Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
J Steroid Biochem Mol Biol ; 151: 66-73, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25446886

ABSTRACT

Cytochrome b5 (cyt-b5) is a relatively small haemoprotein which plays an important role in the regulation of mammalian steroidogenesis. This unique protein has the ability to modulate the activity of key steroidogenic enzymes via a number of diverse reaction mechanisms. Cyt-b5 can augment the 17,20-lyase activity of CYP17A1 by promoting the interaction of CYP17A1 and POR; enhance the 16-ene-synthase activity of CYP17A1 by acting as an electron donor; and enhance the activity of 3ßHSD by increasing the affinity of 3ßHSD for its cofactor NAD(+). We review the modulation of CYP17A1 and 3ßHSD activity by cyt-b5 and discuss the reaction mechanisms associated with each activity. The physiological importance of cyt-b5 in regulating mammalian steroidogenesis is presented and the impact of inactivating cyt-b5 mutations are reviewed. This article is part of a Special Issue entitled 'Steroid/Sterol signaling'.


Subject(s)
Cytochromes b5/metabolism , Steroid 17-alpha-Hydroxylase/metabolism , 3-Hydroxysteroid Dehydrogenases/metabolism , Adrenal Hyperplasia, Congenital/enzymology , Adrenal Hyperplasia, Congenital/genetics , Animals , Cytochromes b5/genetics , Humans , Mutation , NAD/metabolism , Steroids/biosynthesis
SELECTION OF CITATIONS
SEARCH DETAIL
...