ABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Attention Deficit and Disruptive Behavior Disorders/diagnosis , Anxiety Disorders/complications , Nasal Septum/diagnostic imaging , Biopsy , Nasal Septal Perforation/etiology , Dermatitis/drug therapy , Attention Deficit and Disruptive Behavior Disorders/psychology , Nasal Septum/pathology , Nasal Septum/surgery , Diagnosis, Differential , Combined Modality Therapy , Nasal Septal Perforation/diagnostic imaging , Nasal Septal Perforation/therapy , Aripiprazole/administration & dosageABSTRACT
No disponible
No disponible
Subject(s)
Humans , Female , Adult , Syringoma/complications , Syringoma/diagnosis , Syringoma/therapy , Lasers/therapeutic use , Immunohistochemistry/methods , Adenoma, Sweat Gland/complications , Adenoma, Sweat Gland/diagnosis , Diagnosis, Differential , Dermis/pathology , Stromal Cells/pathology , Trichloroacetic Acid/therapeutic use , Retinoids/therapeutic use , Mucinoses/complicationsSubject(s)
Darier Disease/complications , Kaposi Varicelliform Eruption/complications , Adult , Female , HumansABSTRACT
OBJECTIVE: To assess the presence of foreign material in the granulomatous cutaneous lesions of patients with systemic sarcoidosis. DESIGN AND SETTING: Observational study reevaluating histological specimens at a university referral hospital. PATIENTS: Sixty-five patients diagnosed as having sarcoidosis who developed granulomatous cutaneous involvement. MAIN OUTCOME MEASURES: To detect the presence of polarizable foreign particles in cutaneous biopsy specimens and to evaluate the association with clinical features of the patients. RESULTS: Granulomatous cutaneous involvement was demonstrated in 65 (15.3%) of 425 patients with systemic sarcoidosis. In 14 (22%) of the 65 patients, the cutaneous biopsy specimen showed foreign particles in polarized light. The skin lesions corresponded to 3 different clinical patterns: an admixture of papules and infiltration of previously undetected minute scars (n = 6); scar sarcoidosis (n = 4); and subcutaneous nodules (n = 4). The lesions were located most frequently in the extremities, involving the knees in 10 patients. CONCLUSIONS: The presence of polarizable foreign body material in granulomatous cutaneous lesions is not infrequent in patients with systemic sarcoidosis. Inoculation of foreign matter from a previous inapparent minor trauma may induce granuloma formation in individuals with sarcoidosis.
Subject(s)
Granuloma, Foreign-Body/pathology , Sarcoidosis/pathology , Skin Diseases/pathology , Skin/pathology , Adult , Aged , Biopsy , Cicatrix/pathology , Diagnosis, Differential , Female , Granuloma, Foreign-Body/diagnosis , Humans , Male , Middle Aged , Sarcoidosis/diagnosisABSTRACT
BACKGROUND: A significant proportion of multiple sclerosis patients develop cutaneous reactions by interferon beta 1b (IFN-beta). The am of this study was to describe clinically and histologically the cutaneous reactions by IFN-beta. PATIENTS AND METHODS: A series of 92 patients with multiple sclerosis in treatment with IFN-beta was followed. Cutaneous biopsy was performed in cases with persistent lesions. RESULTS: 9 out of 92 patients presented eritematous plaques, 4 cutaneous ulcers and 1 sclerodermiform plaques. Vascular thrombosis was demonstrated in 2 cases. CONCLUSIONS: In patients with multiple sclerosis treated with IFN-beta the persistent skin lesions are more frequent in female patients. Generally is not necessary to stop the treatment.
