A Quality Initiative: A System-Wide Reduction in Serious Medication Events Through Targeted Simulation Training.

INTRODUCTION: Medication administration events (MAEs) are a great concern to the healthcare industry, because they are both common and costly. Pediatric patients pose unique challenges to healthcare systems, particularly regarding the safety of medication administration. Our objectives were to improve adherence to best practices, decrease MAEs, and decrease cost related to error reduction rates by implementing a scenario-based simulation training program for frontline nursing staff in the general care units, emergency departments, and intensive care units within our institution. METHODS: Children's simulation center in conjunction with the medication safety workgroup developed a 2-hour target-specific simulation-based training. This quality initiative focused on implementation of a MAE bundle that included the following three elements: The Five Rights, MedZone, and Independent Double Check. Adherence to the use of bundle elements was monitored via bedside auditing for 18 months after the intervention. This audit was accomplished using an institution-wide MAE reporting system. The 2012 Healthcare Cost and Utilization Project Kids' Inpatient Database and 2014 Children's Hospital Association, Pediatric Health Information System databases were used to estimate cost impact. RESULTS: A total of 1434 nurses from our intensive care units, emergency departments, and general care inpatient units participated in simulation training. Nursing adherence to the MAE bundle in the 18-month period after simulation increased by 33%, from January 2014 to June 2015. Medication administration event monitoring during the preintervention, intervention, and postintervention periods demonstrated a decrease in error rate from 2.5 events per month to 0.86 events per month This error reduction correlated to an estimated charge savings of $165,000 to $255,000 and a cost impact of $90,000 to $130,000 per year. CONCLUSIONS: Target-specific simulation-based training on a large scale has improved adherence with best practice guidelines and has led to a significant reduction in MAEs.

Etiology and Laboratory Abnormalities in Bacterial Meningitis in Neonates and Young Infants.

We conducted a retrospective review of electronic medical records of all cases of bacterial meningitis in neonates and young infants at our institution from 2004 to 2014. Fifty-six cases were identified. The most common causative organism was group B streptococcus, followed by Escherichia coli and then Listeria monocytogenes. Forty-four of the 56 patients in the study had abnormalities of the blood white blood cell (WBC) count. The most common WBC count abnormalities were leukopenia and elevation of the immature to total (I:T) neutrophil ratio. Six patients in the case series lacked cerebrospinal fluid (CSF) pleocytosis. Overall, just 3 of the 56 patients had normal WBC count with differential, CSF WBC count, and urinalysis. Only 1 of the 56 patients was well appearing with all normal lab studies. Our study indicates that bacterial meningitis may occur without CSF pleocytosis but very infrequently occurs with all normal lab studies and well appearance.

Impact of a Pressure Injury Prevention Bundle in the Solutions for Patient Safety Network.

BACKGROUND: Our objective was to describe changes in pressure injury (PI) rates in pediatric hospitals after implementation of an active surveillance and prevention bundle and to assess the impact of bundle elements. METHODS: The Children's Hospitals Solutions for Patient Safety (SPS) Network is a learning collaborative working together to eliminate harm to hospitalized children. SPS used a 3-pronged approach to prevent pressure injuries: (1) active surveillance, (2) implementing and measuring compliance with the prevention bundle, and (3) deploying a wound ostomy team. Among hospitals participating since 2011 (phase 1), we used negative binomial analyses to assess change in PI rates. Only phase 1 hospitals had a baseline period before any prevention bundle intervention. Among all hospitals participating in 2013 (phases 1 and 2), we used funnel charts to assess the association between reliable bundle implementation and PI rates. RESULTS: Among the 33 hospitals that participated in SPS from 2011 to 2013 (phase 1), the rate of stage 3 pressure injuries declined from 0.06 to 0.03 per 1,000 patient-days (P < 0.001). Stage 4 pressure injuries declined from 0.01 to 0.004 per 1,000 patient-days (P = 0.02). Among all 78 hospitals in phases 1 and 2, the cohort that adopted each bundle element, measured compliance, and achieved 80% prevention bundle compliance had significantly lower PI rates compared with all hospitals. CONCLUSIONS: SPS hospitals saw a significant reduction in stage 3 and 4 PIs over a 2-year period. Reliable implementation of each element of a prevention bundle was associated with lower PI rates.

