMD contributed significantly to failure load in all regions of the femoral neck except the inferoanterior, superoposterior, and the posterior regions. CONCLUSION: Both cortical and trabecular bone make significant contributions to failure load in ex vivo measures of bone strength.


Subject(s)
Bone Density/physiology , Femur Neck/physiology , Hip Fractures/pathology , Absorptiometry, Photon , Adult , Aged , Aged, 80 and over , Cadaver , Female , Femur Neck/anatomy & histology , Femur Neck/diagnostic imaging , Hip Fractures/diagnostic imaging , Humans , Male , Middle Aged , Stress, Mechanical , Tomography, X-Ray Computed
12.
Australas Radiol ; 51(3): 257-9, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17504318

ABSTRACT

The purpose of this study was to compare the frequency of rotator cuff pathology versus labroligamentous pathology in patients younger than 40 years and to determine whether routine MR arthrography is justified in all patients in this age group, regardless of the clinical symptoms. The MR arthrography was carried out on 332 patients 40 years of age and younger. Two hundred and forty-three patients had clinical history of instability and possible labroligamentous pathology. Eighty-nine patients had no history or physical signs of instability and were referred for reasons other than instability, such as assessment for rotator cuff tear. In the 243 patients younger than 40 years with clinical history of potential labral pathology, 39% (95/243) showed a labral tear and 2.1% (5/243) had a full-thickness rotator cuff tendon tear. In the 89 patients with no history suggesting labral pathology, 19% (17/89) showed an unsuspected labral tear and 4.5% (4/89) had a full-thickness rotator cuff tear. These findings suggest that, regardless of the clinical indication for referral, patients aged 40 and less referred for shoulder MRI should be imaged using MR arthrography because of the significant risk that symptoms are related to unsuspected labral pathology.


Subject(s)
Arthrography/methods , Joint Instability/diagnosis , Ligaments, Articular/injuries , Magnetic Resonance Imaging/methods , Rotator Cuff Injuries , Shoulder Injuries , Adolescent , Adult , Contrast Media/administration & dosage , Diagnosis, Differential , Female , Gadolinium DTPA , Humans , Image Enhancement/methods , Iothalamate Meglumine , Ligaments, Articular/pathology , Male , Rotator Cuff/pathology , Sensitivity and Specificity , Shoulder Joint/pathology , Sodium Chloride/administration & dosage
13.
Psychol Med ; 35(2): 187-96, 2005 Feb.
Article in English | MEDLINE | ID: mdl-15841676

ABSTRACT

BACKGROUND: In a recent longitudinal study of first-episode schizophrenia patients, we found that while dysfunction of the right dorsolateral prefrontal cortex (DLPFC), right thalamus, left cerebellum and cingulate gyrus normalized with antipsychotic treatment and significant reduction in symptomatology, the left DLPFC, left thalamus, and right cerebellum remained disturbed. In the present study we investigated whether these abnormalities are also present in clinically stable, relatively well-functioning schizophrenia patients in comparison to control subjects during performance of the N-back working-memory task. METHOD: Twelve schizophrenia and 12 control subjects completed the study. The functional images collected during scanning were analyzed using a random-effects model in a restricted set of six regions of interest (ROIs). In addition, the exploratory search in the entire brain volume was performed. RESULTS: The ROI analyses revealed relative underactivation in the region of the left DLPFC and the right cerebellum, as well as overactivation in the left cerebellum. The exploratory whole-brain search exposed additional overactivation in the medial frontal, anterior cingulate, and left parietal cortices. CONCLUSIONS: The present study provides evidence of significant underactivations in stable schizophrenia patients in regions that we have previously observed to be dysfunctional in acutely psychotic and partially remitted patients, together with extensive overactivations in several regions that potentially reflect some compensatory mechanism or increased effort on the working-memory task.


Subject(s)
Cerebellum/pathology , Cerebellum/physiology , Memory , Prefrontal Cortex/pathology , Prefrontal Cortex/physiology , Schizophrenia/physiopathology , Schizophrenic Psychology , Adult , Antipsychotic Agents/pharmacology , Antipsychotic Agents/therapeutic use , Case-Control Studies , Cerebellum/drug effects , Female , Humans , Magnetic Resonance Imaging , Male , Prefrontal Cortex/drug effects
14.
Clin Radiol ; 59(4): 327-34, 2004 Apr.
Article in English | MEDLINE | ID: mdl-15041451

ABSTRACT

Lesions of the glenoid labrum and ligamentous structures commonly occur secondary to shoulder trauma and are a frequent cause of shoulder joint instability. Numerous eponyms, acronyms and subclassifications are used to describe the often confusing array of bony and labro-ligamentous abnormalities of the shoulder. This aim of this review is to illustrate the relevant features of these lesions and to provide a systematic and practical approach to imaging of the shoulder using MR arthrography.


