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1.
J Reprod Med ; 35(3): 214-8, 1990 Mar.
Article in English | MEDLINE | ID: mdl-2325029

ABSTRACT

To compare the efficacy of antibiotic prophylaxis through uterine lavage in women undergoing cesarean section in labor to the efficacy of the more standard, perioperative intravenous method, we prospectively randomized 100 women to receive either 2 g of cefotaxime in 1,000 mL of normal saline with a lavage protocol or 1 g of cefotaxime intravenously after cord clamping followed by 1-g doses 6 and 12 hours later. The two groups were similar with respect to age, gestational age, race, weight, length of labor and of ruptured membranes, use of internal monitoring, blood loss and number of vaginal examinations. Standard febrile morbidity and postpartum endomyometritis requiring antibiotic therapy occurred in 18% and 12%, respectively, of the lavage group and in 16% and 12%, respectively, of the intravenous group. Before the routine use of prophylactic antibiotics for cesarean section in labor on our service, the febrile morbidity and endomyometritis rates were 36% and 32%, respectively. The results confirm the benefit of prophylactic antibiotics for cesarean section in labor and demonstrate that the lavage and intravenous methods are similar with respect to efficacy.


Subject(s)
Cefotaxime/administration & dosage , Cesarean Section , Endometritis/prevention & control , Premedication , Adult , Cefotaxime/therapeutic use , Female , Humans , Injections, Intravenous , Labor, Obstetric , Pregnancy , Therapeutic Irrigation , Uterus
2.
South Med J ; 82(4): 443-5, 1989 Apr.
Article in English | MEDLINE | ID: mdl-2705070

ABSTRACT

Many factors contribute to the attainment of adult height, including genetic and environmental variables. To assess the relationship between menarcheal age and adult height, measured adult height and recalled menarcheal age were compared by regression analysis in 425 women. The overall regression equation, Height = 158.14 + .4321 (Age) - .1667 (Age - 13)2, was significant (P less than .003), as was the coefficient for the quadratic term (P not equal to .014). After exclusion of those in whom menarche occurred after age 16, the overall linear regression equation for the remaining 416 patients, Height = 153.95 + .7353 (Age), was still significant (P not equal to .001), but the coefficient for the quadratic term was not. These data suggest that menarcheal age significantly correlates with adult height as an independent variable.


Subject(s)
Body Height , Menarche/physiology , Adult , Age Factors , Biometry , Female , Humans , Middle Aged , Regression Analysis
3.
Fertil Steril ; 51(4): 582-6, 1989 Apr.
Article in English | MEDLINE | ID: mdl-2924928

ABSTRACT

Five regularly menstruating women of proven fertility, with normal prolactin and thyroid function studies, underwent a total of 39 endometrial biopsies (EMBs). The slides were dated in blinded fashion, and the cycle date determined by considering the date of the next menstrual period as day 28 and counting backward. Using a 2-day or greater lag in endometrial maturity to define a luteal phase defect (LPD), the incidence of single and sequential out-of-phase EMBs was 51.4% and 26.7%, respectively. Using a 3-day or greater lag to define a LPD, the incidence of single and sequential out-of-phase EMBs was 31.4% and 6.6%, respectively. These incidences in normal, fertile women are as high as the rates quoted for infertile populations, and call into question the standard criteria for defining this condition and evaluating therapies to correct it.


Subject(s)
Endometrium/pathology , Luteal Phase , Adult , Biopsy , Female , Humans , Infertility, Female/pathology , Pregnancy
4.
Am J Surg ; 155(5A): 81-5, 1988 May 31.
Article in English | MEDLINE | ID: mdl-3287974