Asthma Care Quality Measures at Children's Hospitals and Asthma-Related Outcomes.

OBJECTIVE: The Joint Commission requires hospitals to report on Children's Asthma Care (CAC) measures, although their relationship to outcomes is not clear. The objective of this study was to (1) characterize metrics hospitals use for asthma, and to (2) determine if the number and type of metrics used is associated with readmission rates. STUDY DESIGN: Pediatric hospital quality leaders were asked to identify asthma metrics utilized by their respective organizations via an online survey. "Use" of metrics was defined as periodically measuring data regardless of performance. Linear regression was used to determine if the number or domain of metrics grouped by topic used was associated with 7-, 30-, and 90-day same-cause readmission rates obtained from the Pediatric Health Information System (PHIS). RESULTS: Among respondents (n = 27, 62.7%), the mean number of metrics used was 20.5 (SD = 9.1, range = 4-38). There was no association between the number or domain type of metrics used and 7-, 30-, or 90-day readmission rates. CONCLUSIONS: Despite using a wide variety of asthma metrics, there was no association between use of any metric or domain of metrics and asthma-related readmission rates. Additional work should identify asthma process measures that are associated with meaningful outcomes.

Impact of Physician Scorecards on Emergency Department Resource Use, Quality, and Efficiency.

BACKGROUND AND OBJECTIVES: Variability in practice patterns and resource use in the emergency department (ED) can affect costs without affecting outcomes. ED quality measures have not included resource use in relation to ED outcomes and efficiency. Our objectives were to develop a tool for comprehensive physician feedback on practice patterns relative to peers and to study its impact on resource use, quality, and efficiency. METHODS: We evaluated condition-specific resource use (laboratory tests; imaging; antibiotics, intravenous fluids, and ondansetron; admission) by physicians at 2 tertiary pediatric EDs for 4 common conditions (fever, head injury, respiratory illness, gastroenteritis). Resources used, ED length of stay (efficiency measure), and 72-hour return to ED (return rate [RR]) (balancing measure) were reported on scorecards with boxplots showing physicians their practice relative to peers. Quarterly scorecards were distributed for baseline (preintervention, July 2009-August 2010) and postintervention (September 2010-December 2011). Preintervention, postintervention, and trend analyses were performed. RESULTS: In 51 450 patient visits (24 834 preintervention, 26 616 postintervention) seen by 96 physicians, we observed reduced postintervention use of abdominal and pelvic and head computed tomography scans, chest radiographs, intravenous antibiotics, and ondansetron (P < .01 for all). Hospital admissions decreased from 7.4% to 6.7% (P = .002), length of stay from 112 to 108 minutes (P < .001), and RR from 2.2% to 2.0%. Trends for use of laboratory tests and intravenous antibiotics showed significant reduction (P < .001 and P < .05, respectively); admission trends increased, and trends for use of computed tomography scans and plain abdominal radiographs showed no change. CONCLUSIONS: Physician feedback on practice patterns relative to peers results in reduction in resource use for several common ED conditions without adversely affecting ED efficiency or quality of care.

Clinical and laboratory characteristics of disseminated herpes simplex virus infection in neonates.

