Teratologic effects of d,1-2-(o-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride (ketamine hydrochloride) in rats.

Studies were conducted of the teratologic effects of ketamine hydrochloride in rats. Ketamine treatment had no significant effect on the number of animals per litter. The histological examination of heart, liver, and kidney showed focal nuclear hypochromatosis and interfibrillary edema; diffuse hemopoietic cell infiltration, and parenchymal cell degeneration; proximal convoluted tubule degeneration. The degenerative effect is also dependent upon the dose and the duration of treatment.