Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 7 de 7
Filter
1.
Brain Inj ; 32(4): 459-463, 2018.
Article in English | MEDLINE | ID: mdl-29355397

ABSTRACT

INTRODUCTION: The aim of this study was to validate the S100B protein as a diagnostic tool for ruling out the presence of intracranial lesion (IL) after mild traumatic brain injury (mTBI). Subjects with a Glasgow Coma Scale (GCS) score of 15 and at least one neurological symptom post-trauma were selected from a large Spanish cohort. METHODS: A number of 260 patients with mTBI were enrolled. Blood samples were extracted within 6 h and CT scan performed within 24 h post-injury. Blood samples were also drawn from 18 healthy subjects. RESULTS: CT scan revealed the presence of IL in 22 patients (8.5%). Patients with mTBI had higher S100B serum levels (p = 0.008) than the healthy subjects (p < 0.001). The ROC analysis of S100B discriminated between patients with and without IL (AUC: 0.671; 95%CI: 0.574-0.769; p = 0.008). The multivariate analysis identified male gender (OR: 5.39; 95%CI: 1.45-20.10; p = 0.012), age > 65 (OR: 2.97; 95%CI: 1.04-8.44; p = 0.041) and S100B level >0.10 µg/L (OR: 7.93; 95%CI: 1.03-60.76; p = 0.046) as independent risk factors for IL in patients with mTBI. CONCLUSION: Measurement of S100B within 6 h of mTBI accurately predicts risk of IL in patients with a GCS score of 15 and at least one neurological symptom.


Subject(s)
Brain Injuries, Traumatic/blood , S100 Calcium Binding Protein beta Subunit/blood , Adult , Aged , Brain Injuries, Traumatic/diagnostic imaging , Cohort Studies , Female , Glasgow Coma Scale , Humans , Logistic Models , Male , Middle Aged , Multivariate Analysis , Spain , Tomography Scanners, X-Ray Computed , Young Adult
2.
J Head Trauma Rehabil ; 33(1): 46-52, 2018.
Article in English | MEDLINE | ID: mdl-28195955

ABSTRACT

BACKGROUND: The aim of this work was to validate the IMPACT (International Mission for Prognosis and Analysis of Clinical Trials in TBI) model in a Spanish cohort of patients with moderate-severe TBI (traumatic brain injury). SETTING: Two level I neurotrauma centers. PARTICIPANTS: Patients admitted to these hospitals between 2011 and 2014 with a diagnosis of TBI and a Glasgow Coma Scale score of 12 or less. DESIGN: Prospective observational study. MAIN MEASURES: We collected prospectively the clinical variables included in the IMPACT models. Outcome evaluation was prospectively done at 6-month follow-up according to the Glasgow Outcome Scale. RESULTS: A total of 290 patients were included in the study. Forty-seven patients (16.2%) died within 6 months post-TBI, and 74 patients (25.5%) had an unfavorable outcome. The Hosmer-Lemeshow test revealed that there was no difference between observed and predicted outcomes; hence, the 3 models displayed adequate calibration for predicting 6-month mortality or unfavorable outcome. The receiver operating characteristic curve indicated that the 3 models (Core, Extended, and Lab) could accurately discriminate between favorable and unfavorable outcomes, as well as between survival and mortality (P < .001). CONCLUSION: The IMPACT model validates prediction of 6-month outcomes in a Spanish population of moderate-severe TBI. IMPACT Lab model is the one that presents a higher discriminative capacity. These results encourage the implementation of the IMPACT model as a prognostic tool in the management of patients with TBI.


Subject(s)
Brain Injuries, Traumatic/diagnosis , Brain Injuries, Traumatic/mortality , Adult , Cohort Studies , Female , Glasgow Coma Scale , Glasgow Outcome Scale , Humans , Male , Middle Aged , Models, Statistical , Outcome Assessment, Health Care , Predictive Value of Tests , Prognosis , ROC Curve , Spain , Survival Rate
5.
Med. clín (Ed. impr.) ; 149(3): 122-127, ago. 2017.
Article in Spanish | IBECS | ID: ibc-164960

ABSTRACT

Durante años ha existido preocupación por la identificación de pacientes con traumatismo craneoencefálico (TCE) leve en alto riesgo de presentar lesión intracraneal (LI) subsidiaria de intervención neuroquirúrgica. El pequeño porcentaje de pacientes de estas características, y la mortalidad excepcional ligada al TCE leve con LI, han llevado a reconsiderar la elevada utilización de recursos como la tomografía craneal (TC). Los diversos protocolos desarrollados para el manejo del TCE leve se basan en la identificación de factores de riesgo de presentar LI, lo que finalmente permite indicar o descartar selectivamente tanto la solicitud de TC como la estancia hospitalaria para la vigilancia neurológica. Finalmente, el avance realizado en el estudio de biomarcadores de lesión cerebral con utilidad de carácter pronóstico, en diferentes categorías clínicas del TCE, ha sido recientemente incorporado por diversas guías de práctica clínica, lo que ha permitido, junto con la valoración clínica, una estimación pronóstica más exacta para estos pacientes (AU)


There has been concern for many years regarding the identification of patients with mild traumatic brain injury (TBI) at high risk of developing an intracranial lesion (IL) that would require neurosurgical intervention. The small percentage of patients with these characteristics and the exceptional mortality associated with mild TBI with IL have led to the high use of resources such as computerised tomography (CT) being reconsidered. The various protocols developed for the management of mild TBI are based on the identification of risk factors for IL, which ultimately allows more selective indication or discarding both the CT application and the hospital stay for neurological monitoring. Finally, progress in the study of brain injury biomarkers with prognostic utility in different clinical categories of TBI has recently been incorporated by several clinical practice guidelines, which has allowed, together with clinical assessment, a more accurate prognostic approach for these patients to be established (AU)


Subject(s)
Humans , Craniocerebral Trauma/epidemiology , Brain Injury, Chronic/epidemiology , Biomarkers/analysis , Prognosis , Practice Patterns, Physicians' , Tomography, X-Ray Computed , Glasgow Outcome Scale , Platelet Aggregation Inhibitors/administration & dosage , Anticoagulants/administration & dosage , Neurologic Examination
6.
Med Clin (Barc) ; 149(3): 122-127, 2017 Aug 10.
Article in English, Spanish | MEDLINE | ID: mdl-28571951

ABSTRACT

There has been concern for many years regarding the identification of patients with mild traumatic brain injury (TBI) at high risk of developing an intracranial lesion (IL) that would require neurosurgical intervention. The small percentage of patients with these characteristics and the exceptional mortality associated with mild TBI with IL have led to the high use of resources such as computerised tomography (CT) being reconsidered. The various protocols developed for the management of mild TBI are based on the identification of risk factors for IL, which ultimately allows more selective indication or discarding both the CT application and the hospital stay for neurological monitoring. Finally, progress in the study of brain injury biomarkers with prognostic utility in different clinical categories of TBI has recently been incorporated by several clinical practice guidelines, which has allowed, together with clinical assessment, a more accurate prognostic approach for these patients to be established.


Subject(s)
Brain Concussion/diagnosis , Biomarkers/metabolism , Brain Concussion/physiopathology , Brain Concussion/therapy , Humans , Neuroimaging , Neurosurgical Procedures , Prognosis , Risk Assessment , Tomography, X-Ray Computed , Trauma Severity Indices
SELECTION OF CITATIONS
SEARCH DETAIL
...