ABSTRACT

In a multicenter, randomized clinical trial, 282 women who underwent abdominal or vaginal hysterectomy were given a single preoperative 2 g dose of cefotetan (171 evaluable patients) or three perioperative 2 g doses of cefoxitin (84 evaluable patients) as antibiotic prophylaxis. A successful clinical response occurred in 92 percent of those receiving cefotetan and 90 percent of those receiving cefoxitin who underwent abdominal hysterectomy, and in 94 percent of those receiving cefotetan and 93 percent of those receiving cefoxitin who underwent vaginal hysterectomy. The incidence of vaginal cuff cellulitis was 3.4 percent and 5 percent for cefotetan and cefoxitin patients, respectively, who underwent abdominal hysterectomy, and 4.8 percent and 4.5 percent, respectively, for those who underwent vaginal hysterectomy. The incidence of major wound infection was 3.4 percent and 2.5 percent for cefotetan and cefoxitin, respectively, in the abdominal hysterectomy group. Postoperative changes in oral body temperature, duration of hospitalization, and postoperative grading of surgical wounds were similar. Both drugs were well tolerated. These results suggest that a single dose of cefotetan is equally effective and as safe as multiple-dose cefoxitin for prophylaxis in patients undergoing hysterectomy.


Subject(s)
Cefoxitin/therapeutic use , Cephamycins/therapeutic use , Hysterectomy , Premedication , Surgical Wound Infection/prevention & control , Adult , Cefotetan , Cefoxitin/administration & dosage , Cefoxitin/toxicity , Cephamycins/administration & dosage , Cephamycins/toxicity , Clinical Trials as Topic , Female , Humans , Random Allocation
5.
Am J Obstet Gynecol ; 158(3 Pt 2): 706-9, 1988 Mar.
Article in English | MEDLINE | ID: mdl-3128112

ABSTRACT

The safety and efficacy of parenteral prophylaxis with either cefotetan or cefoxitin were evaluated in a prospective, randomized study of 355 subjects undergoing abdominal or vaginal hysterectomy. Each subject received either a single 1 gm dose of cefotetan intravenously 30 to 60 minutes before operation or three 2 gm doses of cefoxitin, the first 30 to 60 minutes before operation and subsequent doses 6 and 12 hours later. Prophylaxis was successful in 69 of 70 (98.6%) receiving cefotetan and 32 of 33 (97.0%) receiving cefoxitin who underwent vaginal hysterectomy. Prophylaxis was successful in 160 of 169 (94.7%) receiving cefotetan and in 79 of 83 (95.2%) receiving cefoxitin who underwent abdominal hysterectomy. Both drugs were well tolerated and without serious side effects or complications. On the basis of these findings, we conclude that a single 1 gm dose of cefotetan given before operation is as safe and effective as a multiple-dosing regimen of cefoxitin in subjects undergoing vaginal hysterectomy and in those undergoing abdominal hysterectomy at institutions where prophylaxis is indicated.


Subject(s)
Cefoxitin/therapeutic use , Cephamycins/therapeutic use , Hysterectomy, Vaginal , Hysterectomy , Infection Control , Postoperative Complications/prevention & control , Abdomen , Adult , Cefotetan , Cefoxitin/administration & dosage , Cephamycins/administration & dosage , Female , Genital Diseases, Female/prevention & control , Humans , Middle Aged , Prospective Studies , Random Allocation , Surgical Wound Infection/prevention & control
6.
Surg Gynecol Obstet ; 162(3): 204-8, 1986 Mar.
Article in English | MEDLINE | ID: mdl-3513346

ABSTRACT

Thirty-four patients with pelvic inflammatory disease, postoperative, postabortal and postpartum infections were randomized to intravenous therapy with either 500 milligrams of imipenem and cilastatin sodium every six hours or 2 grams of moxalactam every eight hours for a minimum of four days. One patient in the moxalactam group was nonevaluable because of protocol noncompliance; three more patients had no bacteriologic pathogen isolated (two in the moxalactam group and one patient in the imipenem/cilastatin group). The two groups were similar with respect to age, diagnosis, etiologic agents and duration of therapy. Of the 17 evaluable patients in the imipenem/cilastatin group, all were complete clinical cures. Three patients in the imipenem/cilastatin group had persistence of at least one bacteriologic pathogen despite clinical cure and apparent laboratory evidence of susceptibility. Of the 13 evaluable patients in the moxalactam group, eight were complete clinical cures. Two more patients in that group were clinically improved enough to be discharged on oral antibiotics. There were three clinical failures in the moxalactam group, all of whom had group D streptococcus resistant to moxalactam. An additional three patients in the moxalactam group had other resistant organisms isolated despite clinical cure. Both drugs were well tolerated and no serious complications or side effects occurred in either group. Despite small numbers, our data suggest that imipenem and cilastatin is a more appropriate agent for initial treatment of obstetric and gynecologic infections than moxalactam.


