Self-Consistent Modeling of Gravitational Theories beyond General Relativity.

The majority of extensions to general relativity (GR) display mathematical pathologies-higher derivatives, character change in equations that can be classified within partial differential equation theory, and even unclassifiable ones-that cause severe difficulties to study them, especially in dynamical regimes. We present here an approach that enables their consistent treatment and extraction of physical consequences. We illustrate this method in the context of single and merging black holes in a highly challenging beyond GR theory.

Artificial intelligence applied to potential assessment and talent identification in an organisational context.

Our study provides valuable insights into the relationship between artificial intelligence (AI) and Human Resource Management (HRM). We have minimised bias and ensured reliable findings by employing a systematic literature review and the PRISMA statement. Our comprehensive synthesis of the studies included in this research, along with a bibliometric analysis of articles, journals, indexes, authors' affiliations, citations, keyword co-occurrences, and co-authorship analysis, has produced robust results. The discussion of our findings focuses on critical areas of interest, such as AI and Talent, AI Bias, Ethics and Law, and their impact on Human Resource (HR) management. Our research highlights the recognition by organisations of the importance of talent management in achieving a competitive advantage as higher-level skills become increasingly necessary. Although some HR managers have adopted AI technology for talent acquisition, our study reveals that there is still room for improvement. Our study is in line with previous research that acknowledges the potential for AI to revolutionise HR management and the future of work. Our findings emphasise the need for HR managers to be proactive in embracing technology and bridging the technological, human, societal, and governmental gaps. Our study contributes to the growing body of AI and HR management knowledge, providing essential insights and recommendations for future research. The importance of our study lies in its focus on the role of HR in promoting the benefits of AI-based applications, thereby creating a larger body of knowledge from an organisational perspective.

As trials go by: Effects of 2-AFC item repetition on statistical learning performance.

One of the most popular tasks used to test statistical learning (SL) involves asking participants to identify which of two stimuli, a triplet presented during the previous familiarization phase versus a new sequence made of the same stimuli never presented together, is more familiar based on the stream presented before, that is, to perform a two-alternative forced-choice (2-AFC) task. Despite the widespread use of this task, it has come under increasing criticism in current cognitive research due to psychometric flaws. A common practice to improve SL measurement involves increasing the number of 2-AFC trials by presenting the same items (triplets and foils) several times during the test phase. This work aimed to directly analyze the effect that this practice entails by examining how the proportion of correct discriminations of three-syllable nonsense words presented during the familiarization phase of an auditory triplet embedded task changed as the number of 2-AFC item repetitions increased. We also tested whether this effect was modulated by the predictability of the "words" embedded in the auditory streams (high and low) and the conditions under which they were presented to participants (implicit and explicit). Results showed that 2-AFC item repetitions had indeed detrimental effects on SL measurement, as indexed by a significant decrease in the proportion of correct discriminations as the number of items repetitions increased, both in the 2-AFC task performed under implicit and explicit conditions, although, in the first case, only for low-predictable "words." These findings recommend caution when using this strategy to improve SL measurement. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Analysis of government agencies and stakeholders' twitter communications during the first surge of COVID-19 in Brazil.

BACKGROUND: Official authorities are in charge of communicating with the public in a consistent and coherent manner. The impact of social media on managing the coronavirus 2019 (COVID-19) pandemic potentially influenced social behavior in Brazil. OBJECTIVE: Using Twitter, this study analyzes communications about the COVID-19 pandemic from official agencies of the Brazilian government and key public sector decision-makers. METHOD: We captured public Twitter messages about COVID-19 exchanged between authorities at the federal, state, and municipal levels of government. These messages were further classified into guidance and information messages or disinformation messages. Finally, through analysis of tweets and their frequency, we evidenced the level of information generated by the three levels of government. RESULTS: Our analyses show an underestimation of the magnitude of the pandemic by Brazilian government authorities. None of the spheres of government anticipated the imminent health crisis, did not issue good recommendations and guidelines, and did not take preventive actions. CONCLUSION: The lack of governmental actions and adequate guidance in Brazil has led to an explosive increase in infected people and deaths. Surprisingly, this was not due to technical or structural reasons. It resulted from conflicting communication strategies implemented by the federal, state, and municipal governments in attempts to minimize the effects of COVID-19 on their local health structures.

