1.
Br J Clin Pharmacol
; 2(3): 227-32, 1975 Jun.
Article
in English
| MEDLINE
| ID: mdl-791321
ABSTRACT
1 Hospitalized patients suffering from insomnia were treated with N-demethyldiazepam (30 mg p.o.) for 10 days, while continuing treatment with nortriptyline (75 or 100 mg daily). 2 Clinical evaluation performed by objective rating scales showed a positive therapeutic effect. No correlation was found however between drug plasma levels and clinical efficacy. A high inter-individual variability was observed. 3 In three cases the N-demethyldiazepam disappearance curve showed a biexponential decay, with a slow first component followed by a faster one. 4 Compared with diazepam the tested drug has a longer plasma apparent half-life and a lower relative clearance.
Subject(s)
Diazepam/analogs & derivatives , Nordazepam/therapeutic use , Nortriptyline/therapeutic use , Sleep Initiation and Maintenance Disorders/drug therapy , Adult , Aged , Clinical Trials as Topic , Drug Evaluation , Drug Therapy, Combination , Half-Life , Humans , Male , Middle Aged , Nordazepam/metabolism , Placebos
2.
Biomedicine
; 19(5): 202-4, 1973 May 20.
Article
in English
| MEDLINE
| ID: mdl-4577013