PARS, a system combining semantic technologies with multiple criteria decision aiding for supporting antibiotic prescriptions.

OBJECTIVE: Motivated by the well documented worldwide spread of adverse drug events, as well as the increased danger of antibiotic resistance (caused mainly by inappropriate prescribing and overuse), we propose a novel recommendation system for antibiotic prescription (PARS). METHOD: Our approach is based on the combination of semantic technologies with MCDA (Multiple Criteria Decision Aiding) that allowed us to build a two level decision support model. Given a specific domain, the approach assesses the adequacy of an alternative/action (prescription of antibiotic) for a specific subject (patient) with an issue (bacterial infection) in a given context (medical). The goal of the first level of the decision support model is to select the set of alternatives which have the potential to be suitable. Then the second level sorts the alternatives into categories according to their adequacy using an MCDA sorting method (MR-Sort with Veto) and a structured set of description logic queries. RESULTS: We applied this approach in the domain of antibiotic prescriptions, working closely with the EpiCura Hospital Center (BE). Its performance was compared to the EpiCura recommendation guidelines which are currently in use. The results showed that the proposed system is more consistent in its recommendations when compared with the static EpiCura guidelines. Moreover, with PARS the antibiotic prescribing workflow becomes more flexible. PARS allows the user (physician) to update incrementally and dynamically a patient's profile with more information, or to input knowledge modifications that accommodate the decision context (like the introduction of new side effects and antibiotics, the development of germs that are resistant, etc). At the end of our evaluation, we detail a number of limitations of the current version of PARS and discuss future perspectives.

Towards interpretable machine learning models for diagnosis aid: A case study on attention deficit/hyperactivity disorder.

Attention Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that has heavy consequences on a child's wellbeing, especially in the academic, psychological and relational planes. The current evaluation of the disorder is supported by clinical assessment and written tests. A definitive diagnosis is usually made based on the DSM-V criteria. There is a lot of ongoing research on ADHD, in order to determine the neurophysiological basis of the disorder and to reach a more objective diagnosis. The advent of Machine Learning (ML) opens up promising prospects for the development of systems able to predict a diagnosis from phenotypic and neuroimaging data. This was the reason why the ADHD-200 contest was launched a few years ago. Based on the publicly available ADHD-200 collection, participants were challenged to predict ADHD with the best possible predictive accuracy. In the present work, we propose instead a ML methodology which primarily places importance on the explanatory power of a model. Such an approach is intended to achieve a fair trade-off between the needs of performance and interpretability expected from medical diagnosis aid systems. We applied our methodology on a data sample extracted from the ADHD-200 collection, through the development of decision trees which are valued for their readability. Our analysis indicates the relevance of the limbic system for the diagnosis of the disorder. Moreover, while providing explanations that make sense, the resulting decision tree performs favorably given the recent results reported in the literature.

Reducing the Toxicity Risk in Antibiotic Prescriptions by Combining Ontologies with a Multiple Criteria Decision Model.

We consider the risk of adverse drug events caused by antibiotic prescriptions. Antibiotics are the second most common cause of drug related adverse events and one of the most common classes of drugs associated with medical malpractice claims. To cope with this serious issue, physicians rely on guidelines, especially in the context of hospital prescriptions. Unfortunately such guidelines do not offer sufficient support to solve the problem of adverse events. To cope with these issues our work proposes a clinical decision support system based on expert medical knowledge, which combines semantic technologies with multiple criteria decision models. Our model links and assesses the adequacy of each treatment through the toxicity risk of side effects, in order to provide and explain to physicians a sorted list of possible antibiotics. We illustrate our approach through carefully selected case studies in collaboration with the EpiCURA Hospital Center in Belgium.