Prevalencia de la depresión en pacientes con artritis reumatoide o espondilitis anquilosante / Prevalence of depression in patients with rheumatoid arthritis or ankylosing spondylitis

Objetivo: Estudiar la frecuencia de depresión en pacientes con artritis reumatoide y espondilitis anquilopoyética.Pacientes y métodos: Estudio transversal. Se estudiaron 164 pacientes con artritis reumatoide, 44 con espondilitis anquilopoyética y 143 controles vistos consecutivamente durante un año. Todos rellenaron los ítems del cuestionario Zung-Conde para el diagnóstico de la depresión, considerándose con depresión aquéllos cuya puntuación era mayor o igual a 48, normales si era menor o igual a 32 y como estado intermedio entre 33 y 47. Las medias de las puntuaciones en los tres grupos se compararon entre sí mediante el test de la t de Student.Resultados: En las artritis reumatoide, espondilitis anquilopoyética y grupo control, los resultados fueron, respectivamente: 19 por ciento, 32 por ciento y 59 por ciento normales; 43 por ciento, 50 por ciento, 35 por ciento en un estadio intermedio; 38 por ciento, 32 por ciento y 6 por ciento depresivos. La media de puntuación fue para la artritis reumatoide, espondilitis anquilopoyética y controles de 44ñ12,9 (rango 20-75); 39ñ9,6 (rango 20-59) y 31ñ9,5 (rango 20-61 ), respectivamente, con una p<0,001 para la artritis reumatoide y espondilitis anquilopoyética frente al grupo control.Conclusiones: Los pacientes con artritis reumatoide y espondilitis anquilopoyética padecen depresión con mayor frecuencia que la población general (AU)

Bilateral ossifying fibroma of the maxillary sinus.

A case involving a 35-year-old man with massive, bilateral, slow-growing ossifying fibromas in the maxillary sinuses resulting in facial deformity and orbital compression is discussed. The historical difficulty in categorizing fibro-osseous lesions and the importance of clinical, radiographic, and surgical findings relating to the proper diagnosis and treatment are reviewed. The use of the CT scan to delineate the extent of the pathologic lesion is demonstrated.

Alterations in glycoconjugate expression following malignant transformation of human oropharyngeal squamous mucosa.

Malignant transformation of the squamous mucosa in the human oropharynx may be accompanied by alterations in carbohydrate production. Glycoconjugate expression was assessed by examining lectin-binding patterns and ABH isoantigen expression in human biopsy specimens from nine cases of carcinoma in situ and ten cases of invasive squamous cell carcinoma as well as adjacent normal squamous mucosa. Ten different fluorescein-conjugated lectins were used. Each lectin binds to specific nonreducing end-terminal carbohydrate residues. Wheat germ agglutinin and peanut agglutinin displayed intense cytoplasmic and/or membrane binding in more than 90% of the carcinoma in situ and squamous cell carcinoma specimens. However, only 40% of normal squamous epithelium specimens displayed intense cytoplasmic and/or membrane binding with wheat germ agglutinin and peanut agglutinin. Bandieraea simplicifolia I and Helix pomatia exhibited weak binding in less than 35% of normal and neoplastic tissues. Weak canavalia ensiformis binding was identified infrequently in the superficial layers of normal squamous mucosa, but was not found in neoplastic epithelium. None of the cases displayed binding for Dolichos biflorus, Ulex europaeus I, Sophora japonica, Glycine maximus, or Ricinus communis. Monoclonal antibodies directed against ABH blood group isoantigens showed increased cytoplasmic immunoreactivity for anti-H in dysplastic and neoplastic tissues, when compared with normal squamous mucosa. These findings indicate that wheat germ agglutinin and peanut agglutinin and H isoantigen are useful markers of malignancy in squamoproliferative lesions of the oropharynx, apparently reflecting alterations in expression of N-acetyl-D-glucosamine and galactose-related sugars, which appear following malignant transformation.

Spontaneous tooth exfoliation and osteonecrosis following a herpes zoster infection of the fifth cranial nerve.

Spontaneous exfoliation of teeth and osteonecrosis of the alveolar bone are rare complications of HZ infection that usually follow the acute phase of infection. Awareness of osteonecrosis associated with secondary HZ infection is important for early detection and treatment of the condition to prevent further complications, particularly in high-risk patients.