High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats.

Although High Intensity Interval Training (HIIT) are being associated to increase cardiovascular and metabolic adaptation, there is controversy and limited information about the effects of HIIT on hippocampal oxidative stress, pro- and anti-inflammatory cytokines balance and neurotrophic status. Thus, this study evaluated the effects of six weeks of HIIT on hippocampal redox state (oxidative damage and enzymatic and non-enzymatic antioxidant defenses), neuroimmune mediators (TNFα, IL-6, IL-1ß and IL-10) and brain-derived neurotrophic (BDNF) levels. After six weeks of HIIT young adults male Wistar rats presented reduced oxidative damage and increased enzymatic (superoxide dismutase) and non-enzymatic activity in hippocampus. Moreover HIIT induced a decrease in cytokine content (TNFα, IL-6, IL-1ß and IL-10) and enhanced hippocampal BDNF levels. In conclusion, the present study showed for the first time a positive effect of six weeks of HIIT on reducing hippocampal oxidative stress by decreasing lipoperoxidation and inflammatory markers, as well enhancing antioxidant defenses and BDNF content.

Dependência química pelo crack: vivências e percepções dos discentes do internato de um curso médico / Chemical dependence on crack: experiences and perceptions of internship students of a medical school

Modelo de estudo: Estudo transversal e qualitativo. Objetivos: Este trabalho investiga as vivências e identifica as percepções dos discentes do internato do nono período de medicina de uma universidade pública, sobre dependência química pelo crack. Metodologia: Estudo transversal de abordagem qualitativa, cujo instrumento da pesquisa foi uma entrevista individual, utilizando-se um roteiro semiestruturado, que permite amplo discurso dos discentes. As falas das gravações foram transcritas e depois realizada a análise do conteúdo segundo Bardin. Resultados: Foram identificadas categorias referentes ao sentimento da vivência, à percepção do discente sobre a dependência do crack e seu aprendizado sobre o tema, aos comprometimentos físicos, aos outros prejuízos causados e a como a sociedade deve lidar diante da dependência química pelo crack. Os sentimentos de compaixão e de preservação estão presentes em suas vivências. Os discentes relacionam as questões econômicas, profissionais e familiares como fontes das graves consequências do crack. Valorizam os prejuízos sociais e existenciais, a autodestruição, a violência e o emagrecimento que o crack causa aos usuários, além da codependência. É grande a preocupação dos discentes com a prevenção, educação, informação, eliminação do preconceito e cobranças de ações governamentais para combate ao crack. Conclusão: Os discentes do internato consideram a dependência química pelo crack como problema social e doença.Definem como insuficiente o aprendizado sobre a dependência química pelo crack durante o curso. Suas vivências e percepções geram impactos positivos, pois apontam para futuros egressos melhor preparados, que deverão acolher o dependente e sua família de forma mais ampla, humana e eficaz.

Study design: Cross-sectional and qualitative study. Objectives: This study investigates experiences and identifies the perceptions of ninth-term intern medical students of a public university on the crack addiction issue. Methods: A qualitative-approach and cross-sectional study which had as the research tool a semi-structured, individual interview allowing broad speech of students. Recording reports were transcribed and content analysis carried out according to Bardin. Results: categories were identified concerning the feeling of experience, the students’ perception on crack addiction and their learning on the subject, physical impairments and additional damages, besides how society should deal with the addiction on crack. The feelings of compassion and preservation are present in their experiences. Students point out economic, professional and family issues as the sources of serious crack addiction consequences. They also take into account the social and existential damages, the self-destruction, violence and weight loss caused on crack users, as well as the codependency. There is a great concernon the part of students related to prevention, education, information, elimination of prejudice, as well as demands of government efforts to combat crack. Conclusion: The intern medical students consider crack addiction both a social problem and a disease; define learning about addiction by crack insufficient throughout the course. Their experiences and perceptions generate positive impacts since they prospect better prepared graduates who shall receive the one addicted and his family in a broader, more effective and humane way.

Mandible and Zygomatic Fracture in a 2-Year-Old Patient due to Dog Bite.

Dog bite injury frequently occurs in children, and many of these bites involve the facial region. On the other hand, facial fractures due to dog attacks are a rare complication, with the orbital, nasal, and maxillary bones most often affected. We present a case report of a child who suffered a double facial fracture, mandible and left zygoma, due to a dog bite. The clinical diagnosis was supported by X-rays and computed tomography, which also provided information about the characteristics of the fracture. Internal fixation was done with titanium miniplates. Finally, the pathophysiological mechanism and the biomechanics of the fracture, as well as the use of resorbable versus nonresorbable material on infants, are discussed.