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1.
Transplant Proc ; 36(4): 993-4, 2004 May.
Article in English | MEDLINE | ID: mdl-15194345

ABSTRACT

Autologous fascial and synthetic materials have been widely used to repair the stress form of urinary incontinence (SUI) as well as pelvic floor prolapse. The safety and long-term durability of cadaveric fascia lata in orthopedic and ophthalmologic surgery have encouraged urogynecologists to use this material for a sling material. The rationale of placement of a sling from cadaveric fascia lata is based upon decreasing the complication rates caused by autologous and synthetic materials. However, the high costs of the commercially available tissues in Brazil have limited its use in public health. In our institution we developed a cadaveric fascia lata bank, harvesting the material according to the Brazilian Transplantation Legislation and storing it at -70 degrees C. The safety of the tissue is achieved by 25-kGy irradiation. Since 1999, 30 patients have undergone surgery using material from five donors in repairs for stress urinary incontinence and pelvic floor prolapse at a mean of 34 months' follow-up (ranging from 30 to 40 months), there was no evidence of rejection. Therefore, we have shown the safety of cadaveric fascia lata harvested and treated as described above in our group of patients.


Subject(s)
Fascia Lata/transplantation , Urinary Incontinence, Stress/surgery , Cadaver , Female , Follow-Up Studies , Humans , Time Factors , Tissue Banks , Tissue Preservation/methods , Tissue and Organ Harvesting/methods
2.
Transplant Proc ; 36(4): 995-6, 2004 May.
Article in English | MEDLINE | ID: mdl-15194346

ABSTRACT

OBJECTIVES: The technique and outcomes of patients treated with allografts or autografts as pubovaginal sling are compared. METHODS: Fascia lata was included among the tissues harvested from brain-dead patients considered for multiple organ donation. After informed consent, segments of allograft (group A) cadaveric fascia lata autografts (group B) were compared with used for sling operations in 60 women from 37 to 73 years of age (mean 53.4 years), who presented with stress incontinence requiring a pubovaginal sling. RESULTS: At a mean follow-up of 36 months (range = 22 to 44 months), 40% of group A patients were cured and 28% were improved. At a mean follow-up of 33 months (range = 24 to 41) 70% of group B patients were cured and 20% improved (P <.05). There were no adverse outcomes of sling erosion or infection in either group. Placement of allograft sling took an average of 62 minutes while the mean duration of sling placement requiring fascial harvest was 81 minutes (P <.05). The mean duration of hospital stay was shorter in the allograft (1.25 days) than the autograft (2.48 days) group (P <.05). CONCLUSION: Use of allografts was associated with a shorter operative time and duration of hospital stay compared to an autograft, but the 3-year continence rate was lower in the autograft group.


Subject(s)
Fascia Lata/surgery , Transplantation, Homologous/methods , Urinary Incontinence, Stress/surgery , Adult , Aged , Brain Death , Cadaver , Female , Follow-Up Studies , Humans , Middle Aged , Retrospective Studies , Time Factors , Tissue Donors , Transplantation, Autologous/methods , Vagina/surgery
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