ABSTRACT
BACKGROUND: Initially described by Gorlin et al. in 1962, the calcifying cystic odontogenic tumor (CCOT) may be associated with unerupted teeth, ameloblastomas, adenomatoid odontogenic tumors, and, in many cases, with odontomas. It is rare in patients in the first decade of life, particularly involving deciduous teeth. Surgery is the treatment of choice, with low recurrence rates. CASE REPORT: We present a clinical case of CCOT associated with odontoma and a missing deciduous tooth in a 3-year-old female patient. The lesion was removed under general anesthesia. The patient has been followed up for 1 year, and no recurrence was found. This appears to be the first report in such a young age.
Subject(s)
Neoplasms, Multiple Primary/diagnosis , Odontogenic Cyst, Calcifying/diagnosis , Odontoma/diagnosis , Tooth, Deciduous , Child, Preschool , Diagnosis, Differential , Female , Humans , Neoplasms, Multiple Primary/pathology , Neoplasms, Multiple Primary/surgery , Odontogenic Cyst, Calcifying/pathology , Odontogenic Cyst, Calcifying/surgery , Odontoma/pathology , Odontoma/surgeryABSTRACT
Canalicular adenoma is an uncommon benign tumour that generally arises in the minor salivary glands of individuals over 60 years old. This study illustrates a case of canalicular adenoma in a 70-year-old female, presenting as two distinct asymptomatic nodules in the upper lip. Immunohistochemistry analysis was performed. Clinical features, management, histology and immunoprofile from this case and from the literature are discussed.
Subject(s)
Adenoma/diagnosis , Asymptomatic Diseases , Lip Neoplasms/diagnosis , Salivary Gland Neoplasms/diagnosis , Salivary Glands, Minor/pathology , Adenoma/pathology , Aged , Female , Humans , Immunohistochemistry , Immunophenotyping , Keratins/analysis , Ki-67 Antigen/analysis , Lip Neoplasms/pathology , S100 Proteins/analysis , Salivary Gland Neoplasms/pathology , Transcription Factors/analysis , Tumor Suppressor Proteins/analysisABSTRACT
Pleomorphic adenoma (PA), the most common salivary gland tumor, accounts for 54 to 65% of all salivary gland neoplasias and 80% of the benign salivary gland tumors. It most frequently affects the parotid gland, followed by the submandibular and the minor salivary glands. Microscopically, mucous, sebaceous, oncocytic and squamous metaplasia, sometimes with the formation of keratin pearls, may be present, but the latter rarely results in the formation of extensive keratin-filled cysts lined by squamous epithelium. Extensive squamous metaplasia can be mistaken for malignancy, including mucoepidermoid carcinoma and squamous cell carcinoma. Here, we present an unusual case of PA with extensive squamous metaplasia and keratin cyst formations in a minor salivary gland, and discuss its microscopic features, including the immunohistochemical characteristics, and differential diagnosis of this uncommon presentation.
Subject(s)
Adenoma, Pleomorphic/pathology , Salivary Gland Neoplasms/pathology , Salivary Glands, Minor/pathology , Adult , Humans , Immunohistochemistry , Keratins/biosynthesis , Male , MetaplasiaABSTRACT
Pleomorphic adenoma (PA), the most common salivary gland tumor, accounts for 54 to 65 percent of all salivary gland neoplasias and 80 percent of the benign salivary gland tumors. It most frequently affects the parotid gland, followed by the submandibular and the minor salivary glands. Microscopically, mucous, sebaceous, oncocytic and squamous metaplasia, sometimes with the formation of keratin pearls, may be present, but the latter rarely results in the formation of extensive keratin-flled cysts lined by squamous epithelium. Extensive squamous metaplasia can be mistaken for malignancy, including mucoepidermoid carcinoma and squamous cell carcinoma. Here, we present an unusual case of PA with extensive squamous metaplasia and keratin cyst formations in a minor salivary gland, and discuss its microscopic features, including the immunohistochemical characteristics, and differential diagnosis of this uncommon presentation.
Subject(s)
Adult , Humans , Male , Adenoma, Pleomorphic/pathology , Salivary Gland Neoplasms/pathology , Salivary Glands, Minor/pathology , Immunohistochemistry , Keratins/biosynthesis , MetaplasiaABSTRACT
An 11-year-old girl presented to our department to have a second opinion regarding a lesion involving her left mandible. She had previously undergone several radiographic exams including panoramic, helical, and cone-beam computed tomography. Radiographic examinations revealed a well-defined radiolucent region, which contained an irregular radiopaque mass of 3 cm in diameter, localized to the left angle of the mandible. Our presumptive diagnosis was complex odontoma. Excisional biopsy was performed, and microscopic features showed strands and islands of odontogenic epithelium showing peripheral palisading and loosely arranged central cells, identical to stellate reticulum, embedded in a myxoid cell-rich stroma resembling the dental papilla. Dentin and enamel were also presented. The diagnosis was ameloblastic fibro-odontoma, which is a rare mixed odontogenic tumor, derived from epithelial and ectomesenchymal elements that form the dental tissues.