BACKGROUND AND OBJECTIVES: Disseminated herpes simplex virus (HSV) infection is the most fulminant type of neonatal HSV infection and has the highest mortality. Early diagnosis and treatment are essential for patient survival. We describe the clinical presentation, laboratory characteristics, and outcomes of neonates with disseminated HSV infection at our institution. METHODS: A retrospective review of electronic medical records from 2006 to 2013 was performed. Only neonates with disseminated HSV infection, confirmed by using polymerase chain reaction or viral culture results, were included. RESULTS: Twenty-two cases were identified; the age range was 1 to 14 days. The majority of patients did not have a maternal history of HSV or a history of maternal fever at delivery. Eleven of the patients were delivered by cesarean delivery, and 3 of these patients did not have prolonged rupture of membranes. Neonatal fever, the most common historical characteristic, was present in only one-half of the patients. Pneumonia and respiratory distress were present in one-half of the patients. Serum aspartate aminotransferase and alanine aminotransferase levels were elevated in most, but not all, patients. The blood HSV polymerase chain reaction was positive in all patients tested. Of the 22 study patients, 16 survived and 6 died. The majority of the patients who died had respiratory disease and a delay in the initiation of acyclovir therapy. CONCLUSIONS: Disseminated HSV infection in neonates can be challenging to diagnose and is associated with high mortality. Clinicians must strongly consider this diagnosis, test the blood for HSV polymerase chain reaction, and initiate early treatment in the appropriate clinical scenarios.

Low-echo sphere phantoms and methods for assessing imaging performance of medical ultrasound scanners.

Tissue-mimicking phantoms and software for quantifying the ability of human observers to detect small low-echo spheres as a function of depth have been developed. Detectability is related to the imager's ability to delineate the boundary of a 3-D object such as a spiculated tumor. The phantoms accommodate a broad range of transducer shapes and sizes. Three phantoms are described: one with 2-mm-diameter spheres (for higher frequencies), one with 3.2-mm-diameter spheres (for lower frequencies) and one with 4-mm-diameter spheres (for lower frequencies). The spheres are randomly distributed in each phantom. The attenuation coefficients of spheres and surroundings are nearly identical; thus, compromising shadowing or enhancement distal to spheres does not occur. Reproducibility results are given for pairs of independent data sets involving eight different combinations of scanner, transducer and console settings. The following comparison results are also reported: (i) only the selected frequency differs; (ii) transducers and scan parameters are nearly the same but manufacturers differ; (iii) ordinary B-scanning, spatial compounding and tissue harmonic imaging are addressed. The phantoms and software promise to be valuable tools for scanning system and setup comparisons and for acceptance testing.

Community household income and resource utilization for common inpatient pediatric conditions.

BACKGROUND AND OBJECTIVE: Child health is influenced by biomedical and socioeconomic factors. Few studies have explored the relationship between community-level income and inpatient resource utilization for children. Our objective was to analyze inpatient costs for children hospitalized with common conditions in relation to zip code-based median annual household income (HHI). METHODS: Retrospective national cohort from 32 freestanding children's hospitals for asthma, diabetes, bronchiolitis and respiratory syncytial virus, pneumonia, and kidney and urinary tract infections. Standardized cost of care for individual hospitalizations and across hospitalizations for the same patient and condition were modeled by using mixed-effects methods, adjusting for severity of illness, age, gender, and race. Main exposure was median annual HHI. Posthoc tests compared adjusted standardized costs for patients from the lowest and highest income groups. RESULTS: From 116,636 hospitalizations, 4 of 5 conditions had differences at the hospitalization and at the patient level, with lowest-income groups having higher costs. The individual hospitalization level cost differences ranged from $187 (4.1%) to $404 (6.4%). Patient-level cost differences ranged from $310 to $1087 or 6.5% to 15% higher for the lowest-income patients. Higher costs were typically not for laboratory, imaging, or pharmacy costs. In total, patients from lowest income zip codes had $8.4 million more in hospitalization-level costs and $13.6 million more in patient-level costs. CONCLUSIONS: Lower community-level HHI is associated with higher inpatient costs of care for 4 of 5 common pediatric conditions. These findings highlight the need to consider socioeconomic status in health care system design, delivery, and reimbursement calculations.

Evaluation of the impact of backscatter intensity variations on ultrasound attenuation estimation.

