ABSTRACT
Partial liquid ventilation is proposed as an alternative ventilation strategy to reduce surface tension, increase alveolar recruitment, and decrease inflammation. Studied in acute respiratory distress and other indications, liquid ventilation is being revisited for infants with bronchopulmonary dysplasia. Perfluorooctyl bromide used for liquid ventilation is radiopaque, allowing radiographic visualization of lung liquid ventilation patterns that may provide additional insight into pulmonary pathophysiology. Current protocols utilize reduced liquid dosing, resulting in unique imaging features. We discuss optimal radiographic technique and report initial ultrasound evaluation results. With renewed interest in partial liquid ventilation, it may be helpful for pediatric radiologists to familiarize themselves with the clinical use and radiographic appearance of liquid ventilation material.
Subject(s)
Bronchopulmonary Dysplasia/diagnostic imaging , Bronchopulmonary Dysplasia/therapy , Liquid Ventilation/methods , Ultrasonography/methods , Female , Fluorocarbons , Humans , Hydrocarbons, Brominated , Infant, Newborn , Infant, Premature , Male , Prospective StudiesABSTRACT
OBJECTIVE: Compare the physiologic, histologic, and biochemical findings of tidal and partial liquid ventilation (PLV) with gas ventilated lambs with an acute lung injury. DESIGN: Experimental, prospective randomized controlled study. SETTING: School of medicine, department of physiology. SUBJECTS: Eighteen newborn lambs (
