ABSTRACT
We report a 73 years old man with a diagnosis of Paget Disease (PD) and symptomatic Multiple Myeloma (MM). Coexistence of MM and PD has rarely been described. PD mimics many of the features of bone destructive process in MM, making differential diagnosis more complicated. In addition, the presence of serious muscolo-skeletal and metabolic complications in both diseases makes management of patients difficult, worsening the prognosis.The comparison of these two diseases has led to the characterization of a common molecular mechanism represented by the receptor activator of nuclear factor-kB ligand (RANKL)/Osteoprotegerin signaling pathway. The improved comprehension of these mechanisms led to the development of new pharmacologic agents (bisphosphonates, cytokines inhibitors) effective for the treatment of these bone diseases.
ABSTRACT
Herein, we report the case of a 52-year-old man with a spermatic cord liposarcoma that developed 4 years after renal transplantation. The patient was admitted with a diagnosis of inguinal hernia. During surgical exploration, a solid mass was found arising from the spermatic cord. Histologic analysis demonstrated a well-differentiated sclerosing liposarcoma.
Subject(s)
Genital Neoplasms, Male/surgery , Kidney Transplantation/physiology , Liposarcoma/surgery , Polycystic Kidney Diseases/surgery , Spermatic Cord/pathology , Spermatic Cord/surgery , Genital Neoplasms, Male/pathology , Hernia, Inguinal/pathology , Hernia, Inguinal/surgery , Humans , Kidney Transplantation/pathology , Male , Middle Aged , Polycystic Kidney Diseases/pathology , Treatment OutcomeABSTRACT
A rare case of cystic angiomatoid fibrous histiocytoma of the thigh in a 13-years-old girl is reported. Final diagnosis was made only after surgical excision. A review of the literature with a discussion of the particularity of this case are also examined in order to achieve the best surgical strategy and the lower risk of recurrence.
Subject(s)
Cysts/pathology , Histiocytoma, Malignant Fibrous/pathology , Adolescent , Cysts/diagnosis , Diagnosis, Differential , Female , Histiocytoma, Malignant Fibrous/diagnosis , HumansSubject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Boronic Acids/pharmacology , Multiple Myeloma/drug therapy , Plasma Cells/drug effects , Pyrazines/pharmacology , Skin/pathology , Aged , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Boronic Acids/administration & dosage , Boronic Acids/adverse effects , Bortezomib , Dexamethasone/therapeutic use , Female , Humans , Immunoglobulin A/blood , Melphalan/administration & dosage , Multiple Myeloma/pathology , Myeloma Proteins/analysis , Paresthesia/chemically induced , Peripheral Nervous System Diseases/chemically induced , Plasma Cells/pathology , Prednisone/administration & dosage , Pyrazines/administration & dosage , Pyrazines/adverse effects , Remission Induction , Thalidomide/administration & dosage , Thalidomide/adverse effects , Xerophthalmia/chemically inducedABSTRACT
A 41 year old man with a history of politrauma presented with a nodular mass of the left false vocal cord, associated with progressive dysphonia, dyspnoea, and dysphagia. A computed tomography scan of the neck region showed a rounded and circumscribed mass without infiltration of the surrounding tissues. Histological investigation of the nodule revealed the presence of fibroelastic cartilaginous tissue, surrounded by a thin rim of fibrous tissue, with rare hypercellular areas, occasional binucleated cells, slight hyperchromasia, and an irregular nuclear profile. Mitotic activity was absent. The patient's history of laryngeal trauma, with the subsequent progressive onset of clinical symptoms, helps to distinguish the chondrometaplastic nature of this nodule from true laryngeal cartilaginous tumours, such as chondroma and low grade chondrosarcoma.