PURPOSE: Quantitative ultrasound based approaches such as attenuation slope estimation can be used to determine underlying tissue properties and eventually used as a supplemental diagnostic technique to B-mode imaging. The authors investigate the impact of backscatter intensity and frequency dependence variations on the attenuation slope estimation accuracy. METHODS: The authors compare three frequency domain based attenuation slope estimation algorithms, namely, a spectral difference method, the reference phantom method, and two spectral shift methods: a hybrid method and centroid downshift method. Both the reference phantom and hybrid method use a tissue-mimicking phantom with well-defined acoustic properties to reduce system dependencies and diffraction effects. The normalized power spectral ratio obtained is then filtered by a Gaussian filter centered at the transmit center frequency in the hybrid method. A spectral shift method is then used to estimate the attenuation coefficient from the normalized and filtered spectrum. The centroid downshift method utilizes the shift in power spectrum toward lower frequencies with depth. Numerical phantoms that incorporate variations in the backscatter intensity from -3 to 3 dB, by varying the scatterer number density and variations in the scatterer diameters ranging from 10 to 100 µm are simulated. Experimental tissue mimicking phantoms with three different scatterer diameter ranges (5-40, 75-90, and 125-150 µm) are also used to evaluate the accuracy of the estimation methods. RESULTS: The reference phantom method provided accurate results when the acoustical properties of the reference and the sample are well matched. Underestimation occurs when the reference phantom possessed a higher sound speed than the sample, and overestimation occurs when the reference phantom had a lower sound speed than the sample. The centroid downshift method depends significantly on the bandwidth of the power spectrum, which in turn depends on the frequency dependence of the backscattering. The hybrid method was the least susceptible to changes in the sample's acoustic properties and provided the lowest standard deviation in the numerical simulations and experimental evaluations. CONCLUSIONS: No significant variations in the estimation accuracy of the attenuation coefficient were observed with an increase in the scatterer number density in the simulated numerical phantoms for the three methods. Changes in the scatterer diameters, which result in different frequency dependence of backscatter, do not significantly affect attenuation slope estimation with the reference phantom and hybrid approaches. The centroid method is sensitive to variations in the scatterer diameter due to the frequency shift introduced in the power spectrum.

Children's hospitals with shorter lengths of stay do not have higher readmission rates.

OBJECTIVE: To test the hypothesis that children's hospitals with shorter length of stay (LOS) for hospitalized patients have higher all-cause readmission rates. STUDY DESIGN: Longitudinal, retrospective cohort study of the Pediatric Health Information System of 183616 admissions within 43 US children's hospitals for appendectomy, asthma, gastroenteritis, and seizure between July 2009 and June 2011. Admissions were stratified by medical complexity, based on whether patients had a complex chronic health condition, were neurologically impaired, or were assisted with medical technology. Outcome measures include LOS; all-cause readmission rates within 3, 7, 15, and 30 days; and the association between hospital-specific mean LOS and all-cause readmission rates as determined by linear regression. RESULTS: Mean LOS was <3 days for all patients across all conditions, except for appendectomy in complex patients (mean LOS 3.7 days, 95% CI 3.47-4.01). Condition-specific 3-, 7-, 15-, and 30-day all-cause readmission rates for noncomplex patients were all <5%. Condition-specific readmission rates for complex patients ranged from <1% at 3 days for seizures to 16% at 30 days for gastroenteritis. There was no linear association between hospital-specific, condition-specific mean LOS, stratified by medical complexity, and all-cause readmission rates at any time interval within 30 days (all P values ≥.10). CONCLUSION: In children's hospitals, LOS is short and readmission rates are low for asthma, appendectomy, gastroenteritis, and seizure admissions. In the conditions studied, there is no association between shorter hospital-specific LOS and higher readmission rates within the LOS observed.

Telecardiology on Vancouver Island: imagination to implementation.

