1.
Org Lett
; 4(12): 1981-4, 2002 Jun 13.
Article
in English
| MEDLINE
| ID: mdl-12049497
ABSTRACT
[reaction: see text] An efficient method has been developed for the stereocontrolled construction of polycyclic and spirocyclic compounds, including the spirocyclic core of the antitumor agent fredericamycin A. The strategy involves a one-pot aldol addition/Brook rearrangement/cyclization sequence beginning from arene chromium tricarbonyl complexes and can formally be described as a [3 + 2] annulation.