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1.
Allergol Immunopathol (Madr) ; 48(4): 409-413, 2020.
Article in English | MEDLINE | ID: mdl-31831191

ABSTRACT

CD40 ligand deficiency (CD40L), currently classified as an inborn error of immunity affecting cellular and humoral immunity, prevalently emerges in boys within the first two years of life. It manifests itself as a decrease in serum IgG, IgA and IgE, with normal or high IgM, defects in T cell proliferation, and decrease in soluble CD40L. These accompany sinopulmonary and/or gastrointestinal infections, and there may be infections caused by pyogenic bacteria, opportunistic infections, autoimmune diseases, and neoplasms. Mild and moderate cases of this deficiency may respond well to prophylactic antibiotic therapy or to human immunoglobulin replacement therapy, in addition to the early treatment of infections. Severe cases can be treated with hematopoietic stem cell transplantation, which allows the healing of such patients, rather than sequelae and a poor progression. Thus, its differential diagnosis with other inborn errors of immunity is essential, especially CD40 deficiency and variable common immunodeficiency; the reason why we have proposed the present literature review.


Subject(s)
CD40 Ligand/deficiency , Hyper-IgM Immunodeficiency Syndrome, Type 1/diagnosis , Hyper-IgM Immunodeficiency Syndrome, Type 1/therapy , Humans , Hyper-IgM Immunodeficiency Syndrome, Type 1/immunology , Male
2.
Allergol Immunopathol (Madr) ; 44(4): 286-91, 2016.
Article in English | MEDLINE | ID: mdl-27083494

ABSTRACT

BACKGROUND: Chronic urticaria can be the initial clinical presentation of a number of different diseases. The objective of the present study was to report the associated diseases during a ten-year clinical-laboratory follow-up in patients with an initial diagnosis of chronic spontaneous urticaria (CSU) of unknown cause. METHODS: A prospective, longitudinal cohort study with a ten-year clinical-laboratory follow-up was conducted. Patients with a history of urticarial plaques of over six weeks presenting as the only clinical symptom were selected. Individuals with other clinical conditions, urticaria of known causes or chronic physical urticaria were excluded. The following tests were initially performed: haemogram, urine type I, stool parasite exam and sedimentation rate. The following exams were ordered during follow-up: PPD; urine culture; serology tests; antithyroid and antinuclear antibodies, rheumatoid factor, lupus anticoagulant; thyroid hormones; serum immunoglobulin; paranasal sinus and thorax radiographs; testing for BK and Helicobacter pylori; and prick tests. RESULTS: Infections were diagnosed in 29% of patients (syphilis, parasitosis, H. pylori, urinary infection, tuberculosis, hepatitis B and C); autoimmune diseases in 21% (thyroiditis, rheumatoid arthritis and antiphospholipid antibody syndrome); primary immunodeficiencies in 4% (IgA and IgG2 deficiencies); and chronic myeloid leukaemia in 1%. At ten-years of follow-up, the urticaria diagnosis was CSU of unknown cause in 45% of the cases. CONCLUSION: This ten-year clinical-laboratory follow-up of 100 individuals with chronic urticaria as the initial diagnosis revealed the presence of associated diseases in over half of the cases. The most prevalent diseases were infections and autoimmune diseases besides primary immunodeficiencies and blood diseases.


Subject(s)
Autoimmune Diseases/complications , Communicable Diseases/complications , Dysgammaglobulinemia/complications , Urticaria , Adult , Autoimmune Diseases/diagnosis , Autoimmune Diseases/epidemiology , Chronic Disease , Communicable Diseases/diagnosis , Communicable Diseases/epidemiology , Dysgammaglobulinemia/diagnosis , Dysgammaglobulinemia/epidemiology , Female , Follow-Up Studies , Humans , Longitudinal Studies , Male , Prevalence , Prospective Studies , Skin Tests , Urticaria/diagnosis , Urticaria/epidemiology , Urticaria/immunology
3.
Ren Fail ; 32(4): 464-8, 2010 May.
Article in English | MEDLINE | ID: mdl-20446785

