Subject(s)
Cardiovascular Diseases/epidemiology , Estrogen Replacement Therapy/adverse effects , Estrogens, Conjugated (USP)/adverse effects , Medroxyprogesterone Acetate/adverse effects , Postmenopause/drug effects , Randomized Controlled Trials as Topic/standards , Data Interpretation, Statistical , Female , Humans , Risk Factors , Time FactorsABSTRACT
OBJECTIVE: To evaluate if the levels of the central regulators of osteoclast activity, osteoprotegerin (OPG) and receptor activator for nuclear factor kappaB-ligand (RANk-L), correlate with bone mineral density (BMD) parameters in premenopausal infertile women. DESIGN: Cross-sectional study. SETTING: Academic infertility practice. PATIENT(S): 82 Infertile, but otherwise healthy, premenopausal women< 42 years age presenting for routine care. INTERVENTION(S): BMD assessment; serum samples (cycle days 1 to 3), questionnaire addressing demographics, medical, social, family, and personal histories. MAIN OUTCOME MEASURE(S): BMD categorized as "Low" (Z