In 2011, there were more than 97,000 people living with Heart Failure in British Columbia (BC) with a total of 17,592 within VIHA. To increase patient accessibility to specialist care, the Vancouver Island Health Authority (VIHA) implemented a telecardiology program that utilizes digital stethoscopes, telehealth technology and collaboration to deliver cardiac care remotely. The program has successfully completed 20 consultations to date in 6 communities within the VIHA. This article outlines processes and outcomes of enabling the existing VIHA cardiology program with the use of telehealth technologies.

A nonlinear elasticity phantom containing spherical inclusions.

The strain image contrast of some in vivo breast lesions changes with increasing applied load. This change is attributed to differences in the nonlinear elastic properties of the constituent tissues suggesting some potential to help classify breast diseases by their nonlinear elastic properties. A phantom with inclusions and long-term stability is desired to serve as a test bed for nonlinear elasticity imaging method development, testing, etc. This study reports a phantom designed to investigate nonlinear elastic properties with ultrasound elastographic techniques. The phantom contains four spherical inclusions and was manufactured from a mixture of gelatin, agar and oil. The phantom background and each of the inclusions have distinct Young's modulus and nonlinear mechanical behavior. This phantom was subjected to large deformations (up to 20%) while scanning with ultrasound, and changes in strain image contrast and contrast-to-noise ratio between inclusion and background, as a function of applied deformation, were investigated. The changes in contrast over a large deformation range predicted by the finite element analysis (FEA) were consistent with those experimentally observed. Therefore, the paper reports a procedure for making phantoms with predictable nonlinear behavior, based on independent measurements of the constituent materials, and shows that the resulting strain images (e.g., strain contrast) agree with that predicted with nonlinear FEA.

Physician practice variation in the pediatric emergency department and its impact on resource use and quality of care.

OBJECTIVE: To evaluate variation in case-mix adjusted resource use among pediatric emergency department (ED) physicians and its correlation with ED length of stay (LOS) and return rates. METHODS: Resource use patterns at 2 EDs for 36 academic physicians (163,669 patients at ED1) and 45 private physicians (289,199 patients at ED2) from 2003 to 2006 were abstracted for common laboratory tests, imaging studies, intravenous therapy (fluids/antibiotics), LOS and 72-hour return rate for discharged patients, and hospital admissions for all patients. Case-mix adjustment was based on triage acuity, diagnostic category, demographics, and temporal measures. OUTCOME MEASURES: (1) adjusted overall resource use for ED1 and ED2 physicians and (2) observed-to-expected ratios for ED1 physicians. RESULTS: Case-mix adjusted hospital admission rates among physicians varied nearly 3-fold (6.3%-18%) for ED1 and 8-fold (2.5%-19.4%) for ED2. Intravenous therapy use varied 2-fold (4.9%-10.4%) at ED1 and 3-fold (3.6%-11.4%) at ED2. Emergency department 2 physicians had an almost 2-fold (10.9%-20.6%) variation in imaging use. Variation in head computed tomography use was 2-fold (1.1%-2.5%) at ED1 and 5-fold (0.9%-4.8%) at ED2. Physicians had longer than expected LOS if they had higher than expected use of laboratory tests (r, 0.41; 95% confidence interval [CI], 0.09-0.65; P < 0.05) and imaging (r, 0.48; 95% CI, 0.17-0.69; P < 0.01). Return rate was not significantly correlated with resource use in any category. Physicians with higher than expected use of laboratory tests had higher than expected use of imaging (r, 0.62; 95% CI, 0.36-0.78; P < 0.001), head computed tomography (r, 0.49; 95% CI, 0.19-0.70; P < 0.01), and intravenous therapy (r, 0.51; 95% CI, 0.20-0.71; P < 0.01). CONCLUSIONS: Significant variation exists in physician use of common ED resources. Higher resource use was associated with increased LOS but did not reduce return to ED. Practice variation such as this may represent an opportunity to improve health care quality and decrease costs.

Anechoic sphere phantoms for estimating 3-D resolution of very-high-frequency ultrasound scanners.

