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1.
Genes (Basel) ; 13(2)2022 02 21.
Article in English | MEDLINE | ID: mdl-35205433

ABSTRACT

Patients with type 1 diabetes (T1D) have a higher risk of developing cardiovascular disease (CVD), which is a major cause of death in this population. This study investigates early markers of CVD associated with clinical data and autosomal ancestry in T1D patients from an admixed Brazilian population. A cross-sectional study was conducted with 99 T1D patients. The mean age of the study sample was 27.6 years and the mean duration of T1D was 14.4 years. The frequencies of abnormalities of the early markers of CVD were 19.6% in the ankle-brachial index (ABI), 4.1% in the coronary artery calcium score (CACS), and 5% in the carotid Doppler. A significant percentage of agreement was observed for the comparison of the frequency of abnormalities between CACS and carotid Doppler (92.2%, p = 0.041). There was no significant association between the level of autosomal ancestry proportions and early markers of CVD. The ABI was useful in the early identification of CVD in asymptomatic young patients with T1D and with a short duration of disease. Although CACS and carotid Doppler are non-invasive tests, carotid Doppler is more cost-effective, and both have limitations in screening for CVD in young patients with a short duration of T1D. We did not find a statistically significant relationship between autosomal ancestry proportions and early CVD markers in an admixed Brazilian population.


Subject(s)
Cardiovascular Diseases , Diabetes Mellitus, Type 1 , Adult , Ankle Brachial Index , Biomarkers , Brazil/epidemiology , Cardiovascular Diseases/genetics , Cross-Sectional Studies , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 1/genetics , Humans
2.
Rev. Soc. Bras. Med. Trop ; 34(6): 527-530, nov.-dez. 2001. tab
Article in Portuguese | LILACS | ID: lil-316685

ABSTRACT

Centopéias são animais invertebrados do filo dos artrópodes e da classe Chilopoda. Este trabalho objetiva estudar o perfil dos acidentes por centopéias notificados pelo "Centro de Informações Toxicológicas de Belém" (CIT-Belém). Foram estudados 76 protocolos registrados no período de março de 1998 a março de 2000. Corresponderam a 16,7 por cento dos acidentes por animais peçonhentos, superados apenas pelo ofidismo (44,4 por cento) e escorpionismo (20,5 por cento). O local do acidente foi a residência em 86,8 por cento dos casos. A faixa etária 20 - 49 anos foi a mais acometida (64,4 por cento) e 61,8 por cento dos casos registrados pertenciam ao sexo feminino. Membros superiores foram a parte do corpo mais acidentada (47,4 por cento). Dor local ocorreu em 95,8 por cento dos pacientes e edema local leve em 52,1 por cento. O tratamento foi predominantemente sintomático; 94,7 por cento evoluíram para a cura e ignora-se a evolução nos outros 5,3 por cento. Sugere-se que o acidente por centopéia é benigno e doméstico e que tratamentos analgésicos são suficientes


Subject(s)
Humans , Animals , Male , Female , Arthropod Venoms , Bites and Stings , Animals, Poisonous , Bites and Stings , Brazil , Housing , Prospective Studies
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