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5.
Rev Med Interne ; 40(8): 533-535, 2019 Aug.
Article in French | MEDLINE | ID: mdl-31201015

ABSTRACT

INTRODUCTION: Weight loss, myalgias, neurologic manifestations and arterial hypertension are common features of polyarteritis nodosa (PAN) at diagnosis. Temporal arteritis is a rarer manifestation of PAN, more suggestive of giant cell arteritis (GCA). CASE: We report the case of a 77-year-old woman who presented with fatigue, weight loss, fever, neck pain, jaw claudication and cough, diagnosed with giant cell arteritis. Diagnosis was reconsidered in favour of a medium and small-sized vessels necrotizing vasculitis corresponding to PAN because of steroid dependence, mononeuritis and suggestive histological features. CONCLUSION: Although temporal arteritis is suggestive of GCA, other causes of temporal arteritis can be identified with temporal artery biopsy.


Subject(s)
Polyarteritis Nodosa/diagnosis , Aged , Biopsy , C-Reactive Protein/analysis , Diagnosis, Differential , Female , Giant Cell Arteritis/diagnosis , Humans , Temporal Arteries/pathology
6.
Phys Rev Lett ; 109(20): 202503, 2012 Nov 16.
Article in English | MEDLINE | ID: mdl-23215476

ABSTRACT

We report on direct time-of-flight based mass measurements of 16 light neutron-rich nuclei. These include the first determination of the masses of the Borromean drip-line nuclei (19)B, (22)C, and (29)F as well as that of (34)Na. In addition, the most precise determinations to date for (23)N and (31)Ne are reported. Coupled with recent interaction cross-section measurements, the present results support the occurrence of a two-neutron halo in (22)C, with a dominant ν2s(1/2)(2) configuration, and a single-neutron halo in (31)Ne with the valence neutron occupying predominantly the 2p(3/2) orbital. Despite a very low two-neutron separation energy the development of a halo in (19)B is hindered by the 1d(5/2)(2) character of the valence neutrons.

7.
Rev Med Interne ; 32(3): e34-6, 2011 Mar.
Article in French | MEDLINE | ID: mdl-20646798

ABSTRACT

Cat scratch disease is usually revealed by a proximal lymphadenopathy related to the inoculation site. We report a 22-year-old female who presented with erythema nodosum and bilateral inguinal lymphadenopathy. Serologic test and lymph node PCR detection for Bartonella henselae were negative. Nevertheless, the patient received doxycycline and clinical manifestations rapidly resolved. A follow-up detection of IgM and IgG against Bartonella henselae performed 1 month later was positive. This case report illustrates an original presentation of cat scratch disease and reminds us the lack of sensitivity of laboratory investigations.


Subject(s)
Cat-Scratch Disease/complications , Erythema Nodosum/microbiology , Lymphatic Diseases/microbiology , Female , Humans , Inguinal Canal , Lymphatic Diseases/pathology , Young Adult
8.
Ann Dermatol Venereol ; 137(5): 359-63, 2010 May.
Article in French | MEDLINE | ID: mdl-20470916

ABSTRACT

BACKGROUND: With 254,525 new cases reported in 2007, leprosy is the worlds' second most widespread form of mycobacteriosis. According to the WHO, eradication of leprosy as a public health problem (defined by less than one case per 10,000 people) has been globally achieved. High endemic zones, however, still subsist. Leprosy rates among children, which reflect a country's endemic level, ranged from 0.55 to 19.2 % in 2006. Due to world population migrations, cases of leprosy are now seen in mainland France, in both children and adults. PATIENTS AND METHODS: We describe three leprosy patients aged under 15 years treated at the Dermatology Unit of Saint Louis Hospital between 1st January 2002 and 31st December 2008. The three cases described account for 3 % of new patients treated for leprosy at Saint Louis Hospital over this 7-year period. All were born in an endemic country. Lesions appeared 18 months after arrival in France in two cases and clinical diagnosis was made in only one case. Due to absence of sensory loss in the lesions, diagnosis was reliant upon histopathological examination in two cases. CONCLUSION: Leprosy should be suspected in children from endemic countries presenting skin lesions, particularly hypochromic lesions, even if there is no sensory loss, regardless of how long they have been living in France.


