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1.
Am J Med ; 76(1): 155-8, 1984 Jan.
Article in English | MEDLINE | ID: mdl-6691354

ABSTRACT

The association of sudden unexpected death with coronary artery anomalies has been limited to cases of anomalous origin of the left main coronary artery, either from the right sinus of Valsalva or from the main pulmonary artery. In contrast, anomalies involving the origin of the right coronary artery have been considered to be benign. Postmortem examination in a patient who died suddenly at 23 years of age disclosed that the right coronary artery originated anomalously from the left sinus of Valsalva. The findings in this patient: (1) constitute the first necropsy documentation of premature sudden unexpected death in a patient whose sole pathologic abnormality was anomalous origin of the right coronary artery; (2) have important implications regarding previously proposed mechanisms of sudden death due to anomalous origin of the left main coronary artery; and (3) support recent suggestions that markedly acute angulation of either coronary artery, even when located in the appropriate sinus of Valsalva, may predispose to sudden unexpected death.


Subject(s)
Coronary Vessel Anomalies/pathology , Death, Sudden/etiology , Sinus of Valsalva/abnormalities , Adult , Death, Sudden/pathology , Humans , Male
3.
Am J Cardiol ; 51(5): 689-93, 1983 Mar 01.
Article in English | MEDLINE | ID: mdl-6219568

ABSTRACT

The coronary arteries from 70 consecutive patients in whom percutaneous transluminal angioplasty (PTA) had not been performed during life were examined at necropsy for findings that have been previously described in patients or animals treated with PTA. In 33 (49%) of the 70 patients, 1 or more findings identical to those observed in necropsy studies of PTA-treated arteries were observed: "plaque fractures" in 31 (44%), "dissection clefts" in 26 (33%), and extensive medial thinning in 40 (57%). Observations in these 70 patients indicate that findings previously described in PTA-treated patients cannot necessarily be assumed to represent the results of PTA. The fact that improved vessel patency may be seen in the absence as well as the presence of such lesions precludes firm assurance that such lesions are the sole basis for successful angioplasty.


Subject(s)
Angioplasty, Balloon , Coronary Disease/pathology , Coronary Vessels/pathology , Coronary Disease/therapy , Humans
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