ABSTRACT
OBJECTIVES: To explore male human papillomavirus (HPV) contemporary genotyping epidemiology and correlations to peniscopy, cytology, and histopatology. METHODS: Medical records of patients who had been submitted to HPV infection screening with genotyping, peniscopy, cytology, and histopathology in a period of 2 years were reviewed. Frequency analysis and correlations between the diagnostic tools were established. RESULTS: Genotype of 1132 men resulted in 69.2% (784) positivity for HPV DNA, 78% classified as high risk of oncogenesis. Co-infections occurred in 429 (54.7%) and the most frequently identified types were HPV-6, HPV-42, and HPV-16, in 133 (17%), 94 (12%), and 86 (11%) patients, respectively. Positive/negative predictive values of peniscopy, cytology, and histopathology were 83/31%, 92/32%, and 87/33%, respectively. As a result, though significant, the correlations between genotype and non-molecular tests were poor. CONCLUSIONS: In the current contemporary representative male cohort, over two thirds are positive for human HPV DNA, 78% of high risk and with over half co-infections. Though significant, its correlation with non-molecular tests is poor and while the positive predictive values of peniscopy, cytology, and histopatology are between 83% and 92%, their negative predictive values are as low as 31% to 33%.
Subject(s)
Alphapapillomavirus/isolation & purification , Human papillomavirus 16/genetics , Human papillomavirus 6/genetics , Papillomavirus Infections/diagnosis , Papillomavirus Infections/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Alphapapillomavirus/classification , Alphapapillomavirus/genetics , Carcinoma in Situ/virology , Child , Condylomata Acuminata/virology , Cytodiagnosis , DNA, Viral/genetics , Genotype , Human papillomavirus 16/isolation & purification , Human papillomavirus 6/isolation & purification , Humans , Male , Mass Screening , Middle Aged , Papillomavirus Infections/pathology , Penile Neoplasms/virology , Penis/virology , Sexual Behavior , Young AdultABSTRACT
BACKGROUND: Musculoskeletal disorders account for up to one in four of general-practice consultations and almost one third of complaints in primary-care clinical practice. However, an insufficient amount of time and importance is given to their teaching in most medical schools. OBJECTIVE: To evaluate the acquisition of musculoskeletal competences in our institution, in order to identify flaws and propose changes to correct and improve the musculoskeletal curriculum. DESIGN AND SETTING: Cross-sectional study conducted in São Paulo, Brazil. METHODS: First to fifth-year medical students were enrolled in a survey using the Freedman and Bernstein musculoskeletal examination, in order to evaluate the acquisition of musculoskeletal competencies. Categorical data were analyzed using the chi-square test. Continuous data were analyzed using one-way analysis of variance (ANOVA). The level of significance was set as P < 0.05. RESULTS: A total of 545 students completed the questionnaire: from year 2, 115/167 (29.6%); from year 3, 118/138 (30.4%); from year 4, 98/130 (25.3%); and from year 5, 57/110 (14.7%). None of the students achieved the pass mark (established as 70%). The level of confidence in performing musculoskeletal examination was very low (3.7 ± 2.2; n = 386) and bore no relationship to the percentage of correct answers in the questionnaire (r = 0.331; 95% confidence interval, CI: 0.239-0.417; P < 0.001). CONCLUSION: Undergraduate teaching is the only exposure most general practitioners have to orthopedic problems. Universities are concerned about the adequacy of the musculoskeletal programs taught in their institutions. Student scores were found to be unsatisfactory in all the topics evaluated.
Subject(s)
Education, Medical, Undergraduate , Students, Medical , Brazil , Clinical Competence , Cross-Sectional Studies , Curriculum , Humans , Surveys and QuestionnairesABSTRACT
ABSTRACT BACKGROUND: Musculoskeletal disorders account for up to one in four of general-practice consultations and almost one third of complaints in primary-care clinical practice. However, an insufficient amount of time and importance is given to their teaching in most medical schools. OBJECTIVE: To evaluate the acquisition of musculoskeletal competences in our institution, in order to identify flaws and propose changes to correct and improve the musculoskeletal curriculum. DESIGN AND SETTING: Cross-sectional study conducted in São Paulo, Brazil. METHODS: First to fifth-year medical students were enrolled in a survey using the Freedman and Bernstein musculoskeletal examination, in order to evaluate the acquisition of musculoskeletal competencies. Categorical data were analyzed using the chi-square test. Continuous data were analyzed using one-way analysis of variance (ANOVA). The level of significance was set as P < 0.05. RESULTS: A total of 545 students completed the questionnaire: from year 2, 115/167 (29.6%); from year 3, 118/138 (30.4%); from year 4, 98/130 (25.3%); and from year 5, 57/110 (14.7%). None of the students achieved the pass mark (established as 70%). The level of confidence in performing musculoskeletal examination was very low (3.7 ± 2.2; n = 386) and bore no relationship to the percentage of correct answers in the questionnaire (r = 0.331; 95% confidence interval, CI: 0.239-0.417; P < 0.001). CONCLUSION: Undergraduate teaching is the only exposure most general practitioners have to orthopedic problems. Universities are concerned about the adequacy of the musculoskeletal programs taught in their institutions. Student scores were found to be unsatisfactory in all the topics evaluated.
Subject(s)
Humans , Students, Medical , Education, Medical, Undergraduate , Brazil , Cross-Sectional Studies , Surveys and Questionnaires , Clinical Competence , CurriculumABSTRACT
A coronariopatia e uma doenca altamente prevalente em todo o mundo, tendo assim grande importancia para a comunidade medica. O tratamento considerado mais eficaz tem sido a revascularizacao do miocardio, que pode ser feita tanto por cirurgia do tipo ponte quanto por angioplastia. No entanto, devido ao grau significativo de reestenose deste ultimo procedimento, a tecnica padrao principalmente para revascularizacao de varias coronarias ainda e a cirurgia do tipo ponte (tanto venosa quanto arterial). Ultimamente grandes esforcos tem sido realizados no sentido de tornar a cirurgia o menos traumatica possivel atraves de tecnicas minimamente invasivas. A revascularizacao do miocardio minimamente invasiva tem por objetivo oferecer os mesmos beneficios da cirurgia convencional, apresentando porem, uma menor morbidade, uma vez que evita a circulacao extra-corporea, a esternotomia mediana classica e a manipulacao aortica (fatores que estao associados a maiores complicacoes no pos-operatorio)...
