Subject(s)
Chorionic Gonadotropin/blood , Down Syndrome/blood , Down Syndrome/diagnosis , Mass Screening/methods , Skinfold Thickness , Adult , Biomarkers/blood , Crown-Rump Length , Down Syndrome/diagnostic imaging , Female , Humans , Maternal Age , Neck/diagnostic imaging , Neck/embryology , Pregnancy , Pregnancy Trimester, Second , Pregnancy Trimester, Third , Sensitivity and Specificity , Ultrasonography, PrenatalSubject(s)
Chromosome Aberrations , Neck/diagnostic imaging , Ultrasonography, Prenatal , Female , Gestational Age , Humans , PregnancyABSTRACT
Renal ultrasonography was compared with intravenous pyelography in order to establish the suitability and accuracy of the former investigation as a screening method for ureteric obstruction in patients with carcinoma of the uterine cervix. With a sensitivity of 96.30%, specificity of 96.75%, a positive predictive value of 87.64% and a negative predictive value of 99.09% calculated on a large sample of 420 kidneys, it is recommended that renal ultrasonography is the method of choice in screening for ureteric obstruction in patients with cervical cancer. At the very least it is a suitable and equivalent alternative to intravenous pyelography in such patients.
Subject(s)
Kidney/diagnostic imaging , Ureteral Obstruction/diagnosis , Urography , Uterine Cervical Neoplasms/complications , Female , Humans , Ultrasonography , Ureteral Obstruction/etiology , Uterine Cervical Neoplasms/diagnostic imagingABSTRACT
PIP: 5 cases of vascular complications--hemorrhagic stroke, myocardial infarction, retinal vein thrombosis, thrombotic stroke and deep vein thrombosis--in young women taking low dose oral contraceptives are described from the Department of Obstetrics and Gynecology, University of the Witwatersrand, Johannesburg, South Africa. The hemorrhagic stroke occurred in 1987 in a 24-year old heavy smoker taking Triphasil (Wyeth) for 12 months. She recovered fully. A 34-year old woman had an anteroseptal infarction while on Minovlar ED (Schering, 50 mcg ethinyl estradiol and 1 mg norethisterone acetate) for 2 years. She had no risk factors other than smoking 5 cigarettes daily. The woman with retinal vein thrombosis had 2 episodes, the 1st while taking Restovar 28 (Organon, 37.5 mcg ethinyl estradiol and 0.75 mg lynestrenol) for 7 years. 19 months later she began Diane (Schering AG, 50 mcg ethinyl estradiol and 2 mg cyproterone acetate) and had a bilateral retinal vein thrombosis leaving her partially blind. The woman with thrombotic stroke was 24 when she was struck in 1986, after 1 year of taking Logynon ED (Schering AG, 6/5/7 days, 30,40/40 mcg ethinyl estradiol and o.5/0.75/0.125 mg levonorgestrel). The patient with deep vein thrombosis was 19, smoked, and had used Triphasil for 2.5 years.^ieng
Subject(s)
Cardiovascular Diseases/chemically induced , Contraceptives, Oral, Combined/adverse effects , Adult , Cardiovascular Diseases/epidemiology , Causality , Contraceptives, Oral, Combined/classification , Contraceptives, Oral, Combined/supply & distribution , Female , Humans , IncidenceABSTRACT
The incidence of postoperative hyperamylasemia was evaluated in 131 patients who underwent obstetric and gynecologic procedures. Preoperative and postoperative serum amylase levels were determined in 178 patients who underwent routine surgical procedures. In our sample, we could not document any elevations in serum amylase levels after operations. These findings contradict those of previous reports of a high incidence of postoperative hyperamylasemia after surgical procedures except those performed upon the gastrointestinal tract. Furthermore, in spite of the fact that the female internal genitalia is rich in amylase and that pregnancy is considered a predisposing condition for the development of postoperative pancreatitis, the preoperative and postoperative serum amylase levels were consistently within normal range. We would like to conclude that the manipulation of female internal genitalia, pregnant or not, does not induce hyperamylasemia. Therefore, hyperamylasemia in postoperative gynecologic and obstetric patients should alert the clinician to the possibility of postoperative pancreatitis. We believe that our findings should be confirmed on large samples of patients.
Subject(s)
Amylases/blood , Genitalia, Female/surgery , Pregnancy Complications/surgery , Female , Humans , Pregnancy , Pregnancy Complications/enzymologyABSTRACT
A rare case of true necrotizing fasciitis arising from a spontaneously drained Bartholin's abscess is described. The presentation, diagnosis and treatment of this condition are discussed, and the literature on similar cases arising from the female genital tract is reviewed, emphasizing the importance of early and aggressive surgical excision of all involved tissues.
Subject(s)
Abscess/complications , Bartholin's Glands , Fasciitis/etiology , Adult , Fasciitis/pathology , Fasciitis/surgery , Female , Humans , Necrosis , Vulvar Diseases/complicationsABSTRACT
The levels of estrogen and progesterone receptors in normal and abnormal uterine cervices were determined. The study group consisted of 14 patients with cervical intraepithelial neoplasia (CIN III) and 7 patients with invasive carcinoma of the cervix (stage IB-IIA). The control group included 23 patients who underwent total abdominal hysterectomy for menorrhagia, leiomyoma, etc. The concentration of total estrogen receptors in premalignant and malignant cervices did not differ from the patients with benign conditions of the cervix. The concentration of progesterone receptors was significantly higher in the nonaffected cervices than in the patients with preinvasive and invasive carcinoma of the cervix (P less than 0.05). We have shown that estrogen receptor concentrations do not differ between women with normal and abnormal uterine cervices. Therefore, we feel that the contraceptive pill is not contraindicated in women who have been treated for CIN III. We also maintain that hormone replacement therapy should be given, when indicated, to women who have been castrated following surgery and/or radiotherapy for invasive carcinoma of the cervix.
Subject(s)
Contraceptives, Oral , Estrogens/therapeutic use , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Uterine Cervical Dysplasia/pathology , Uterine Cervical Neoplasms/pathology , Adolescent , Adult , Cervix Uteri/analysis , Contraceptives, Oral/adverse effects , Estrogens/adverse effects , Female , Humans , Hysterectomy , Middle Aged , Neoplasm Staging , Reference Values , Uterine Cervical Dysplasia/analysis , Uterine Cervical Dysplasia/surgery , Uterine Cervical Neoplasms/analysis , Uterine Cervical Neoplasms/surgeryABSTRACT
The Atrial Natriuretic Factor discovered by De Bold in 1981, is currently being investigated by biochemists, physiologists and cardiologists. The physiological effects of this hormone closely resemble the normal changes occurring in pregnancy. Based on the experimental data published, the rise in the concentration of Atrial Natriuretic Factor in normal pregnancies may explain the physiological changes of pregnancy. It is postulated that the failure to induce a rise in the plasma concentration of Atrial Natriuretic Factor with its protective effects against the renin-angiotensin-aldosterone system will cause preeclampsia. A prospective study to compare serial Atrial Natriuretic Factor plasma concentrations with the pregnancy outcome from the point of view of preeclampsia is proposed to test this hypothesis.
Subject(s)
Atrial Natriuretic Factor/physiology , Pre-Eclampsia/physiopathology , Blood Volume , Female , Hemodynamics , Humans , Pregnancy , Uterus/blood supplyABSTRACT
A patient on oestrogen replacement therapy after hysterectomy developed endometriosis and adenocarcinoma. The involvement of the urinary tract and theories on the pathogenesis of endometriosis and adenocarcinoma in relation to oestrogen replacement therapy are discussed.