ABSTRACT

BACKGROUND: Cryoglobulinemia is frequent in renal transplant patients. The mononuclear and polymorphonuclear neutrophil (PMN) phagocytic systems are important for the clearance of cryoglobulin immune complexes. There might be a reduced phagocytic activity in transplant patients with cryoglobulinemia (CRYO+). METHODS: We studied the phagocytic activity by PMNs, in the presence of immune complexes in renal transplant patients, with or without hepatitis C virus (HCV) infection. Thirty-seven patients subjected to kidney transplant were evaluated, and for the control group, healthy blood donors were chosen. The presence of cryoprecipitate was evaluated, as well as HCV infection, phagocytic activity by neutrophils during the ingestion and digestion phase. RESULTS: The presence of cryoprecipitate was detected in 75.7% of the patients, 39.28% of which had HCV infection. IgG, IgM, IgA, and C3 and C4 complement components were identified in the cryoprecipitate. There was a reduction in the ingestion phase of phagocytosis by PMNs in renal transplant CRYO+ though the digestion phase was preserved. CONCLUSION: We concluded that there was a decreased PMN activity in transplanted patients presenting cryoglobulinemia.


Subject(s)
Cryoglobulinemia/immunology , Kidney Transplantation/immunology , Phagocytosis/immunology , Adolescent , Adult , Aged , Brazil/epidemiology , Case-Control Studies , Cryoglobulinemia/epidemiology , Cryoglobulins/immunology , Female , Hepatitis C/epidemiology , Hepatitis C/immunology , Humans , Male , Middle Aged , Prevalence
4.
Allergol. immunopatol ; 37(6): 302-308, nov.-dic. 2009. tab
Article in English | IBECS | ID: ibc-77016

ABSTRACT

Background: Patients with atopic dermatitis frequently present recurrent infections by pyogenic bacteria or by intracellular microorganisms, suggesting an immune disorder. Objective: Laboratorial investigation of phagocyte activity and chemotactic response by neutrophilic polymorphonuclear and mononuclear phagocytes in the peripheral blood of patients with atopic dermatitis from moderate to severe. Methods: Through a transversal study, patients with atopic dermatitis from moderate to severe were selected. The neutrophilic and mononuclear phagocytes were separated and the phagocytic ingestion of zymosan particles was analysed, in addition to migration distance to the bacterial lipopolysaccharide chemotactic factor, comparing the results to the values obtained from healthy individuals within the same age group. Results: Nineteen patients were selected, 11 female and 8 male. The mean age was 6.47 years (±4.65). Among the 19 patients studied, 14 (73.68%) presented a reduction in the neutrophilic and mononuclear phagocyte activity, with two (1.53%) patients presenting a reduction in the activity of both phagocytes. Conclusion: Our results demonstrated a reduction in chemotactic response and phagocytic activity by neutrophilic and/or mononuclear phagocytes in the majority of patients with atopic dermatitis from moderate to severe. Our results were coherent with the clinical data concerning the higher incidence of infections by pyogenic bacteria and fungi in patients with atopic dermatitis, which are microorganisms that require defence by the phagocytes researched in the present study (AU)


Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Dermatitis, Atopic , Dermatitis, Atopic/therapy , Phagocytes , Neutrophils , Leukocytes, Mononuclear , Chemotaxis , Phagocytosis , Cross-Sectional Studies , Case Reports
5.
Allergol Immunopathol (Madr) ; 37(6): 302-8, 2009.
Article in English | MEDLINE | ID: mdl-19853354

