ABSTRACT
Any disease or traumatic event that involving the integrity of the urinary tract or of the bowel, may led to an entero-vesical fistula formation. The clinical onset of this pathology, is described on the basis of usual clinical pictures and of some unusual cases mimicking a bladder cancer. Moreover, the guide lines for a gold standard in the diagnosis and treatment of such pathology are described.
Subject(s)
Intestinal Fistula/surgery , Urinary Bladder Fistula/surgery , Humans , Intestinal Fistula/diagnosis , Urinary Bladder Fistula/diagnosisSubject(s)
Abnormalities, Drug-Induced/etiology , Cyclophosphamide/toxicity , Doxorubicin/toxicity , Embryo Loss/chemically induced , Fetal Death/chemically induced , Animals , Birth Weight/drug effects , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Drug Administration Schedule , Female , Gestational Age , Humans , Pregnancy , Rats , Rats, Inbred StrainsABSTRACT
Among 56 patients with elevated thromboembolic risk, subject to intravenous infusion of heparin, we have determined the relation between hematic concentration of heparin and activated partial thromboplastin time (APTT), surveyed by two reagents with different sensitivity. The obtained results shown a very good correspondence without significant differences between the APTT reagents used, especially inside the therapeutic range. Otherwise a good correlation is demonstrated between methods, relative to two different chromogenic substrates, applied to heparin determination.
Subject(s)
Blood Coagulation Tests , Heparin/blood , Partial Thromboplastin Time , Thromboembolism/blood , Aged , Female , Humans , Male , Middle AgedABSTRACT
Di-BHA, 2,2'-dihydroxy-3,3'-di-t-butyl-5,5'-dimethoxy-diphenyl, was isolated as the product of the reaction of either commercial horseradish peroxidase or partially purified rat intestine peroxidase (Donor-H(2)O(2) oxidoreductase, EC 1.11.1.7.) and hydrogen peroxide with 2-t-butyl-4-methoxyphenol (BHA). BHA, Di-BHA and other cyclic compounds possessing a hydroxyl group in the ring were found to be competitive inhibitors with respect to guaiacol, and non-competitive inhibitors with respect to hydrogen peroxide in a system containing guaiacol, hydrogen peroxide and peroxidase. A free radical intermediate generated during peroxidatic oxidation of BHA was detected and identified by means of EPR spectroscopy. It was estimated that during one hour incubation the peroxidase activity present in the rat ileum mucosa is able to oxidise 12mumoles BHA at a saturating concentration. It is suggested that peroxidative oxidation at the intestinal wall may represent a contribution to the inactivation of some phenol derivatives potentially toxic to mammals.
