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Emergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals.
Pfeifer, Yvonne; Schlatterer, Kathrin; Engelmann, Elisabeth; Schiller, Reinhold A; Frangenberg, Hans Reiner; Stiewe, Doris; Holfelder, Martin; Witte, Wolfgang; Nordmann, Patrice; Poirel, Laurent.
Antimicrob Agents Chemother ; 56(4): 2125-8, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22290940

ABSTRACT

Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative plasmids. Insertion sequence IS1999 (truncated or not by IS1R) was located upstream of the bla(OXA-48) and bla(OXA-162) genes in all of the isolates. Pulsed-field gel electrophoresis typing indicated the clonal transmission of an OXA-48-producing Klebsiella pneumoniae strain in two hospitals.


Subject(s)
Bacterial Proteins/biosynthesis , Enterobacteriaceae Infections/microbiology , Enterobacteriaceae/drug effects , Enterobacteriaceae/enzymology , beta-Lactamases/biosynthesis , Anti-Bacterial Agents/pharmacology , Bacterial Proteins/genetics , Conjugation, Genetic , Cross Infection/microbiology , Cross Infection/transmission , DNA Transposable Elements , Drug Resistance, Multiple, Bacterial/genetics , Electrophoresis, Gel, Pulsed-Field , Enterobacteriaceae Infections/transmission , Escherichia coli/drug effects , Escherichia coli/genetics , Germany , Hospitals , Humans , Microbial Sensitivity Tests , Plasmids/genetics , Polymerase Chain Reaction , beta-Lactamases/genetics
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