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Chem Pharm Bull (Tokyo) ; 56(2): 181-4, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18239304

ABSTRACT

Following our previous studies in the field of anticonvulsant agents, we planned a one-pot solution-phase parallel synthesis (SPPS) of a small library of new 1,2,3,4-tetrahydroisoquinoline derivatives. The activity against audiogenic seizures in DBA/2 mice of the newly synthesized compounds has also been evaluated.


Subject(s)
Anticonvulsants/chemical synthesis , Anticonvulsants/pharmacology , Tetrahydroisoquinolines/chemical synthesis , Tetrahydroisoquinolines/pharmacology , Animals , Epilepsy, Reflex/prevention & control , Female , Indicators and Reagents , Magnetic Resonance Spectroscopy , Male , Mice , Mice, Inbred DBA , Solutions , Structure-Activity Relationship
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