Yeast carboxymethyl-glucan improves endothelial function and inhibits platelet aggregation in spontaneously hypertensive rats.

Carboxymethyl-glucan is a semi-synthetic derivative of ß-D-glucan, a polysaccharide widely found in several natural sources, such as yeast, fungi, and cereals. This compound has beneficial effects on health and is considered an important immunomodulator. However, studies exploring carboxymethyl-glucan bioactivity in cardiovascular health remain lacking, mainly in hypertension. Thus, this study sought to expand understanding of the effects of carboxymethyl-glucan on vascular and platelet functions in a hypertensive animal model. Spontaneously hypertensive rats and their normotensive Wistar-Kyoto controls were assigned to five groups: control, carboxymethyl-glucan (60 mg kg-1), control spontaneously hypertensive rats, spontaneously hypertensive rats carboxymethyl-glucan (20 mg kg-1), and spontaneously hypertensive rats carboxymethyl-glucan (60 mg kg-1). Animals were treated for four weeks with carboxymethyl-glucan at doses of 20 and 60 mg kg-1 orally, and control rats received saline as a placebo. Vascular reactivity, platelet aggregation, and reactive oxygen species production were evaluated at the end of treatment. The results showed that carboxymethyl-glucan improved vascular function and reduced platelet aggregation, mainly at a 60 mg kg-1 dose. However, despite these effects, there was no reduction in levels of reactive oxygen species. These findings suggested that carboxymethyl-glucan modulates endothelial function. It also acts as a platelet antiaggregant, which is an interesting resource for managing hypertension and its thrombotic complications.

Carboxymethyl-glucan from Saccharomyces cerevisiae reduces blood pressure and improves baroreflex sensitivity in spontaneously hypertensive rats.

Carboxymethyl-glucan (CMG) is a derivative of ß-D-glucan extracted from Sacharomyces cerevisae. This polymer presents improved physicochemical properties and shows health benefits, such as immunomodulation, antioxidant, anti-inflammatory, anti-tumor, and antiplatelet activities, and improved vascular function. However, studies concerning the effect of administration of CMG on the cardiovascular parameters, mainly in the field of hypertension, are scarce. This study aimed to investigate the effect of administration of CMG in spontaneously hypertensive rats (SHR) and normotensive rats (WKY) models. Normotensive and hypertensive animals received CMG at doses of 20 mg kg-1 and 60 mg kg-1 for four weeks. Then, weight gain, lipid profile, renal function, blood pressure, cardiac hypertrophy, baroreflex sensitivity, and sympathetic tone were evaluated. Oral administration of CMG influenced weight gain and cholesterol levels, and significantly reduced urea in the hypertensive animals. It decreased blood pressure levels and cardiac hypertrophy, improved baroreflex response, and reduced the influence of sympathetic tone. The results demonstrate the antihypertensive effect of CMG through improvement in baroreflex sensitivity via sympathetic tone modulation.