ABSTRACT

BACKGROUND: Patients with atopic dermatitis frequently present recurrent infections by pyogenic bacteria or by intracellular microorganisms, suggesting an immune disorder. OBJECTIVE: Laboratorial investigation of phagocyte activity and chemotactic response by neutrophilic polymorphonuclear and mononuclear phagocytes in the peripheral blood of patients with atopic dermatitis from moderate to severe. METHODS: Through a transversal study, patients with atopic dermatitis from moderate to severe were selected. The neutrophilic and mononuclear phagocytes were separated and the phagocytic ingestion of zymosan particles was analysed, in addition to migration distance to the bacterial lipopolysaccharide chemotactic factor, comparing the results to the values obtained from healthy individuals within the same age group. RESULTS: Nineteen patients were selected, 11 female and 8 male. The mean age was 6.47 years (+/-4.65). Among the 19 patients studied, 14 (73.68%) presented a reduction in the neutrophilic and mononuclear phagocyte activity, with two (1.53%) patients presenting a reduction in the activity of both phagocytes. CONCLUSION: Our results demonstrated a reduction in chemotactic response and phagocytic activity by neutrophilic and/or mononuclear phagocytes in the majority of patients with atopic dermatitis from moderate to severe. Our results were coherent with the clinical data concerning the higher incidence of infections by pyogenic bacteria and fungi in patients with atopic dermatitis, which are microorganisms that require defence by the phagocytes researched in the present study.


Subject(s)
Chemotaxis, Leukocyte/immunology , Dermatitis, Atopic/immunology , Phagocytes/immunology , Phagocytosis/immunology , Adolescent , Adult , Age of Onset , Allergens/immunology , Bacterial Infections/complications , Bacterial Infections/immunology , Child , Child, Preschool , Dermatitis, Atopic/complications , Dermatitis, Atopic/diagnosis , Dermatitis, Atopic/epidemiology , Female , Humans , Hypersensitivity/complications , Immunoglobulin E/blood , Immunoglobulin E/immunology , Leukocyte Count , Lipopolysaccharides/immunology , Macrophages/cytology , Macrophages/immunology , Male , Mycoses/complications , Mycoses/immunology , Neutrophils/cytology , Neutrophils/immunology , Phagocytes/cytology , Skin Tests , Young Adult , Zymosan/immunology
6.
Allergol Immunopathol (Madr) ; 34(4): 136-40, 2006.
Article in English | MEDLINE | ID: mdl-16854345

ABSTRACT

UNLABELLED: The aim of this study was to evaluate immune function in acute stress in medical students before academic examinations. Twenty-five medical students were selected because they presented intense acute stress, evaluated by the presence of the following classic signs: cold hands, intense sudoresis in the extremities, generalized sudoresis, paleness, tachycardia, confused reasoning, nervous irritability, diarrhea, and sleep disorders in the hours preceding the examination (agitated sleep, insomnia). METHODS: Immediately before the examination, peripheral blood was collected from the 25 students presenting acute stress to analyze T and B cells, CD4+ and CD8+ cells, immunoglobulins, and C3 and C4 complement components, as well as phagocytic activity in neutrophils and monocytes. These investigations were repeated in the same students in situations free of acute stress. The results of the two samples collected from each student were compared. RESULTS: The means and standard deviations showed no significant differences for any of the parameters analyzed (p> or =0.01). CONCLUSION: We conclude that acute stress did not cause changes in the lymphocyte subpopulations, phagocytic activity of neutrophils and monocytes, serum immunoglobulins, or C3 and C4 complement components in students participating in the present study. In conditions of basal chronic stress, acute stress may cause alterations in immune function.


Subject(s)
Stress, Psychological/immunology , Acute Disease , Adult , CD4-Positive T-Lymphocytes/immunology , CD8-Positive T-Lymphocytes/immunology , Complement C3/analysis , Complement C4/analysis , Educational Measurement , Female , Humans , Immunoglobulins/analysis , Lymphocyte Count , Male , Monocytes/immunology , Neutrophils/immunology , Phagocytosis , Stress, Psychological/blood , Students/psychology , Test Anxiety Scale
7.
Transplant Proc ; 37(10): 4273-5, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16387095