Immunotherapy with nivolumab for the treatment of soft tissue sarcoma with pulmonary metastasis: A case report.

Sarcomas are an unusual group of tumors, accounting for ~1% of cancer in adults. Immunotherapy has been shown to be a potential therapeutic option for the management of patients with cancer. However, there is still insufficient information on the action of immunotherapy on sarcomas. A 16-year-old male patient, diagnosed in December 2013 with grade III soft-tissue sarcoma in the right arm, was admitted to a private oncology service after relapse following surgical treatment. The patient underwent chemotherapy with ifosfamide plus adriamycin for 4 cycles, associated with adjuvant radiotherapy, followed by a new resection to remove the residual lesion. A year later, imaging tests identified pulmonary micronodules, and a new resection was performed. After immunohistochemical evaluation of biopsy, a large presence of programmed cell death 1 ligand 1 (PD-L1) marker was identified in tumor tissue and immunotherapy with nivolumab was performed. At present, the patient is in immunotherapeutic treatment (42 cycles), presenting an excellent general condition and without any symptoms, and a decrease in neoplastic lung masses. The literature recommends three cycles of anthracycline plus ifosfamide as adjuvant therapy to surgical treatment. Combined surgery plus adjuvant therapy has shown benefits in malignant tumors. Immunotherapy is an important therapeutic option for soft-tissue sarcomas with high programmed cell death protein 1 (PD-1)/PD-L1 expression. Treatment for high grade soft tissue sarcoma (STS) is still limited, due to tumor heterogeneity, and further studies are needed to consolidate the possibility of using immunotherapy to treat these neoplasms. When significant levels of specific biomarkers are present in tumor tissue, immunotherapy may be beneficial as shown by the present case report.

O câncer de mama no estado do Pará, Brasil, e o papel da Liga Acadêmica de Oncologia na promoção da saúde feminina: um relato de experiência / Breast cancer in the state of Pará, Brazil, and the role of Liga Acadêmica de Oncologia on the promotion of women health: an experience report

INTRODUÇÃO: O câncer de mama é um grande agressor da saúde feminina, além de ser o segundo câncer mais incidente nessa população. É uma doença geralmente insidiosa, acometendo mulheres em idade mais avançada. Quando presente em mulheres mais jovens, tem pior prognóstico. Assim, diagnóstico e tratamento precoces são essenciais para o bom prognóstico das pacientes. O objetivo deste estudo foi fazer um relato de experiência sobre uma ação de extensão realizada pela Liga Acadêmica de Oncologia do Pará (LAOPA) para detecção do câncer de mama em uma população de risco e discutir a importância de ações de extensão no Pará. RELATO DE EXPERIÊNCIA: Um mutirão de rastreio do câncer de mama foi realizado no município de Ananindeua, Pará, em outubro de 2015. Uma capacitação para os acadêmicos foi feita por meio de aulas expositivas sobre câncer de mama e um treino prático foi realizado em modelos anatômicos. A ação foi dividida em espaços, alguns dos quais destinavam-se às consultas e outro, a uma palestra com o tema "desmistificando o câncer de mama". CONCLUSÃO: O 5º Mutirão da Mama se mostrou extremamente importante para o contexto da saúde feminina no Pará, pois ofertou atendimento clínico e exames gratuitos a uma população de risco para a neoplasia de mama, tornando-se também um projeto símbolo da LAOPA.

INTRODUCTION: Breast cancer is a major female health agressor and the second most common cancer in women. It is usually na insidious disease, affecting women at a later age. When presente in younger women, prognosis is worse. Thus, early diagnosis and treatment are essential for a good prognosis. The objective of this study was to present an experience report about na extension action performed by Liga Acadêmica de Oncologia do Pará (LAOPA) to detect breast cancer in a population at risk and to discuss the importance of extension actions in the State of Pará, Brazil. EXPERIENCE REPORT: A breast cancer screening effort was conducted in the city of Ananindeua, in October 2015. The academics were trained in lectures on breast cancer and through practice with anatomical models. The project was divided by locales, some of which were destined to the consultations and other to a lecture on the topic "demystifying breast cancer". CONCLUSION: The 5th Mutirão da Mama was extremely importante for the female health context in Pará, since it offered clinical care and free examination tests to a population at risk for breast neoplasia, also becoming a symbol project of LAOPA.

