[Not Available]. / Etude de la formation des complexes en solution aqueuse-III Nouvelle methode d'affinement des constantes de stabilite des complexes et des autres parametres des titrages protometriques.

This paper describes the theoretical basis of a new program for refinement of complex stability constants together with the other parameters of various protometric titrations. The method is based on minimization of the sum of the weighted squares of the residuals of the experimental variables reagent volume and E or pH. A new exploitation of mathematical relations allows simultaneous refinement of the various parameters and unknown free ion concentrations. After convergence, the program PROTAF also provides the adjusted values of experimental variables.

[Not Available]. / Etude de la formation des complexes en solution aqueuse-I. Methode protometrique informatisee de determination des concentrations des ions libres en solution (methode CILS) et d'estimation des constantes de stabilite des complexes: choix critique des modalites d'application a partir d'un exemple simule.

In the study of complex formation in aqueous solution by means of pH measurements, it is very useful to know the free ion concentrations in order to find each species composition and then calculate approximate values of their stability constants. From the pH determination alone, the unmeasured free ion concentrations can be calculated by a method in which a minimum number of integration and derivation steps are required. This process, called CILS, has been entirely computerized, and its conditions of application are illustrated with a simulated example.

[Gas-liquid chromatographic assay of a new antineoplastic agent, 1,3,3,5,5-pentakis-(azaridino)lambda 6-2,4,6,3 lambda 5, 5 lambda 5-thiatriazadiphosphorine-1-oxide. Application to pharmacokinetic studies]. / Dosage par chromatographie gaz-liquide d'un nouvel antitumoral, 1,3,3,5,5-pentakis-(azaridino)-lambda 6,2,4,6,3 lambda 5,5 lambda 5-thiatriazadiphosphorine-1-oxyde. Applications aux études pharmacocinétiques.

A method for the assay of 1,3,3,5,5-pentakis-(azaridino)-lambda 6,2,4,6,3 lambda 5,5 lambda 5-thiatriazadiphosphorine-1-oxide (SOAz), a new anticancer drug of which the clinical trials are in progress, is described. This method is based on capillary gas chromatography using a thermionic detector. The lower detection limit was 100 pg per injection and a coefficient of variation smaller than 5% could be obtained when parathion was used as external standard. The method is suitable for biological samples and therefore has been proposed for clinical pharmacokinetic studies as well as for the determination of patterns of SOAz distribution in several organs of the mouse. A preliminary clinical study showed that the serum decay curves of SOAz could be fitted to an open two-compartment model for drug disappearance.