ABSTRACT

The aim of this study was to assess the presence of cryoglobulins, the constitution of the cryoprecipitate, as well as the possible etiology and clinical features in kidney transplant recipients. We excluded patients with clinical or laboratory evidence of autoimmune, liver or neoplasm disease, infections, blood transfusions or immunizations in the previous 3 months. Detection of cryoglobulins was obtained from the peripheral venous blood. In cases of cryoprecipitate formation it was analyzed using anti-IgG, anti-IgM, anti-IgA, anti-C3, and anti-C4 antibodies. The hepatitis C virus (HCV) was detected by the polymerase chain reaction. Thirty-nine patients were selected, of whom 23 were men and the overall mean age was 40.6 +/- 12.7 years. Cryoprecipitate was detected in 74.4% (29/39) patients. Among patients with or without cryoprecipitate formation, the serum creatinine values, the percentage of patients with proteinuria, and the posttransplantation times were similar. In patients with cryoglobulins, 37.9% (11/29) were HCV positive. The etiology was not determined for the other patients. The IgG, IgM, and IgA immunoglobulins and the complement fractions C3 and C4 were found in the cryoprecipitate. Their compositions were similar among patients with or without HCV. Few clinical features were associated with the presence of cryoglobulins, including deep venous thrombosis, cutaneous purpura and peripheral neuropathy. In conclusion, cryoglobulinemia was prevalent in kidney transplant recipients, but appeared to not affect graft function. HCV infection was the most frequently associated etiology and clinical features were infrequent.


Subject(s)
Cryoglobulinemia/blood , Cryoglobulins/analysis , Kidney Transplantation/adverse effects , Adult , Complement System Proteins/immunology , Female , Follow-Up Studies , Hepatitis B/blood , Hepatitis B/complications , Humans , Immunoglobulin A/blood , Immunoglobulin A/immunology , Immunoglobulin G/blood , Immunoglobulin G/immunology , Immunoglobulin M/blood , Immunoglobulin M/immunology , Kidney Failure, Chronic/etiology , Kidney Failure, Chronic/surgery , Kidney Transplantation/physiology , Male , Middle Aged , Postoperative Complications/blood , Time Factors
8.
Allergol Immunopathol (Madr) ; 32(2): 89-91, 2004.
Article in English | MEDLINE | ID: mdl-15087097

ABSTRACT

We describe a patient with common variable immunodeficiency who three times presented an anaphylactic reaction after intravenous immunoglobulin administration. These reactions were attributed to the total absence of IgG 2, 3 and 4.


Subject(s)
Anaphylaxis/etiology , Common Variable Immunodeficiency/therapy , Immunoglobulins, Intravenous/adverse effects , Adolescent , Common Variable Immunodeficiency/diagnosis , Common Variable Immunodeficiency/immunology , Female , Humans , Immunoglobulin G/classification , Immunoglobulin G/immunology , Immunoglobulins, Intravenous/immunology , Immunoglobulins, Intravenous/therapeutic use , Pneumonia/etiology , Recurrence
9.
Allergol Immunopathol (Madr) ; 31(2): 83-6, 2003.
Article in English | MEDLINE | ID: mdl-12646123

ABSTRACT

UNLABELLED: Infections and malnutrition remain the main causes of infant mortality in developing countries. In protein-calorie malnutrition, immunologic responses are affected, which often facilitates infections. However, the presence of asthma and allergic rhinitis are not commonly recognized in malnourished individuals. The aim of this study was to evaluate serum IgE values in children with primary moderate protein-calorie malnutrition. METHODS: The level of IgE in peripheral blood of 18 children between 2 and 4 old with moderate protein-calorie malnutrition and without associated parasitic infestation was compared with that of 15 well nourished children of similar age. IgE serum levels were measured by an immunoenzymatic method. RESULTS: The median level of serum IgE in malnourished children was 69.30 ng/ml while the control group showed a mean level of 95.97 ng/ml. This difference was significant (p < 0.01). CONCLUSION: Malnourished children show decreased serum IgE levels. This might be one of the adaptive mechanisms of malnutrition employed in an attempt to use energy and protein reserves for growth and other functions. Our results are coherent with the decrease in IgE mediated reactions in malnourished patients.