A escolarização das pessoas com deficiência no Brasil: atendimento, atraso e progressão no ensino fundamental segundo o Censo 2000 / La escolarización de personas con discapacidad en Brasil: atención, atraso y progresión en la enseñanza fundamental según el Censo 2000 / The schooling of disabled people in Brazil: attendance, retention and progression in primary education according to the 2000 Census

O presente artigo tem por objetivo evidenciar a implicação das deficiências sobre o atendimento, o atraso e a progressão escolar no ensino fundamental. Para tal, é utilizada a modelagem estatística logística binária. Após apresentação dos diferentes conceitos de deficiência, por meio do Censo 2000, transcorre-se a análise dos quesitos pretendidos. A progressão escolar é pesquisada por meio da medida nomeada probabilidade de progressão por série (PPS), dos três pontos de maior relevância no desenvolvimento do ensino fundamental. Os resultados indicam grande disparidade entre as deficiências na determinação dos elementos investigados. Em geral, todas as condições se mostram como fatores que desfavorecem o desenvolvimento na carreira escolar. Porém, a implicação das deficiências sobre as PPS se reduz com o avanço no ensino fundamental, sendo também menos significativa a cada etapa sequente. Entre os quesitos analisados, o atraso escolar demonstrou sofrer relevante variação, devido ao controle por fatores de natureza socioeconômica. No mais, este trabalho contém resultados e aponta contributos para o desenvolvimento científico dessa área de estudo.

El presente artículo tiene como objetivo poner en evidencia la implicación de las diferentes discapacidades en áreas como la atención, el atraso y la progresión escolar en la enseñanza fundamental. Para ello, se utiliza el modelo estadístico logístico binario. Tras la presentación de los diferentes conceptos de discapacidad, usando como instrumento el Censo 2000, transcurre el análisis de las áreas mencionadas anteriormente. La progresión escolar se investiga por medio de una medida denominada Probabilidad de Progresión por Clase11 (PPS), tratándose, además, de uno de los tres puntos de mayor relevancia en el desarrollo de la enseñanza fundamental. Los resultados indican una gran disparidad entre las discapacidades en la determinación de los elementos investigados. En general, todas las condiciones se muestran como factores que desfavorecen el desarrollo en la carrera escolar. Sin embargo, la implicación de las discapacidades sobre la PPS se reduce con el avance en la enseñanza fundamental, siendo también menos significativa en cada una de las etapas siguientes. Entre los ámbitos analizados, el atraso escolar demostró sufrir una relevante variación, debido al control por factores de naturaleza socioeconómica. En lo restante, este trabajo contiene resultados y contribuye al desarrollo científico de esta área de estudio.

This article aims to highlight the implications of disabilities in attendance, retention and progression in primary schools, using binary logistic statistical modeling. After presenting the different concepts of disability using the 2000 Census, we analyze the following questions. School progression is investigated using a measure called Grade Progression Probability (GPP), with the three most relevant points in the development of basic education. The results show wide disparity disabilities in determining the elements investigated. In general, all conditions are factors discouraging development in the school life. However, the implication of disabilities on the GPP decreases with each grade in elementary school, being less significant at each subsequent grade. Among the issues we analyzed, grade retention demonstrated a more significant variation, given the nature of controlling socioeconomic factors. Moreover, this study contains results and points to contributions to the scientific development of this area.

