Photocatalyzed Hydroaminodifluoroalkylation of Alkenes.

The synthesis of undescribed ß-aminodifluoroethylsulfinates and their uses in the hydroaminodifluoroalkylation of alkenes is reported. This reaction is performed in the presence of a photocatalyst (4CzIPN, Ru complexes) and enables the direct incorporation of a ß-difluoroamine moiety into vinylic aryls, unactivated alkenes, and electron-rich, or -deficient alkenes. The mechanism was studied, and the formation of a gem-difluoromethyl radical was observed after the selective oxidation of the sulfinate function.