Subject(s)
Dysgammaglobulinemia/etiology , Immunoglobulin E/deficiency , Protein-Energy Malnutrition/complications , Brazil , Child, Preschool , Female , Humans , Immunoglobulin E/blood , Male , Protein-Energy Malnutrition/blood , Protein-Energy Malnutrition/immunology
10.
Allergol Immunopathol (Madr) ; 30(5): 263-6, 2002.
Article in English | MEDLINE | ID: mdl-12396960

ABSTRACT

Five patients with atopic dermatitis, three males and two females, aged 2 to 17 years, had positive reactions to air allergens (Dermatophagoides pteronyssinus and/or farinae). All the patients suffered from severe recurrent dermatophytosis that responded poorly to antifungal treatment. The results of immunologic evaluation by laboratory tests were normal, except for a decrease in the ingestion phase by mononuclear phagocytes. After diagnosis of immunodeficiency, ketoconazole shampoo was used prophylactically and at the very first signs of recurrence of dermatophytosis, systemic antifungal treatment was started, without concurrent use of macrolides and with monitoring of hepatic function. The fungal infections responded well to this treatment and the patients' quality of life markedly improved.


Subject(s)
Dermatitis, Atopic/immunology , Dermatomycoses/immunology , Monocytes/pathology , Phagocytosis , Administration, Cutaneous , Administration, Oral , Adolescent , Allergens/adverse effects , Animals , Antifungal Agents/therapeutic use , Candidiasis, Cutaneous/complications , Candidiasis, Cutaneous/drug therapy , Candidiasis, Cutaneous/immunology , Child , Child, Preschool , Dermatitis, Atopic/complications , Dermatitis, Atopic/pathology , Dermatomycoses/complications , Dermatomycoses/drug therapy , Dermatomycoses/pathology , Disease Susceptibility , Facial Dermatoses/complications , Facial Dermatoses/immunology , Facial Dermatoses/pathology , Female , Humans , Infant , Ketoconazole/therapeutic use , Male , Pyroglyphidae/immunology , Tinea/complications , Tinea/drug therapy , Tinea/immunology
11.
Rev. Assoc. Med. Bras. (1992, Impr.) ; 45(2): 147-51, abr.-jun. 1999. tab, graf
Article in Portuguese | LILACS | ID: lil-233425

ABSTRACT

Objetivo. Avaliar a etapa de ingestao da fagocitose e do metabolismo oxidativo de neutrófilos em crianças portadoras de desnutriçao moderada. Métodos. Foi analisado o sangue periférico de vinte e duas crianças portadoras de desnutriçao moderada, sem infecçao, comparando-se os resultados aos de vinte crianças eutróficas da mesma faixa etária (2 a 5 anos de idade). A ingestao fagocitária por neutrófilos foi avaliada através da ingestao de partículas de zimosan e o metabolismo oxidativo avaliado pela reduçao do nitro blue tetrazolium entre um número fixo de 200 neutrófilos. Resultados. As médias aritméticas da ingestao por neutrófilos de partículas de zimosan, zimosan incubado com soro homólogo e zimosan incubado com soro autólogo foram 18, 41 e 46 em desnutridos e 20, 57 e 63 em eutróficos. A reduçao espontânea e estimulada de nitro blue tetrazolium foi de 6 e 11 em desnutriçao e 12 e 17 em eutróficos. Conclusao. Concluiu-se haver uma diminuiçao da etapa da ingestao e do metabolismo oxidativo de neutrófilos nos pacientes estudados portadores de desnutriçao moderada.


Subject(s)
Humans , Child, Preschool , Infant , Phagocytosis , Neutrophils/metabolism , Nutrition Disorders/metabolism , Protein-Energy Malnutrition/blood , Neutrophils/chemistry , Nutrition Disorders/immunology , Nutrition Disorders/blood
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