Subject(s)
Joint Diseases/diagnosis , Magnetic Resonance Imaging , Shoulder Injuries , Humans , Joint Instability/diagnosis , Magnetic Resonance Imaging/methods
15.
Br J Sports Med ; 37(2): 149-53, 2003 Apr.
Article in English | MEDLINE | ID: mdl-12663358

ABSTRACT

OBJECTIVES: To (a) compare ultrasound (US; including grey scale and colour and power Doppler) and magnetic resonance imaging (MRI; with high resolution and fat saturation sequences) with a clinical yardstick in the evaluation of chronic Achilles tendinopathy, and (b) examine whether either imaging method predicted 12 and 24 month clinical outcome. METHODS: Forty five patients with symptoms in 57 Achilles tendons were diagnosed with tendinopathy by an experienced sports medicine doctor. All patients underwent US examination (12 MHz probe) with colour and power Doppler, and 25 consecutive patients also underwent MRI with high resolution T1 weighted and STIR sequences. RESULTS: US identified abnormal morphology in 37 of the 57 symptomatic tendons (65%) and normal morphology in 19 of 28 asymptomatic tendons (68%). Baseline US findings did not predict 12 month clinical outcome. The addition of colour and power Doppler did not improve the diagnostic performance of US. MRI identified abnormal morphology in 19 of 34 symptomatic tendons (56%) and normal morphology in 15 of 16 asymptomatic tendons (94%). Lesser grades of MR signal abnormality at baseline were associated with better clinical status at 12 month follow up. CONCLUSIONS: US and MRI show only moderate correlation with clinical assessment of chronic Achilles tendinopathy. Graded MRI appearance was associated with clinical outcome but US was not.


Subject(s)
Achilles Tendon/injuries , Achilles Tendon/diagnostic imaging , Adult , Aged , Female , Follow-Up Studies , Humans , Magnetic Resonance Imaging/methods , Male , Middle Aged , Prospective Studies , Ultrasonography, Doppler/methods
16.
Biol Psychiatry ; 50(9): 677-84, 2001 Nov 01.
Article in English | MEDLINE | ID: mdl-11704074

ABSTRACT

BACKGROUND: Psychopathy is a complex personality disorder of unknown etiology. Central to the disorder are anomalies or difficulties in affective processing. METHODS: Functional magnetic resonance imaging was used to elucidate the neurobiological correlates of these anomalies in criminal psychopaths during performance of an affective memory task. RESULTS: Compared with criminal nonpsychopaths and noncriminal control participants, criminal psychopaths showed significantly less affect-related activity in the amygdala/hippocampal formation, parahippocampal gyrus, ventral striatum, and in the anterior and posterior cingulate gyri. Psychopathic criminals also showed evidence of overactivation in the bilateral fronto-temporal cortex for processing affective stimuli. CONCLUSIONS: These data suggest that the affective abnormalities so often observed in psychopathic offenders may be linked to deficient or weakened input from limbic structures.


Subject(s)
Affect , Antisocial Personality Disorder/physiopathology , Crime , Limbic System/abnormalities , Limbic System/physiopathology , Magnetic Resonance Imaging , Adult , Amygdala/anatomy & histology , Amygdala/physiopathology , Frontal Lobe/anatomy & histology , Gyrus Cinguli/anatomy & histology , Gyrus Cinguli/physiopathology , Hippocampus/anatomy & histology , Hippocampus/physiopathology , Humans , Male , Pilot Projects , Temporal Lobe/anatomy & histology , Vocabulary
17.
Bone ; 29(4): 388-92, 2001 Oct.
Article in English | MEDLINE | ID: mdl-11595623