Condicionamento físico aeróbio moderado promove redução no rápido ganho de peso de ratos adultos desnutridos nos períodos de gestação e lactação / Moderate aerobic physical conditioning reduces the fast weight gain of adult rats malnourished during pregnancy and lactation

OBJETIVO: Foram avaliados os efeitos do condicionamento físico aeróbio moderado sobre o peso corporal e o ganho de peso de animais submetidos à desnutrição na gestação e lactação e alimentados com dieta normoprotéica após o desmame. MÉTODOS: Ratos machos Wistar foram gerados e amamentados por nutrizes alimentadas com dieta normoprotéica (caseína 17 por cento) e dieta hipoprotéica (caseína 8 por cento), formando os grupos Nutridos (n=18) e Desnutridos (n=17) inicialmente e, após o desmame, foram alimentados com dieta normoprotéica padrão do biotério (Labina®, Purina). Aos 60 dias de vida, os animais foram subdivididos em quatro grupos: Nutrido Sedentário (n=9), Nutrido Condicionado (n=7), Desnutrido na Gestação e Lactação Sedentário (n=8) e Desnutrido na Gestação e Lactação Condicionado (n=9). O condicionamento físico aeróbio moderado foi realizado em esteira elétrica durante 8 semanas, 5 dias/ semana, 60min/dia e os animais sofreram eutanásia após o término do protocolo. Realizaram-se as análises do peso corporal (g) e do ganho de peso corporal ( por cento). RESULTADOS: Observou-se menor peso corporal nos grupos Desnutrido na Gestação e Lactação Sedentário (247,00: 134,00 - 335,00) e Desnutrido na Gestação e Lactação Condicionado (245,00: 166,00 - 324,50) comparados respectivamente, aos grupos Nutrido Sedentário (303,75: 176,00 - 372,00) e Nutrido Condicionado (290,25: 190,00 - 372,00) (p<0,05). O ganho de peso mostrou-se maior nos animais do grupo Desnutrido na Gestação e Lactação Sedentário (35,40: -6,20 - 77,10) comparado ao Nutrido Sedentário (24,30: -7,50 - 44,30) (p<0,05) e comparado ao Desnutrido na Gestação e Lactação Condicionado (20,50: -2,30 - 59,00) (p<0,05). CONCLUSÃO: O condicionamento físico aeróbio moderado exerceu um efeito benéfico por ter reduzido o rápido ganho de peso (catch up) dos animais adultos desnutridos na gestação e lactação e alimentados com dieta normoprotéica após o desmame.

OBJECTIVE: The objective of this study was to assess the effects of moderate aerobic physical conditioning on the body weight and weight gain of rats whose mothers were fed a low protein diet during gestation and lactation. METHODS: Male Wistar rats were bred from dams fed a normal- (17 percent casein) or low-protein (8 percent casein) diet, constituting the initial nourished (n=18) and malnourished (n=17) groups. After weaning, they were fed the standard diet of the laboratory, with normal protein content (Labina®, Purina). At the age of 60 days, the animals were divided into four groups: inactive and well nourished (n=9), active and well nourished (n=7), inactive and malnourished from conception until weaning (n=8) and active and malnourished from conception until weaning (n=9). Moderate aerobic physical conditioning was done on a treadmill for 8 weeks, 5 days per week, 60 minutes per day. All animals were killed after this training period. Body weight (g) and weight gain ( percent) were analyzed. RESULTS: Lower body weights were seen in animals that were inactive and malnourished from conception until weaning (247.00: 134.00 - 335.00) and active and malnourished from conception until weaning (245.00: 166.00 - 324.50) when compared with the animals that were inactive and well nourished (303.75: 176.00 - 372.00) and active and well nourished (290.25: 190.00 - 372.00) (p<0.05). Weight gain was higher in the animals from the inactive and malnourished group (35.40: -6.20 - 77.10) in comparison with the inactive and well nourished group (24.30: -7.50 - 44.30) (p<0.05) and the active and malnourished group (20.50: 2.30 - 59.00) (p<0.05). CONCLUSION: Moderate aerobic physical conditioning had a beneficial effect on the animals that were malnourished during their mothers' gestation and lactation as it reduced their rapid weight gain.

Aspectos morfologicos e citopatologicos das lesoes ateroscleroticas em criancas e adolescentes e sua aterogenese / Morphological and cytopathological aspects of atherosclerotic lesions in children and adolescents and their atherogenesis

Revisao da literatura sobre os aspectos morfologicos e citopatologicos das lesoes ateroscleroticas em criancas e adolescentes abordando,outrossim, o mecanismo aterogenetico implicado na formacao e desenvolvimento das mesmas. Aborda, ainda, a...