1.
Proc Soc Exp Biol Med
; 196(3): 301-6, 1991 Mar.
Article
in English
| MEDLINE
| ID: mdl-1998007
ABSTRACT
Progesterone (P), a major hormone of pregnancy, was selected for study under the conditions of an intact utero-placental-fetal unit. A preparation of the canine gravid uterus, near term, is described and shown to permit observation of the metabolic relationships of the steroid hormone P between maternal and fetal organisms. [1,2-3H] P or [7 alpha-3H]P was injected into pups, while [4-14C]P was injected into the uterine circulation. Perfusion was continued for 1 hr with excellent survival of the pups. Identified metabolites in the fetal and maternal tissues suggest a metabolic pool that is shared throughout the unit.
Subject(s)
Fetus/metabolism , Placenta/metabolism , Progesterone/metabolism , Animals , Brain/metabolism , Chromatography, Gas , Chromatography, High Pressure Liquid , Dogs , Female , Intestinal Mucosa/metabolism , Liver/metabolism , Lung/metabolism , Maternal-Fetal Exchange , Pregnancy , Uterus/metabolism
2.
J Chromatogr
; 336(2): 361-7, 1984 Dec 12.
Article
in English
| MEDLINE
| ID: mdl-6530469
3.
Proc Soc Exp Biol Med
; 143(4): 1197-200, 1973 Sep.
Article
in English
| MEDLINE
| ID: mdl-4355244
4.
J Clin Endocrinol Metab
; 32(6): 801-18, 1971 Jun.
Article
in English
| MEDLINE
| ID: mdl-4252712
Subject(s)
Meconium/analysis , Steroids/analysis , Sterols/analysis , 17-Hydroxycorticosteroids/analysis , 17-Ketosteroids/analysis , 17-alpha-Hydroxypregnenolone/analysis , Androstanes/analysis , Androsterone/analysis , Bile/metabolism , Chromatography , Chromatography, Gas , Chromatography, Paper , Chromatography, Thin Layer , Dehydroepiandrosterone/analysis , Female , Fetus/metabolism , Glucuronates/analysis , Humans , Infant, Newborn , Intestine, Small/physiology , Maternal-Fetal Exchange , Placenta/metabolism , Pregnancy , Pregnanes/analysis , Pregnenolone/analysis , Spectrum Analysis , Testosterone/analysis
5.
Proc Soc Exp Biol Med
; 131(4): 1389-92, 1969 Sep.
Article
in English
| MEDLINE
| ID: mdl-4309477
6.
J Clin Endocrinol Metab
; 27(2): 211-3, 1967 Feb.
Article
in English
| MEDLINE
| ID: mdl-6018574
7.
J Clin Endocrinol Metab
; 26(2): 128-32, 1966 Feb.
Article
in English
| MEDLINE
| ID: mdl-5905912