Two phantoms have been constructed for assessing performance of high-frequency ultrasound imagers. They also allow for periodic quality assurance tests and training technicians in the use of higher-frequency scanners. The phantoms contain eight blocks of tissue-mimicking material; each block contains a spatially random distribution of suitably small anechoic spheres having a small distribution of diameters. The eight mean sphere diameters are distributed from 0.10 to 1.09 mm. The two phantoms differ primarily in terms of the frequency dependence of the backscatter coefficient of the background material. Because spheres have no preferred orientation, all three (spatial) dimensions of resolution contribute to sphere detection on an equal basis; thus, the resolution is termed 3-D. Two high-frequency scanners are compared. One employs single-element (fixed focus) transducers (25 and 55 MHz), and the other employs variable focus linear arrays (20, 30, and 40 MHz). The depth range for detection of spheres of each size is determined corresponding to determination of 3-D resolution as a function of depth. As expected, the single-element transducers are severely limited in useful imaging depth ranges compared with the linear arrays. In this preliminary report, only one human observer analyzed images.

Nonlinear elastic behavior of phantom materials for elastography.

The development of phantom materials for elasticity imaging is reported in this paper. These materials were specifically designed to provide nonlinear stress/strain relationship that can be controlled independently of the small strain shear modulus of the material. The materials are mixtures of agar and gelatin gels. Oil droplet dispersions in these materials provide further control of the small strain shear modulus and the nonlinear parameter of the material. Since these materials are mostly water, they are assumed to be incompressible under typical experimental conditions in elasticity imaging. The Veronda-Westman model for strain energy density provided a good fit to all materials used in this study. Materials with a constant gelatin concentration (3.0% dry weight) but varying agar concentration (0.6-2.8% dry weight) demonstrated the same power law relationship between elastic modulus and agar concentration found for pure agar (1.89 +/- 0.02), consistent with percolation theory, and provided a consistent nonlinearity parameter of 4.5 +/- 0.3. The insights provided by this study will form the basis for stable elastography phantoms with stiffness and nonlinear stress/strain relationships in the background that differ from those in the target.

Evaluation of a cardiac ultrasound segmentation algorithm using a phantom.

This paper evaluates the performance of a level set algorithm for segmenting the endocardium in short-axis ultrasound images. The evaluation is carried out using an anthropomorphic ultrasound phantom. Details of the phantom design, including comparison of the ultrasound parameters with in-vitro measurements, are included. In addition to measuring segmentation accuracy, the effectiveness of the energy minimization scheme is also determined. It is argued that using the phantom along with global minimization algorithms (simulated annealing and random search) makes is possible to assess the minimization strategy.

Anthropomorphic phantoms for assessment of strain imaging methods involving saline-infused sonohysterography.

Two anthropomorphic uterine phantoms were developed that allow assessment and comparison of strain imaging systems adapted for use with saline-infused sonohysterography (SIS). Tissue-mimicking (TM) materials consist of dispersions of safflower oil in gelatin. TM fibroids are stiffer than the TM myometrium/cervix, and TM polyps are softer. The first uterine phantom has 3-mm-diameter TM fibroids distributed randomly in TM myometrium. The second uterine phantom has a 5-mm and 8-mm spherical TM fibroid, in addition to a 5-mm spherical and a 12.5-mm-long (medicine capsule-shaped) TM endometrial polyp protruding into the endometrial cavity; also, a 10-mm spherical TM fibroid projects from the serosal surface. Strain images using the first phantom show the stiffer 3-mm TM fibroids in the myometrium. Results from the second uterine phantom show that, as expected, parts of inclusions projecting into the uterine cavity will appear very stiff, whether they are stiff or soft. Results from both phantoms show that although there is a five-fold difference in the Young's moduli values, there is not a significant difference in the strain in the transition from the TM myometrium to the TM fat. These phantoms allow for realistic comparison and evolution of SIS strain imaging techniques and can aid clinical personnel to develop skills for SIS strain imaging.