[Effect of the stable prostacyclin analog Iloprost on enzyme release during extracorporeal kidney perfusion]. / Die Wirkung des stabilen Prostazyklin-Analogons Iloprost auf die Enzymfreisetzung während der extrakorporalen Nierenperfusion.

The influence of the stable prostacyclin-analogue Iloprost (Fa. Schering, Berlin) in the enzyme release from extracorporalic perfused kidneys was tested in an experimental investigation. The mechanic hypothermic perfusion was carried out on four different conditions. The estimation of specially cytosolic, lysosomal, and membrane-associated enzymes in the perfusat of the kidneys showed less activities in the Iloprost-protected kidneys. The results after the replantation of the kidneys support the interpretation of the enzyme determinations.

[The improvement of the tolerance of the kidney for ischemia with the prostacyclin analog iloprost]. / Untersuchungen zur Verbesserung der Ischämietoleranz der Niere mit dem Prostazyklinanalogen Iloprost.

Operative trauma, ischemia, release of catecholamines and thermal stimuli in consequence of harvesting, preservation and transplantation deteriorate the renal capillary circulation. By crossing of tolerance limits arises an irreversible transplant damage. The conditions of our examinations were placed in this field. By pre- and postischemic application of Iloprost was demonstrable an improvement of the ischemic tolerance of the kidney. Correction of renal hemodynamics, antiplatelet action and cytoprotection are the reasons of the protective influence of Iloprost in our opinion.

[Staging of metastasized bladder cancer using parietocystotomography]. / Staging fortgeschrittener Harnblasenkarzinome durch Parietozystotomographie.

To date no diagnostic procedure has been able accurately to stage carcinomas of the urinary bladder. Parietocystotomography by means of instillation of air and nitrous oxide was used in an attempt to distinguish between the tumour infiltration stages T3A , T3B and T4 and to depict them radiologically. Using this method it is possible to achieve a high degree of concurrence between radiological findings and the pathological-anatomical substrate. The methods, results achieved and the limits of the procedure are demonstrated.

[The clinical problem of living with one kidney]. / Zum klinischen Problem der Einnierigkeit.

The chance on a complete compensation of the residual kidney is the larger the earlier the nephrectomy as performed. Infections of the urinary tract, pyelonephritis, affection with calculi and functional disturbances are the most frequent diseases of the residual kidney particularly then, when the contralateral organ was also removed for these reasons. Specific tuberculous inflammations and tumorous affection of the residual kidney rarely appeared.

[Clinical aspects and treatment of acute kidney failure]. / Klinik und Behandlung des akuten Nierenversagens.

It is reported on haemodialyses which were carried out in the period from 1959--1978 in 157 patients with acute renal failure. Here in 25 cases developed exogenic intoxications. The surgically conditioned cases of acute renal failure were subdivided into 7 groups according to the basic diseases. The lethality of about 47% significantly differs in the individual surgical noxes from the data of literature. It is dealth with the general principles of treatment in these acute pictures of disease, which 1. consist in a basic treatment--maintenance of vital functions--and 2. in an elimination of the damaging noxe--elimination of the exogenic poison and removal of the surgical basic diseases and tiding over of the temporary deficiency of the renal function. Of the deceased patients about 16% came ad exitum in uraemia. The others died of the basic disease which could not be controlled. Thus the prognosis depends on the prognosis of the basic disease. In the intoxications the prognosis mainly depends on the dialysability and the quantity of the poison as well as on the time interval between intake of poison and beginning of the treatment.

[Vascular connections for hemodialysis with reference to thromboses and infections]. / Gefässanschlüsse für die Hämodialyse unter besonderer Berücksichtigung von Thrombosen und Infektionen.

A survey of the at present possible vascular accesses and their valency for acute and chronic haemodialyses depending on age and body weight is followed by a comparison of the two most essential possibilities of access Scribner-shunt and fistula Brescia-Cimino. Thei main complications thombosis and infection are discussed and therapeutic directives are shown.

[Kidney transplant center in Halle: report on the current status, the organization of cadaveric kidneys and the results of transplants]. / Nierentransplantationszentrum Halle: Bericht über den aktuellen Stand, Organisation der Leichennierenspende und Ergebnisse der Transplantation.

After the historical description of transplantations in Europe since 1966 the essential new facts and constant data in donnor conditioning, transplantation and after-treatment are discussed on the basis of special literature. 63 own courses are evaluated with complications.

Liquid helium cryopump and reliable opening device for a balloon-borne mass spectrometer.

The design, technical characteristics, and test and flight results of a liquid helium cryopump and an opening device operating on board a balloon-borne mass spectrometer combining a cryopump and a quadrupole mass filter are reported. The gas inlet of this mass spectrometer is opened through a simple and reliable remote-controlled system, which is also described.

[Progressive multifocal leukoencephalopathy as a complication of immunosuppression in kidney transplantation]. / Die progressive multifokale Leukenzephalopathie als Komplikation der Immunsuppression der Nierentransplantierten.

The progressive multifocal leukencephalopathy is mostly observed as paraneoplastic complication of malignant lymphoproliferative systemic diseases. It may develop also under the influence of a long-term immunosuppressive therapy, as it is necessary in the rejection treatment of recipients or organ transplantations. It is reported on a 44-year-old man in whom a progressive multifocal leukencephalopathy with exitus letalis developed 6 months after a kidney transplantation and following immunosuppressive therapy. In the oligodendroglia of the marginal region of leukodystrophic foci in the centrum semiovale of the right cerebral hemisphere by means of electron microscopy paracrystalline situated virions of the type Papova were proved in most cases.