ABSTRACT
BACKGROUND: Basal cell carcinoma (BCC) is the most common skin cancer in the white population. Nonsurgical treatments are first-line alternatives in superficial BCC (sBCC); therefore, differentiating between sBCC and non-sBCC is of major relevance for the clinician. Scraping cytology possesses several advantages, such as an earlier diagnosis and scarring absence, in comparison to a biopsy. Nevertheless, previous studies reported difficulties in differentiating the different BCC subtypes. The objective of this study was to determine the capability and accuracy of scraping cytology to differentiate between sBCC and non-sBCC. METHODS: In this retrospective study, cytological samples of histologically confirmed BCC were examined. Select cytological features were correlated to BCC subtypes (sBCC or non-sBCC). RESULTS: A total of 84 BCC samples were included (29 sBCC; 55 non-sBCC). An inverse correlation between the diagnosis of sBCC and the presence of mucin, dehiscence, and grade of atypia in the basal cells was observed. The presence of medium and large basal cell clusters correlated directly to a sBCC diagnosis. The presence of clear cells is strongly associated with sBCC. Therefore, Conclusion: Scraping cytology is reliable in differentiating sBCC from other BCC subtypes.
ABSTRACT
Reflectance confocal microscopy (RCM) is a noninvasive imaging technique that allows visualization of the epidermis and papillary dermis with cellular-level resolution. Granulomatous reactions such as sarcoidosis could be assessed using RCM. The identification of bright beaded-like structures that could correspond to reticulin fibers overlying granulomas, in association with dermoscopy, may be a very useful approach in the diagnosis of sarcoidosis and for the differentiation of this granulomatous entity with superficial cutaneous metastasis.
Subject(s)
Microscopy, Confocal/methods , Sarcoidosis/diagnostic imaging , Skin Diseases/diagnostic imaging , Aged , Biopsy , Dermoscopy/methods , Female , Granuloma/diagnostic imaging , Granuloma/pathology , Humans , Sarcoidosis/pathology , Skin Diseases/pathologyABSTRACT
Abstract: Reflectance confocal microscopy (RCM) is a noninvasive imaging technique that allows visualization of the epidermis and papillary dermis with cellular-level resolution. Granulomatous reactions such as sarcoidosis could be assessed using RCM. The identification of bright beaded-like structures that could correspond to reticulin fibers overlying granulomas, in association with dermoscopy, may be a very useful approach in the diagnosis of sarcoidosis and for the differentiation of this granulomatous entity with superficial cutaneous metastasis.
Subject(s)
Humans , Female , Aged , Sarcoidosis/diagnostic imaging , Skin Diseases/diagnostic imaging , Microscopy, Confocal/methods , Sarcoidosis/pathology , Skin Diseases/pathology , Biopsy , Dermoscopy/methods , Granuloma/pathology , Granuloma/diagnostic imagingSubject(s)
Adenoma/diagnostic imaging , Breast Neoplasms/diagnostic imaging , Cryosurgery/methods , Nipples/diagnostic imaging , Adenoma/pathology , Adenoma/surgery , Adult , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Female , Humans , Nipples/pathology , Nipples/surgery , Ultrasonography, MammaryABSTRACT
Cutaneous leiomyosarcomas are uncommon malignant tumors of smooth muscle. We report herein two cases of cutaneous leiomyosarcoma, one of dermal and other of subcutaneous vascular origin, confirmed by histology and immunohistochemistry. Both cases were treated with wide surgical excision, one with local recurrence. No metastases were detected at follow-up. Leiomyosarcomas should be considered in lesions with histologic features of spindle cell malignancy. It is necessary in most of the cases a histological differentiation with specific immunohistochemical markers. The treatment of choice is radical excision with wide margins, achieving satisfactory results.