Subject(s)
Cyclopropanes/therapeutic use , Dipeptidases/antagonists & inhibitors , Endometritis/drug therapy , Moxalactam/therapeutic use , Pelvic Inflammatory Disease/drug therapy , Pregnancy Complications, Infectious/drug therapy , Thienamycins/therapeutic use , Acute Disease , Adolescent , Adult , Cesarean Section/adverse effects , Cilastatin , Clinical Trials as Topic , Cyclopropanes/administration & dosage , Drug Administration Schedule , Drug Therapy, Combination , Female , Humans , Imipenem , Moxalactam/administration & dosage , Pregnancy , Random Allocation , Thienamycins/administration & dosage
7.
Surg Gynecol Obstet ; 161(5): 457-61, 1985 Nov.
Article in English | MEDLINE | ID: mdl-3901359

ABSTRACT

Moxalactam was compared with cefazolin and a control group to determine the efficacy and value of a third generation cephalosporin in abdominal hysterectomy antibiotic prophylaxis. One hundred patients were prospectively randomized in a double-blind manner between moxalactam and cefazolin. An additional 50 patients who were either allergic to penicillin or refused participation in this study were simultaneously observed to establish a base line level of infection on our service during this time period. Dosage for both antibiotic groups was 1 gram given intravenously or intramuscularly on call to the operating room followed by two 1 gram doses at six and 12 hours after the first dose. Standard febrile morbidity was 36, 30 and 42 per cent for moxalactam, cefazolin and control groups, respectively. Postoperative surgical infection requiring antibiotic treatment occurred in 8, 6 and 4 per cent, respectively; urinary tract infection or symptomatic findings, or both, requiring treatment occurred in 8, 10 and 10 per cent, respectively. No pelvic abscesses occurred in this series. In every statistical evaluation of postoperative morbidity, there were no differences noted among the three groups. Our results suggest no benefit from the use of prophylactic antibiotics in abdominal hysterectomy in terms of standard febrile or infectious morbidity or urinary tract pathologic findings. In addition, there was no difference between the two antibiotic groups.


Subject(s)
Cefazolin/administration & dosage , Hysterectomy , Moxalactam/administration & dosage , Adolescent , Adult , Clinical Trials as Topic , Drug Evaluation , Female , Humans , Middle Aged , Postoperative Complications/prevention & control , Preoperative Care , Surgical Wound Infection/prevention & control
8.
Obstet Gynecol ; 66(1): 31-5, 1985 Jul.
Article in English | MEDLINE | ID: mdl-4011068

ABSTRACT

To determine the incidence of vaginal mucosal alterations associated with the use of digitally inserted tampons, 100 women were prospectively evaluated colposcopically for three consecutive menstrual cycles. Three groups of 20 women each used the regular, super, and super-plus sizes of a digitally inserted rayon and cotton tampon; two additional groups of 20 each used external sanitary protection or an applicator-inserted rayon polyacrylate tampon. Vaginal mucosal drying and layering were significantly more common in all tampon users than in pad users; vaginal mucosal ulceration was a more rare event, seen only in tampon users, and statistically more commonly in the rayon polyacrylate group. The incidence of these alterations was not related to the presence of Staphylococcus aureus. All ulcerations healed without treatment. The common occurrence and relatively benign nature of these changes are discussed in view of the concern that these changes might predispose a woman to developing toxic shock syndrome.


Subject(s)
Menstrual Hygiene Products/adverse effects , Ulcer/pathology , Vaginal Diseases/pathology , Adolescent , Adult , Antibodies, Bacterial/analysis , Female , Humans , Middle Aged , Mucous Membrane/pathology , Prospective Studies , Random Allocation , Shock, Septic/etiology , Staphylococcus aureus/immunology , Ulcer/etiology , Ulcer/microbiology , Vagina/pathology , Vaginal Diseases/etiology , Vaginal Diseases/microbiology
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