ABSTRACT

It is well established that forces applied to bone are the result of muscle contraction. However, data regarding the contribution of muscle cross-sectional area (because muscle area is proportional to muscle strength) to cortical bone area before puberty are controversial. We tested the hypothesis that muscle cross-sectional area is associated with total cortical bone area, and whether there is a region-specific relationship between these parameters in prepubertal and early pubertal girls. Seventeen healthy (9-11 years, Tanner stages I-II) white girls participated in the study. We measured bone loading characteristics (maximal ground reaction forces; GRFs) for a drop jump (50 cm) and side-to-side jump (over a 20-cm-high fence) on a multicomponent force platform. Muscle cross-sectional area and bone cortical area (square centimeters) of the proximal third of the left and right lower leg was measured with a 1.5 T magnetic resonance system using a quadrature head coil. The sequence was T(1) weighted, with spin-echo in transverse (tibial) planes and 3 mm sections with no gap (ten slices). The tibial cross-sectional areas were subdivided into three anatomical sectors (SI-SIII), with the tibial centroid as origin. SI extended from the medial tibial border to the most anterior edge, SII extended from the anterior edge laterally to the interosseous border, and SIII extended posteromedially from the interosseous border to the medial tibial border. The nonparametric bone and muscle volume correlations demonstrated that the total muscle cross-sectional area correlated significantly with the total cortical area in both legs (left leg: r(s) = 0.59, p = 0.020; right leg: r(s) = 0.57, p = 0.016). Significant correlations were also found between left and right muscle area and cortical area in SII (r(s) = 0.68, p = 0.003, 0.67, and 0.003, respectively). There was no significant association between the muscle area and cortical area in SI or SIII. In addition, there was a significant correlation between GRFs of the side-to-side jump and total cortical area (left leg: r = 0.75, p < 0.01; right leg: r = 0.78, p < 0.01). Thus, we found that muscle area was most highly associated with bone cortical area in SII, the anterolateral sector of the tibia, which emphasizes the specific interplay of muscles and bone in the lower limb. This relationship was present in a regional, site-specific fashion.


Subject(s)
Bone and Bones/anatomy & histology , Bone and Bones/physiology , Magnetic Resonance Imaging , Muscle, Skeletal/anatomy & histology , Muscle, Skeletal/physiology , Child , Female , Humans , Leg , Organ Size , Weight-Bearing
18.
Psychophysiology ; 38(1): 133-42, 2001 Jan.
Article in English | MEDLINE | ID: mdl-11321614

ABSTRACT

We used event-related functional magnetic resonance imaging (erfMRI) techniques to examine the cerebral sites involved with target detection and novelty processing of auditory stimuli. Consistent with the results from a recent erfMRI study in the visual modality, target processing was associated with activation bilaterally in the anterior superior temporal gyrus, inferior and middle frontal gyrus, inferior and superior parietal lobules, anterior and posterior cingulate, thalamus, caudate, and the amygdala/hippocampal complex. Analyses of the novel stimuli revealed activation bilaterally in the inferior frontal gyrus, insula, inferior parietal lobule, and in the inferior, middle, and superior temporal gyri. These data suggest that the scalp recorded event-related potentials (e.g., N2 and P3) elicited during similar tasks reflect an ensemble of neural generators located in spatially remote cortical areas.


Subject(s)
Auditory Perception/physiology , Sound Localization/physiology , Acoustic Stimulation , Adult , Evoked Potentials/physiology , Female , Humans , Magnetic Resonance Imaging , Male
19.
Radiology ; 213(3): 705-8, 1999 Dec.
Article in English | MEDLINE | ID: mdl-10580942

ABSTRACT

PURPOSE: To assess the magnetic resonance (MR) imaging appearance of the successfully repaired rotator cuff in an asymptomatic population. MATERIALS AND METHODS: Fifteen subjects who had undergone clinically successful rotator cuff repair were included in the study. All underwent functional testing of the affected shoulder and had good to excellent scores on the Constant scale. Standard MR imaging sequences were performed at 1.5 T, including oblique coronal fast spin-echo T2-weighted MR imaging with fat saturation. RESULTS: Three (10%) of 30 supraspinatus and infraspinatus tendons had normal signal intensity, and 16 (53%) had mildly increased signal intensity on fast spin-echo T2-weighted fat-saturated images, compatible with tendonitis or tendinosis. Three partial and four complete tears of the supraspinatus tendon and two partial and two complete tears of the infraspinatus tendon were seen. Other findings included subacromial-subdeltoid effusion (10 subjects), joint effusions (five subjects), and bone marrow edema (six subjects). CONCLUSION: Postoperative signal intensity changes consistent with tendonitis or tendinosis were common, and clinically "silent" partial and complete rotator cuff tears were seen. Such postoperative MR imaging findings should be interpreted with caution, and meticulous correlation with symptoms and clinical results is recommended.


Subject(s)
Magnetic Resonance Imaging , Postoperative Complications/diagnosis , Rotator Cuff/surgery , Tendinopathy/diagnosis , Tendon Injuries/surgery , Aged , Bone Marrow/pathology , Edema/diagnosis , Female , Humans , Male , Middle Aged , Rotator Cuff/pathology , Rotator Cuff Injuries , Shoulder Joint/pathology , Tendon Injuries/diagnosis
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