[Cardiac effects of Cordemcura in vitro]. / Herzwirkungen von Cordemcura in vitro.

Cordemcura has a dose-dependent inotropic effect in the Langendorff-perfused guinea pig heart, in the isolated spontaneously active atria of the guinea pig as well as in the isolated electrically stimulated rabbit papillary muscle. Tachyphylaxy symptoms and arrhythmogene side-effects have not been observed. The dose-dependent coronardilatory effect caused by Cordemcura as observed at the isolated heart of a guinea-pig appears intensely. The positive inotropic effect by Cordemcura on an isolated electrically stimulated papillary muscle of a rabbit is linked with a significant decrease of the relaxation time t2, whereas there is no change in the time to peak force t1. Both mean velocity of force development S1 as well as the mean velocity of relaxation S2 are increased by Cordemcura.

[Spectrum of the adverse effects of Cordemcura]. / Untersuchungen zum Nebenwirkungsspektrum von Cordemcura.

Side-effects of Cordemcura were verified in a relatively extensive repertoire of methods. Investigations of blood pressure activity, effect on heart frequency as well as PQ and QT times after continuous infusion, influence on diuresis and antidiuresis and behaviour to achieve results of a possible activity of the central nerve system were given priority. The proved vasodilatory qualities of Cordemcura become also evident in the rat blood pressure reduction due to higher dose as a result of i.v. injection. No hypotensive effect could be observed after oral administration of the drug. Heart frequency as well as PQ and QT times after i.v. infusion of 1 X 10(-4) mol/kg/min Cordemcura over a period of 15 min remained unchanged. Doses going far beyond therapeutically applied doses indicate a reduction of diuresis after oral administration of Cordemcura for rats. Only due to these high doses unspecific changes in the behaviour of rats and mice occurred. No specific central nerve system activity could be observed.