ABSTRACT
Two recent cases of massive bleeding from a solitary rectal ulcer which occurred in patients at The Mount Sinai Hospital are presented. This unusual complication of a poorly understood condition has been treated in the past by a variety of medical and surgical approaches; no consensus has been reached. In both cases an abdominal rectosigmoid resection was ultimately performed after local control and diversion were unsuccessful. A review of the literature and a discussion of this new approach are presented.
Subject(s)
Gastrointestinal Hemorrhage/etiology , Rectal Diseases/complications , Aged , Female , Gastrointestinal Hemorrhage/surgery , Humans , Rectal Diseases/surgery , Recurrence , Ulcer/complications , Ulcer/surgeryABSTRACT
Malignant fibrous histiocytoma (MFH) of the gastrointestinal tract is extremely rare. A case of MFH of the colon associated with neurofibromatosis is presented. MFH is a high-grade soft-tissue sarcoma of fibroblast cell origin with a strong propensity for metastasis and recurrence. Immunochemical markers help to differentiate MFH from other sarcomas. The most successful treatment of MFH is surgical extirpation. Adjuvant chemotherapy and radiotherapy have not been definitively shown to be of value.
Subject(s)
Colonic Neoplasms/complications , Histiocytoma, Benign Fibrous/complications , Neurofibromatosis 1/complications , Colonic Neoplasms/surgery , Female , Histiocytoma, Benign Fibrous/surgery , Humans , Middle Aged , Neurofibromatosis 1/surgeryABSTRACT
The absorption of ranitidine from different segments of the intestinal tract was studied in a subject who had an anatomically divided small intestine. The results indicate that the drug is maximally absorbed from the small bowel rather than the stomach. Subsequent animal studies have shown that absorption of ranitidine in dogs is primarily duodenal followed by jejunal and ileal. The lack of gastric absorption, with predominantly small bowel absorption, may have investigational and therapeutic implications in a variety of gastrointestinal diseases.
Subject(s)
Gastric Mucosa/metabolism , Intestine, Small/metabolism , Ranitidine/pharmacokinetics , Animals , Dogs , Humans , Intestinal Absorption , Male , Middle AgedSubject(s)
Colon/blood supply , Gastrointestinal Hemorrhage/etiology , Varicose Veins/complications , Humans , Male , Middle AgedSubject(s)
Appendix , Diverticulum/diagnosis , Appendix/surgery , Cecal Diseases/diagnosis , Cecal Diseases/surgery , Diverticulum/surgery , Female , Humans , Middle AgedSubject(s)
Abscess/complications , Diverticulitis/complications , Intestinal Perforation/complications , Sigmoid Diseases/complications , Abscess/diagnostic imaging , Diverticulitis/diagnostic imaging , Female , Humans , Intestinal Perforation/diagnostic imaging , Middle Aged , Radiography , Retroperitoneal Space/diagnostic imaging , Sigmoid Diseases/diagnostic imagingABSTRACT
Difficulty in resection of the uncinate process of the pancreas often results in significant hemorrhage. Partial vascular occlusion of the superior mesenteric vein with resection of the lateral wall allows complete removal of all pancreatic tissue with minimal blood loss.
Subject(s)
Pancreas/surgery , Pancreatectomy/methods , HumansABSTRACT
Although sarcoidosis has been described affecting almost all body systems, acute cholecystitis has not previously been documented. Such a case is presented with a review of other gastrointestinal tract manifestations of the disease.