Subject(s)
Leprosy/diagnosis , Adolescent , Adrenal Cortex Hormones/therapeutic use , Age of Onset , Biopsy , Brazil/ethnology , Child , Drug Therapy, Combination , Endemic Diseases , Female , France/epidemiology , Guinea/ethnology , Humans , India/ethnology , Leprosy/drug therapy , Leprosy/epidemiology , Leprosy/pathology , Male , Retrospective Studies , Rifampin/therapeutic use , Skin/pathology
9.
Ann Dermatol Venereol ; 134(6-7): 548-51, 2007.
Article in French | MEDLINE | ID: mdl-17657181

ABSTRACT

INTRODUCTION: Cutis laxa is a rare disorder characterized by loss of elastic tissue. Several organs are often involved such as the skin, lungs, heart, digestive system or genitourinary tract. It may be inherited or acquired, generalized or localized. Its pathogenesis is unclear. Association of acquired cutis laxa with myeloma or plasma cell dyscrasia is very rare. We report a case of acquired cutis laxa associated with a myeloma. CASE REPORT: A 59 year-old woman was admitted for skin hyperlaxity present for a number of years. Light microscopic examination of a skin sample revealed fragmented elastic fibers. Electron microscopic examination of the elastic network demonstrated numerous large vacuolated cells with the appearance of macrophages around abnormal elastic and collagen fibers of the reticular dermis. In addition, a stage-1 IgG lambda myeloma was detected. The patient was treated by thalidomide for one year. After this treatment, electron microscopy examination did not reveal any large vacuolated cells in the dermis, and elastic and collagen fibers were not modified and skin laxity seemed to be stabilized. DISCUSSION: Acquired cutis laxa may be associated with many systemic diseases or can appear after inflammatory skin diseases. Seven cases of generalized cutis laxa associated with myeloma and four cases associated with plasma cell dyscrasia have been reported in the literature. In our case, as in 2 previously described cases, large vacuolated cells resembling macrophages were seen in the dermis. They were thought to play a role in cutis laxa.


Subject(s)
Cutis Laxa/pathology , Dermis/pathology , Multiple Myeloma/pathology , Cutis Laxa/complications , Cutis Laxa/drug therapy , Female , Humans , Immunosuppressive Agents/therapeutic use , Middle Aged , Multiple Myeloma/complications , Multiple Myeloma/drug therapy , Thalidomide/therapeutic use , Treatment Outcome
10.
Ann Trop Med Parasitol ; 100(4): 307-14, 2006 Jun.
Article in English | MEDLINE | ID: mdl-16762111

ABSTRACT

In a retrospective study set in French Guiana, the efficacy and tolerance of the intramuscular treatment of cutaneous leishmaniasis (CL) with a single injection of pentamidine isethionate, at 7 mg/kg, were compared with those observed, earlier, using two such injections (given 48 h apart). Although 83.6% of the 281 patients given two injections each were cured, the single-injection protocol was generally as effective, curing 78.8% of 137 patients. The single-injection protocol was also associated with fewer adverse effects than the two-injection. In the treatment of "difficult" cases (those with satellite papules or relatively high numbers of amastigotes in their lesions), however, the two-injection protocol appeared significantly more effective than the single-injection. In French Guiana, therefore, patients with CL should be given one injection with pentamidine isethionate and only be given a second, 48 h later, if they have satellite papules and/or relatively high numbers of amastigotes in their lesions.


Subject(s)
Antiprotozoal Agents/administration & dosage , Leishmaniasis, Cutaneous/drug therapy , Pentamidine/administration & dosage , Adult , Antiprotozoal Agents/adverse effects , Drug Administration Schedule , Female , French Guiana/epidemiology , Humans , Injections, Intramuscular , Leishmaniasis, Cutaneous/epidemiology , Male , Pentamidine/adverse effects , Retrospective Studies , Treatment Outcome
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