ABSTRACT
BACKGROUND: Study of hypertension in segments of West African populations in transition toward Westernization may lead to better understanding of the high risk for hypertension among Westernized blacks. METHODS: Five hundred fifty-nine urban civil servants, ages 25-54, were recruited from six ministries of Bendel State, Nigeria. Blood pressure, physical measurements, urinary protein and glucose, fasting blood glucose, and demographic data were collected at the workplace. Subjects were classified as senior staff (professionals or administrators) or junior staff (non-administrators). RESULTS: Among 172 male senior staff, the age-adjusted rate of hypertension (diastolic blood pressure > or = 90 mm Hg, systolic blood pressure > or = 140 mm Hg, or on an antihypertensive medication) was 43% and occurrence rose dramatically from 21 to 63% across age groups 25-34 to 45-54, respectively. Among 266 male junior staff, the age-adjusted rate of hypertension was 23%, and occurrence did not rise with age. Logistic regression showed that body mass index (kg/m2), age, alcohol drinking, and being senior staff were all independently related to hypertension in men. On the other hand, the age-adjusted rate of hypertension in 121 women was 20% and was significantly related only to body mass index. CONCLUSION: Male urban civil servants appeared to have a risk for hypertension similar to that of U.S. black males. Age, body mass index, alcohol drinking, and other unidentified factors related to higher socioeconomic status were strong determinants of hypertension in this population.
Subject(s)
Hypertension/epidemiology , Occupational Diseases/epidemiology , Adult , Alcohol Drinking/adverse effects , Alcohol Drinking/epidemiology , Antihypertensive Agents/therapeutic use , Body Mass Index , Educational Status , Female , Government , Humans , Hypertension/drug therapy , Hypertension/etiology , Incidence , Logistic Models , Male , Middle Aged , Nigeria/epidemiology , Occupational Diseases/drug therapy , Occupational Diseases/etiology , Occupations , Risk Factors , Urban PopulationABSTRACT
A neural network simulator was used for the recognition of the presence and location of the peak of wave V of the brain stem auditory evoked potential (BAEP) test. Waveforms selected from BAEPs performed in the last 4 years at the University of Pittsburgh Presbyterian University Hospital were digitized and sampled, and the resulting amplitudes were normalized. A training set was composed of the waveforms resulting from the stimulation of 50 ears. The normalized amplitudes were used as the initial activation values for the networks. The desired outputs (the target locations for wave V) were represented in the output layer by setting the output element, which corresponded to the target location and its immediate neighbors, to high activation levels, and all the remaining output units to zero activity. Two network architectures, differing only in the hidden unit layer, with 40 and 16 hidden units, respectively, were trained by using standard back-propagation. Several trials from different starting points were performed for each architecture. The best network, found after 60 epochs (3,000 presentations), was able to correctly identify 17 of 20 cases (85%) from a set of test cases that were independent from the training set.
Subject(s)
Evoked Potentials, Auditory, Brain Stem/physiology , Neural Networks, Computer , Evaluation Studies as Topic , Expert Systems , Humans , Reproducibility of Results , Sensitivity and SpecificityABSTRACT
A neural network simulator was used to create a connectionist model for the recognition of the peak of wave V of the brain stem auditory evoked potential (BAEP) test. Wave forms were selected from BAEPs performed in the last four years at the University of Pittsburgh Presbyterian University Hospital (PUH). The ipsilateral and contralateral wave forms were digitized and then sampled at 0.1 msec intervals using linear interpolation. The resulting amplitudes were normalized to the range less than -1, 1 greater than. The normalized amplitudes were used as the initial activation values for the processing elements of the input layer. The desired outputs (the target locations for wave V) were determined by adjusting the latencies recorded by the physician interpreter for any distortion in the digitizing process. The location of wave V was represented in the output layer by setting the output element which correspond to the target location and its immediate neighbors to high activation levels and all the remaining output units to zero activity. Two network architectures, differing only in the hidden unit layer, with 40 and 16 hidden units respectively, were used. The networks were trained using standard back-propagation. Several trials from different starting points were performed for each architecture. The training set was composed of the wave forms resulting from the stimulation of 50 ears. The best network, found after 60 epochs (3000 presentations) was able to correctly identify 17 out of 20 cases (85%) from a set of test cases which were independent from the training set.
Subject(s)
Diagnosis, Computer-Assisted/methods , Evoked Potentials, Auditory, Brain Stem , Neural Networks, Computer , Signal Processing, Computer-Assisted , HumansABSTRACT
This cross-sectional study of urban, Nigerian civil servants found that age, body mass index, alcohol drinking and high socioeconomic status were all positively and independently related to blood pressure among 438 males. Among 121 females, only body mass index was significantly related to blood pressure.
Subject(s)
Black or African American , Blood Pressure , Urban Population , Adult , Age Factors , Alcohol Drinking , Black People , Body Weight , Female , Humans , Male , Middle Aged , Nigeria , Regression Analysis , Social ClassABSTRACT
In this study, we examined the relationship of two common genetic markers in black populations, sickle cell trait and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, to cardiovascular risk factors. The subjects were Nigerian civil servants in Benin City, Nigeria. We measured blood pressure, height, weight, sickle cell hemoglobin, G-6-PD, proteinuria, microalbuminuria and fasting serum cholesterol, high-density lipoprotein cholesterol (HDL), triglycerides, apoprotein (APO) AI, and APO B. Data were collected on age, alcohol consumption, cigarette smoking, job status, and years lived in an urban area. There were 257 males (3 SS hemoglobin, 73 AS, 181 AA) and 69 females (23 AS, 46 AA). In comparing cardiovascular risk factors, males differed only in percent of smokers (31.5 in AS vs. 17.8 in AA, P less than 0.01). Among females, only high-density lipoprotein (HDL) cholesterol differed (61.5 mg/dl in AS vs. 52.4 in AA, P less than 0.01). We hypothesize that females with sickle cell trait are more likely to use oral contraceptives than nontrait females. If so, the high-estrogen oral contraceptives available in Nigeria could elevate HDL. G-6-PD deficiency status among males (52 deficient, 207 nondeficient) and females (1 deficient, 5 carriers, 65 nondeficient) was not related to any of the cardiovascular risk factors. We conclude that sickle cell hemoglobin trait and G-6-PD deficiency are not useful genetic markers for risk factors for cardiovascular disease.
